New Advances in Chemical Research in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 2835-95-2, Name is 5-Amino-2-methylphenol, molecular formula is , belongs to naphthyridine compound. In a document, author is Narender, A., Quality Control of 5-Amino-2-methylphenol.
2-Cyclopropyl-[1,8]naphthyridine-3-carboxylic acid ethyl ester 1 reacts with 99% hydrazine hydrate, to yield 2-cyclopropyl-[1,8]naphthyridine-3-carboxylic acid hydrazide 2, which further reacts with carbon disulphide in the presence of potassium hydroxide solution to yield compound 3. Compound 3 reacts with 99% hydrazine hydrate to offer 4-amino-5-(2-cyclopropyl-[1,8]naphthyridin-3-yl)-4H-[1,2,4]triazole-3-thiol 4. Compound 4 is converted to 5 by reaction with phenacyl bromides. On other hand compound 4 on treatment with oxalyl chloride in the presence of triethyl amine provides 6. Compound 3 on treatment with acetic acid in water gives compound 7. On the other hand compound 3 on treatment with phenacyl bromides provides compound 8. Compound 1 reacts with guanidine hydrochloride to yield compound 9 which reacts with aromatic nitriles to offer compound 10.
These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 2835-95-2, Quality Control of 5-Amino-2-methylphenol.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem