Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Recommanded Product: 16415-12-616415-12-6, Name is Hexadecyltrimethoxysilane, SMILES is CO[Si](OC)(CCCCCCCCCCCCCCCC)OC, belongs to naphthyridines compound. In a article, author is Stockmann, Vegar, introduce new discover of the category.
Synthesis of Novel 1,7-Naphthyridines by Friedlander Condensation of Pyridine Substrates
The general ability of appropriate pyridyl compounds (aldehyde or ketone) to undergo Friedlander condensation to give different 1,7-naphthyridines has been demonstrated. 2,4-Disubstituted 1,7-naphthyridine 8 was prepared from 3-amino-4-acetylpyridine (6) and ketone 4 (82%). The Friedlander self-condensation of pyridyl substrate 6 is reported, as well. The dimer product, 2-(3-aminopyridin-4-yl)-4-methyl- 1,7-naphthyridine (7), was obtained in 97% yield. 2-Aryl-and 2,3-diaryl-1,7-naphthyridines (1618) were prepared from 3-aminoisonicotinaldehyde (13) and arylketones 4, 14, and 15 (28-71%). The key substrates 6 and 13 are readily available via the improved pyridine nitration method.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 16415-12-6. Recommanded Product: 16415-12-6.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem