The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. SDS of cas: 5959-52-4, 5959-52-4, Name is 3-Amino-2-naphthoic acid, SMILES is NC1=CC2=C(C=CC=C2)C=C1C(O)=O, in an article , author is Kaila, Neelu, once mentioned of 5959-52-4.
Identification of a novel class of selective Tpl2 kinase inhibitors: 4-alkylamino-[1,7]naphthyridine-3-carbonitriles
We have previously reported the discovery and initial SAR of the [1,7]naphthyridine-3-carbonitriles and quinoline-3-carbonitriles as Tumor Progression Loci-2 (Tp12) kinase inhibitors. In this paper, we report new SAR efforts which have led to the identification of 4-alkylamino-[1,7]naphthyridine-3-carbonitriles. These compounds show good in vitro and in vivo activity against Tp12 and improved pharmacokinetic properties. In addition they are highly selective for Tp12 kinase over other kinases, for example, EGFR, MEK, MK2, and p38. Lead compound 4-cycloheptylamino-6-[(pyridin-3-ylmethyl)-amino]-[1,7]naphthyridine-3-carbonit-rile (30) was efficacious in a rat model of LPS-induced TNF-alpha production. (C) 2007 Elsevier Ltd. All rights reserved.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 5959-52-4, you can contact me at any time and look forward to more communication. SDS of cas: 5959-52-4.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem