Zhu, Lingling; Huang, Shanshan; Li, Junhe; Chen, Jun; Yao, Yangyang; Li, Li; Guo, Hui; Xiang, Xiaojun; Deng, Jun; Xiong, Jianping published the artcile< Sophoridine inhibits lung cancer cell growth and enhances cisplatin sensitivity through activation of the p53 and Hippo signaling pathways>, Related Products of 6882-68-4, the main research area is lung cancer sophoridine cisplatin sensitizer p53 Hippo signaling pathways; Cisplatin sensitivity; Hippo; Lung cancer; Sophoridine; p53.
Sophoridine, a quinolizidine alkaloid extracted from the Chinese herb Sophora alopecuroides L., has been reported to exert antitumor effects against multiple human cancers. However, few studies have evaluated its tumor-suppressing effects and associated mechanism with respect to lung cancer, in addition to its potential to be used for clin. lung cancer treatment. Different types of lung cancer cells were used to investigate the antitumor effects of sophoridine using cell viability, colony formation, and cell invasion, and migration assays. To determine the signaling pathways involved, western blot anal., quant. real-time polymerase chain reaction, an in vivo ubiquitination assay, and immunohistochem. were used in cellular assays and with a s.c. xenograft model in BALB/c mice. Sophoridine significantly suppressed the proliferation of and colony formation by lung cancer cells in vitro. Transwell assays demonstrated that sophoridine also inhibited invasion and migration in lung cancer cells. In addition, sophoridine enhanced the effects of cisplatin on lung cancer cells. A mechanistic study revealed that sophoridine significantly activated the Hippo and p53 signaling pathways, and mouse xenograft experiments further confirmed in vitro findings in lung cancer cells. Taken together, these results suggest that sophoridine can inhibit lung cancer progression and enhance the effects of the anticancer drug cisplatin against lung cancer cells. The mechanism of action of sophoridine might involve the Hippo and p53 signaling pathways.
Gene published new progress about Antitumor agents. 6882-68-4 belongs to class naphthyridine, and the molecular formula is C15H24N2O, Related Products of 6882-68-4.
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem