Sakamoto, Takao published the artcileCondensed heteroaromatic ring systems. III. Synthesis of naphthyridine derivatives by cyclization of ethynylpyridinecarboxamides, Product Details of C8H6N2O, the main research area is cyclization ethynylpyridinecarboxamide; naphthyridinone; coupling palladium halopyridine acetylene.
Naphthyridinones I and II (R = H, R1R2, R2R1 = CONHCH:CH; R=Me, R1R2, R2R1 = CONHCPh:CH) were synthesized by the ring closure of pyridinecarboxamides I and II [R = H, R1(R2) = CONH2, R2(R1) = CH2CH(OMe)2; R = Me, R1(R2) = CONH2, R2(R1) = CCPh]. The starting pyridines I [R = H, R1(R2) = cyano, R2(R1)=CCSiMe3; R =Me, R2(R1) = CCPh] and II [R = H, R1(R2) = cyano, R2(R1) = CCSiMe3; R= Me, R1 = CONH2, R2 = CCPh; R = Me, R1 = CCPh, R2 = CO2Et] were easily synthesized by the Pd-catalyzed cross-coupling of halopyridines with PhCCH or Me3SiCCH.
Chemical & Pharmaceutical Bulletin published new progress about Cross-coupling reaction. 67988-50-5 belongs to class naphthyridine, name is 2,7-Naphthyridin-1(2H)-one, and the molecular formula is C8H6N2O, Product Details of C8H6N2O.
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem