Chemistry, like all the natural sciences, Safety of 3-Chlorophenylboronic acid, begins with the direct observation of nature— in this case, of matter.63503-60-6, Name is 3-Chlorophenylboronic acid, SMILES is ClC1=CC=CC(=C1)B(O)O, belongs to naphthyridine compound. In a document, author is Grzegozek, M, introduce the new discover.
Methylamination of some 3-nitro-1,5-naphthyridines with liquid methylamine/potassium permanganate
3-Nitro-1,5-naphthyridine and its 2-substituted derivatives (1a-f) are dehydro-methy laminated with a solution of potassium permanganate in liquid methylamine (LMA-PP) to the corresponding 4-methylamino-3-nitro-1,5-naphthyridines (3a-e). The intermediary 4-methylamino sigma adducts of 2-R-3-nitro-1,5-naphthyridines (R = H, NH2, Cl, NHCH3, OC2H5, OH) (2a-f) are detected by H-1 nmr spectroscopy. The observed highly regioselective course of study reactions was confirmed by PM3 quantum chemical calculations of the reaction pathway. The calculations show satisfactory agreement between calculated and observed results. A convenient synthesis of 2-hydroxy- and 4-methylamino-3-nitro-1,5-naphthyridine are reported.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 63503-60-6. Safety of 3-Chlorophenylboronic acid.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem