One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Product Details of 254-60-4, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 254-60-4, Name is 1,8-Diazanaphthalene, molecular formula is C8H6N2
Objective: The search for new, potentially useful antimycobacterial agents. In continuation with our previous screening for the discovery of novel drugs for tuberculosis, a new series of 1,8-naphthyridines derivatives were synthesized and evaluated in vitro for antimycobacterial activity against Mycobacterium tuberculosis H37Rv. Methods: Several 4-morpholinomethyl-1.8-naphthyridine derivatives have been synthesized in excellent yields. The synthesized compounds were characterized by spectroscopic methods as well as elemental analyses. They were screened for their antimycobacterial activity. The growth was monitored radiometrically in 7H12 broth with the BACTEC 460 TB system. The minimum inhibitory concentration (MIC) was determined for compounds that demonstrated ? 90% growth inhibition in the primary screening. Results: The obtained data suggested that all compounds showed significant activity against Mycobacterium tuberculosis H37Rv compared to the standard reference drug. Analogues (6-11) having heterocyclic groups in position 7 were the most potent of those we tested. Conclusion: These findings clearly identify the 1,8-naphthyridine analogue (10) with a 6-amino-2-(4′-methoxy benzylamine-4-morpholinomethyl- 7-morpholino-substituent as promising anti-tubercular agents possessing significant activity against Mycobacterium tuberculosis H37Rv.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Product Details of 254-60-4, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 254-60-4, in my other articles.
Reference£º
1,51-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N45 – PubChem