Gurak, John A.; Engle, Keary M. published the article 《Practical Intermolecular Hydroarylation of Diverse Alkenes via Reductive Heck Coupling》. Keywords: alkene aryl iodide reductive Heck hydroarylation palladium; alkylarene regioselective preparation; palladium reductive Heck hydroarylation catalyst; Heck reaction; alkenes; hydroarylation; palladium; regioselectivity.They researched the compound: 5-Iodo-2-furaldehyde( cas:2689-65-8 ).SDS of cas: 2689-65-8. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2689-65-8) here.
The hydroarylation of alkenes is an attractive approach to construct carbon-carbon (C-C) bonds from abundant and structurally diverse starting materials. A palladium-catalyzed reductive Heck hydroarylation of aliphatic and heteroatom-substituted terminal alkenes and select internal alkenes with an array of (hetero)aryl iodides, is reported. The reaction is anti-Markovnikov selective with terminal alkenes and tolerates a wide variety of functional groups on both the alkene and (hetero)aryl coupling partners. Addnl., applications of this method to complex mol. diversifications are demonstrated. Mechanistic experiments are consistent with a mechanism in which the key alkylpalladium(II) intermediate is intercepted with formate and undergoes a decarboxylation/C-H reductive elimination cascade to afford the saturated product and turn over the cycle.
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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem