Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 2689-65-8, is researched, SMILESS is IC1=CC=C(O1)C=O, Molecular C5H3IO2Journal, Article, Chemistry & Biodiversity called Synthesis and in vitro antimicrobial activity screening of new 3-acetyl-2,5-disubstituted-1,3,4-oxadiazoline derivatives, Author is Popiolek, Lukasz; Biernasiuk, Anna; Paruch, Kinga; Malm, Anna; Wujec, Monika, the main research direction is synthesis antimicrobial screening acetyloxadiazoline derivative; 1,3,4-oxadiazoline derivatives; antimicrobial activity; biological activity; synthesis design.Synthetic Route of C5H3IO2.
Thirteen new 3-acetyl-2,5-disubstituted-1,3,4-oxadiazoline derivatives were synthesized from corresponding hydrazide-hydrazones of isonicotinic acid in the reaction with acetic anhydride. The obtained compounds were identified with the use of spectral methods (IR, 1H-NMR, 13C-NMR, MS). In vitro antimicrobial activity screening of synthesized compounds against a panel of bacteria and fungi revealed interesting antibacterial and antifungal activity of tested 1,3,4-oxadiazoline derivatives, which is comparable to that of commonly used antimicrobial agents.
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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem