Zhang, Wan-Ying; Chen, Ying; Zhang, Miao-Miao; Zhang, Guo-Wei published the artcile< Molecular mechanism prediction analysis of compound Kushen injection in the treatment of COVID-19 based on network pharmacology and molecular docking>, Application In Synthesis of 6882-68-4, the main research area is COVID 19 compound Kushen injection.
As 1 of the 8 effective traditional Chinese medicines for the treatment of atypical pneumonia, compound Kushen injection (CKI) played an important role in combating pneumonia caused by severe acute respiratory syndrome coronavirus 2 virus in China in 2003. CKI is known to inhibit inflammation, and its main chem. components, namely matrine and oxymatrine, can promote Th cells to recognize and eliminate viruses. In this study, network pharmacol. and mol. docking were used to explore the mechanisms of CKI for treating coronavirus disease 2019. The Traditional Chinese Medicine Systems Pharmacol. Database and Anal. Platform and other related literature were used to screen CKI’s active ingredients in the blood. Traditional Chinese Medicine Systems Pharmacol. Database and Anal. Platform, Swiss Target Prediction and STITCH were used to search for potential targets of the active ingredients. The ingredient-target network was constructed using the Cytoscape software. The STRING online database was used to construct a target protein-protein interaction network that can be visualized and analyzed using the Cytoscape software to obtain key targets. Sophocarpine, sophoridine, matrine, (+)-allomatrine, AIDS211310, and sophranol were the 6 active ingredients. After docking the active ingredients with severe acute respiratory syndrome coronavirus 2 3CL hydrolase and angiotensin-converting enzyme 2 (ACE2), they displayed suitable affinity, which could block viral replication and its binding to ACE2. The key targets mainly involved inflammatory factors, such as interleukin-6 (IL-6) and tumor necrosis factor (TNF). Gene Ontol. enrichment anal. mainly indicated the IL-6 cytokine-mediated signaling pathway and cytokine-mediated signaling pathway. The Kyoto Encyclopedia of Genes and Genome pathway enrichment anal. mainly indicated steroid hormone biosynthesis and the TNF signaling pathway. The alkaloids in CKI can block viral replication and its binding to severe acute respiratory syndrome coronavirus 2 and ACE2 receptors. They regulate the IL-6-mediated signaling pathway, TNF signaling pathway, and steroid hormone biosynthesis, thereby initiating therapeutic responses against COVID-19.
Traditional Medicine Research published new progress about COVID-19. 6882-68-4 belongs to class naphthyridine, and the molecular formula is C15H24N2O, Application In Synthesis of 6882-68-4.
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem