Category: naphthyridine. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-Iodo-2-furaldehyde, is researched, Molecular C5H3IO2, CAS is 2689-65-8, about New hydrazide-hydrazones of isonicotinic acid: synthesis, lipophilicity and in vitro antimicrobial screening. Author is Popiolek, Lukasz; Biernasiuk, Anna; Berecka, Anna; Gumieniczek, Anna; Malm, Anna; Wujec, Monika.
This study describes the synthesis, lipophilicity and in vitro antimicrobial assays of 15 new hydrazide-hydrazones of isonicotinic acid. New derivatives were obtained on the basis of the condensation reaction of isonicotinic acid hydrazide with different aromatic aldehydes. The chem. structure of synthesized compounds was confirmed by spectral methods. Exptl. lipophilicity of new isonicotinic acid derivatives was determined using reversed-phase thin-layer chromatog. All synthesized compounds were subjected to in vitro antimicrobial assays against reference strains of Gram-pos. bacteria, Gram-neg. bacteria and fungi belonging to Candida spp. Some of the synthesized hydrazide-hydrazones proved to be significant antibacterial compounds and more potent than commonly used chemotherapeutic agents.
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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem