Month: November 2022

Gao, Lei published the artcileDevelopment and validation of a six-RNA binding proteins prognostic signature and candidate drugs for prostate cancer, COA of Formula: C20H17FO4S, the publication is Genomics (2020), 112(6), 4980-4992, database is CAplus and MEDLINE.

The dysregulation of RNA binding proteins (RBPs) regulates the progression of several cancers. However, information on the overall functions of RBPs in prostate cancer (PCa) remains largely understudied. Therefore, based on the TCGA dataset, this study identified 144 differentially expressed RBPs in tumors compared to normal tissues. Subsequently, through univariate, LASSO and multivariate Cox regression anal., 6 RBP genes among them, MSI1, MBNL2, LENG9, REXO2, RNASE1, and PABPC1L were screened as prognostic hub genes and prognostic signature was further identified. Further anal. indicated that the high-risk group was significantly associated with poor RFS, which was validated in the MSKCC cohort. Besides, patients in the high-risk group were closely associated with dysregulation of DNA damage repair pathway, copy number alteration, tumor burden mutation, and low-response to cisplatin (P lt 0.001), and bicalutamide (P lt 0.001). Using the Connectivity Map, we finally predicted 3 drugs including, ribavirin, carmustine, and carbenoxolone. In summary, we identified six-RBP gene signature and 3 potential drugs against PCa, which might promote the individualized treatment strategies and further improve the quality of life among PCa patients.

Genomics published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, COA of Formula: C20H17FO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Naher, Masnun published the artcileConjugated platinum-poly-ynes with extended arylene ethynylenes, Application of 9,10-Diethynylanthracene, the publication is Journal of Bangladesh Academy of Sciences (2015), 39(2), 195-202, database is CAplus.

The platinum-poly-yne polymers poly[trans-bis(tri-n-butylphosphine) platinum-poly(4,4′-diethynylenearylene)] (arylene = biphenylene 3 and anthracene 4) were synthesized by the condensation reaction between poly(diethynylenearylene) (arylene = biphenylene 1 and anthracene 2) and trans-[(PⁿBu₃)₂PtCl₂] in diisopropylamine and dichloromethane under nitrogen atm. in the presence of CuI catalyst. The newly synthesized platinum containing poly-yne polymers exhibit good solubility in common organic solvents. These metal linked polymers were characterized by IR, ¹H NMR and ³¹P NMR spectroscopy.

Journal of Bangladesh Academy of Sciences published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Application of 9,10-Diethynylanthracene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Colella, Silvia published the artcileMonodispersed molecular donors for bulk heterojunction solar cells: from molecular properties to device performances, Recommanded Product: 9,10-Diethynylanthracene, the publication is Chemical Communications (Cambridge, United Kingdom) (2010), 46(34), 6273-6275, database is CAplus and MEDLINE.

The relations between the chem.-phys. properties of novel designed monodispersed donors and their photovoltaic performances are discussed. The importance of intermol. interactions is emphasized to figure out the achievement of high performing bulk hetero-junction solar cells which are solution processed.

Chemical Communications (Cambridge, United Kingdom) published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Recommanded Product: 9,10-Diethynylanthracene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Cheng, Ka Wing published the artcileTopical phospho-sulindac (OXT-328) is effective in the treatment of non-melanoma skin cancer, Computed Properties of 59973-80-7, the publication is International Journal of Oncology (2012), 41(4), 1199-1203, database is CAplus and MEDLINE.

Phospho-sulindac (P-S, OXT-328), a novel sulindac derivative, has shown superior anticancer efficacy and safety compared to sulindac. In this study, we investigated the efficacy of topical P-S hydrogel in the treatment of non-melanoma skin cancer in preclin. models. P-S is a potent inhibitor of A431 epidermoid carcinoma in vitro and achieves this effect by inhibiting cell proliferation and inducing apoptosis. The anticancer efficacy of topical and oral P-S was further evaluated in mice bearing A431 intradermal xenografts. Compared to the controls, topical P-S hydrogel inhibited the A431 xenografts by 70.5% (p<0.01), while oral P-S inhibited it by 43.4% (p<0.05), being significantly less effective than topical P-S (p=0.017). Topical P-S hydrogel generated significant levels (>500 nmol/g tumor tissue) of intact P-S in the tumors, accounting for 92.5% of the total metabolites in the A431 xenografts. This local delivery of high levels of intact P-S to the A431 xenografts is an important contributor to the potent activity of topical P-S and no local or systemic side effects were noted in the treatment group. Thus, topical P-S is a promising treatment modality against non-melanoma skin cancer and merits further evaluation.

International Journal of Oncology published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Computed Properties of 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Moon, Eun-Yi published the artcileBenzylamide sulindac analogues induce changes in cell shape, loss of microtubules and G₂-M arrest in a chronic lymphocytic leukemia (CLL) cell line and apoptosis in primary CLL cells, Computed Properties of 59973-80-7, the publication is Cancer Research (2002), 62(20), 5711-5719, database is CAplus and MEDLINE.

Given our interest in cyclic nucleotide phosphodiesterase inhibitors in chronic lymphocytic leukemia (CLL), we studied the effects of sulindac sulfone (exisulind), a non-cyclooxygenase-inhibitory end metabolite of the NSAID sulindac that has been reported to inhibit cGMP phosphodiesterases. We focused on a novel benzylamide analog of sulindac sulfone, CP461, which is in clin. trials as a chemotherapeutic agent. As previously reported for colon carcinoma cell lines, we found that CP461 induced a rise in cGMP levels and blocked cell proliferation in the CLL cell line WSU-CLL. Surprisingly, however, cell cycle anal. revealed that CP461 caused G₂-M arrest with an EC₅₀ of 1.1 渭M. G₂-M arrest was associated with phosphorylation of Bcl2 (but not BAD, Bax, or Bcl-XL): both of these end points were abrogated by treatment with a calcium chelator. Although CP461 induces p53 up-regulation, G₂-M arrest and Bcl2 phosphorylation were independent of p53. Because microtubule-active drugs such as vincristine also induced G₂-M arrest and Bcl2 phosphorylation in WSU-CLL, whereas the genotoxic drugs etoposide and doxorubicin did not, we examined the effect of CP461 on microtubules by indirect immunofluorescence microscopy. CP461 eliminated microtubules rapidly, with reduction detected within 30 min of drug treatment. CP461 also induced marked changes in cell shape. Neither sulindac sulfide (a cyclooxygenase inhibitor) nor sulindac sulfone induced G₂-M arrest, Bcl2 phosphorylation, microtubule disassembly, or cell shape changes. Treatment with 30 渭M CP461 induced greater than 50% apoptosis in 10 of 10 primary CLL leukemic cell samples, whereas the same drug concentration had only marginal effects (14% apoptosis) on whole mononuclear cells. Our work demonstrates that addition of a benzylamide moiety to sulindac compounds results in markedly altered pharmacol. properties that may be of use in the therapy of lymphoid malignancies.

Cancer Research published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Computed Properties of 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Ermolaev, Nikolai L. published the artcileTris(trifluoromethyl)germylethynyl derivatives of biphenyl and anthracene: Synthesis, structure, and evidence of the intramolecular charge transfer on the germanium center, Category: naphthyridine, the publication is Journal of Organometallic Chemistry (2015), 83-95, database is CAplus.

Sym. and unsym. 4,4′-disubstituted 1,1′-biphenyl, and 9,10-anthracene derivatives with tris(trifluoromethyl)germylethynyl -C顚咰Ge(CF₃)₃ substituents have been prepared, their properties have been studied and compared with those of dimethyl(phenyl)silylethynyl -C顚咰Si(Ph)Me₂ compounds UV-visible absorption, steady-state, and time-resolved fluorescence spectra in solution for this germanium and silicon compounds have been investigated. The process of photoinduced electron-transfer from the aromatic group to the germanium center has been found in the unsym. 4-biphenyl -C顚咰Ge(CF₃)₃ mol. Anthracene derivatives with -C顚咰Ge(CF₃)₃ substituents have been characterized crystallog.

Journal of Organometallic Chemistry published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Category: naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Gu, Yang published the artcileCooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides, COA of Formula: C11H8F2, the publication is Nature Communications (2014), 5405, database is CAplus and MEDLINE.

A cooperative dual palladium/silver catalyst system for direct difluoromethylation of aryl bromides and iodides under mild conditions is reported. The system is developed by initial preparation of the putative intermediates in the dual-catalytic cycles, followed by studying the elemental steps to demonstrate the viability of the proposed cooperative catalytic cycle. The reaction is compatible with a variety of functional groups such as ester, amide, protected phenoxide, protected ketone, cyclopropyl, bromide, and heteroaryl subunits such as pyrrole, benzothiazole, carbazole or pyridine.

Nature Communications published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C11H8F2, COA of Formula: C11H8F2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Berton, Nicolas published the artcileCopolymer-Controlled Diameter-Selective Dispersion of Semiconducting Single-Walled Carbon Nanotubes, Product Details of C12H6F6O6S2, the publication is Chemistry of Materials (2011), 23(8), 2237-2249, database is CAplus.

The ability of a series of strictly alternating copolymers to selectively enwrap single-walled carbon nanotubes (SWNTs) is studied. Seven copolymers comprising either fluorene or carbazole subunits separated by naphthalene, anthracene, and anthraquinone spacers are obtained in good yields via a Suzuki cross-coupling protocol. The 1,5-linked naphthalene, anthracene, and anthraquinone units are introduced to favor a spiral conformation of the polymer backbone to improve its SWNT wrapping features. Particularly high yields of polymers are obtained using the naphthalene-1,5-ditriflate precursor, highlighting the potential of bifunctional aryltriflates as precursors of copolymers. All polymers disperse HiPco SWNTs in toluene. The obtained dispersions are purified by d. gradient centrifugation and their compositions are analyzed by photoluminescence (PL) spectroscopy. In their dispersing ability the polymers display more or less pronounced SWNT diameter selectivity. In particular, poly(9,9-didodecylfluorene-2,7-diyl-alt-anthracene-1,5-diyl) (P2) exhibits a strong selectivity toward SWNTs having a diameter of 鈮?.95 nm, including close-to-zigzag nanotubes. SWNT dispersions of P2 are further analyzed by absorbance and Raman scattering spectroscopy. The diameter selectivity is attributed to the anthracene-1,5-diyl subunit. In order to combine diameter selectivity with the preference for large chiral angles as shown by polyfluorene, the number of fluorene subunits in the polymer backbone is doubled in P7. Indeed, to some extent, the combination of both selectivities is observed in its dispersing behavior.

Chemistry of Materials published new progress about 152873-79-5. 152873-79-5 belongs to naphthyridine, auxiliary class Trifluoromethyl,Sulfonate,Benzene, name is 1,5-NAphthalenebis(trifluoromethanesulfonate), and the molecular formula is C12H6F6O6S2, Product Details of C12H6F6O6S2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Romeiro, Nelilma C. published the artcileSynthesis, pharmacological evaluation and docking studies of new sulindac analogues, Product Details of C20H17FO4S, the publication is European Journal of Medicinal Chemistry (2009), 44(5), 1959-1971, database is CAplus and MEDLINE.

This paper describes the synthesis, pharmacol. evaluation and docking studies of a series of new sulindac analogs. Overall, the designed compounds revealed good, in vivo, antinociceptive activity and satisfactory anti-inflammatory profile. Flexible mol. docking with COX-1/COX-2 has shown putative binding modes of the designed compounds while the theor. evaluation of cell permeability based on Lipinski’s rule of five has helped rationalize the biol. results.

European Journal of Medicinal Chemistry published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Product Details of C20H17FO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Webster, W. Scott published the artcileExisulind in the treatment of prostate cancer, Recommanded Product: Sulindac sulfone, the publication is Expert Review of Anticancer Therapy (2005), 5(6), 957-962, database is CAplus and MEDLINE.

A review. Prostate cancer represents the most common noncutaneous malignancy in men. With the widespread use of prostate-specific antigen screening, as many as one in six men in the USA will be diagnosed with prostate cancer. Significant healthcare resources are currently devoted to the treatment of this disease, specifically aimed at improving the side effects of successful treatment. Surgery or radiation therapy provides the best chance of cure from this disease. However, as many as 50% of patients treated with curative intent will develop a recurrence 10-15 years following treatment. Hormonal ablation via medical or surgical castration provides disease control, but is associated with significant hot flushes, loss of libido and impotence. Selective, apoptotic antineoplastic drugs, such as exisulind, may provide an alternative method to treating or preventing prostate cancer. This drug profile reviews the evidence for the use of exisulind in the treatment of prostate cancer.

Expert Review of Anticancer Therapy published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C5H5NO3S, Recommanded Product: Sulindac sulfone.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem