Quiros-Fernandez, Isaac; Figueroa-Protti, Lucia; Arias-Arias, Jorge L.; Brenes-Cordero, Norman; Siles, Francisco; Mora, Javier; Mora-Rodriguez, Rodrigo Antonio published the artcile< Perturbation-Based Modeling Unveils the Autophagic Modulation of Chemosensitivity and Immunogenicity in Breast Cancer Cells>, Application In Synthesis of 1223001-51-1, the main research area is perturbation modeling unveil autophagic modulation chemosensitivity immunogenicity breast cancer; autophagy; chemotherapy; immunogenic cell death; perturbation-based modeling.
In the absence of new therapeutic strategies, chemotherapeutic drugs are the most widely used strategy against metastatic breast cancer, in spite of eliciting multiple adverse effects and having low responses with an average 5-yr patient survival rate. Among the new therapeutic targets that are currently in clin. trials, here, we addressed the association between the regulation of the metabolic process of autophagy and the exposure of damage-associated mol. patterns associated (DAMPs) to immunogenic cell death (ICD), which has not been previously studied. After validating an mCHR-GFP tandem LC3 sensor capacity to report dynamic changes of the autophagic metabolic flux in response to external stimuli and demonstrating that both basal autophagy levels and response to diverse autophagy regulators fluctuate among different cell lines, we explored the interaction between autophagy modulators and chemotherapeutic agents in regards of cytotoxicity and ICD using three different breast cancer cell lines. Since these interactions are very complex and variable throughout different cell lines, we designed a perturbation-based model in which we propose specific modes of action of chemotherapeutic agents on the autophagic flux and the corresponding strategies of modulation to enhance the response to chemotherapy. Our results point towards a promising therapeutic potential of the metabolic regulation of autophagy to overcome chemotherapy resistance by eliciting ICD.
Metabolites published new progress about Autophagosome. 1223001-51-1 belongs to class naphthyridine, and the molecular formula is C24H15F3N4O, Application In Synthesis of 1223001-51-1.
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem