The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 6165-69-1, Name is 3-Thiopheneboronic acid, SMILES is OB(C1=CSC=C1)O, in an article , author is Bunce, Richard A., once mentioned of 6165-69-1, Quality Control of 3-Thiopheneboronic acid.
Ethyl 1,4-Dihydro-4-oxo-1,8-naphthyridine-3-carboxylates by a Tandem SNAr-Addition-Elimination Reaction
A series of N-substituted 1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate esters has been prepared in two steps from ethyl 2-(2-chloronicotinoyl)acetate. Treatment of the beta-ketoester with N,N-dimethylformamide dimethyl acetal in N,N-dimethylformamide (DMF) gave a 95% yield of the 2-dimethylaminomethylene derivative. Subsequent reaction of this beta-enaminone with primary amines in DMF at 120oC for 24 h then afforded the target compounds in 4782% yields by a tandem SNAr-addition-elimination reaction. Synthetic and procedural details as well as a mechanistic rationale are presented.
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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem