Xu, Chang published the artcileDifluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel, Synthetic Route of 53731-26-3, the publication is Nature Communications (2018), 9(1), 1-10, database is CAplus and MEDLINE.
Relatively low reactivity hinders using chlorodifluoromethane (ClCF2H) for general difluoromethylation with organic mols., despite its availability as an inexpensive industrial chem. To date, transformations of ClCF2H are very limited and most of them involve difluorocarbene intermediate. Here, a strategy for difluoromethylation of aromatics through nickel-catalyzed cross-coupling of ClCF2H with readily accessible (hetero)aryl chlorides is described. The reaction proceeds under mild reaction conditions with high efficiency and features synthetic simplicity without preformation of arylmetals and broad substrate scope, including a variety of heteroaromatics and com. available pharmaceuticals. The reliable practicability and scalability of the current nickel-catalyzed process has also been demonstrated by several 10-g scale reactions without loss of reaction efficiency. Preliminary mechanistic studies reveal that the reaction starts from the oxidative addition of aryl chlorides to Ni(0) and a difluoromethyl radical is involved in the reaction, providing a route for applications of ClCF2H in organic synthesis and related chem.
Nature Communications published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C2H4ClNO, Synthetic Route of 53731-26-3.
Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem