Month: November 2022

Fredenhagen, Andreas published the artcileEvaluation of the optimization space for atmospheric pressure photoionization (APPI) in comparison with APCI, COA of Formula: C20H17FO4S, the publication is Journal of Mass Spectrometry (2014), 49(8), 727-736, database is CAplus and MEDLINE.

The usefulness of atm. pressure photoionization (APPI) is difficult to evaluate for unknowns due to the fragmented literature. Specifically, the variation of dopants with a wide set of compounds or the use of APPI in the neg. mode have rarely been explored. Thirty compounds were selected that were not suitable for ESI with a wide variety of functional groups and investigated with atm. pressure chem. ionization (APCI) and APPI in the pos. and neg. ion modes. The influence of the mobile phase (eluents containing acetonitrile or methanol) and – for APPI – four different dopants (acetone, chlorobenzene, toluene, and toluene/anisole) were explored. Stepwise variation of the organic mobile phase allowed to elucidate the ionization mechanism. Atm. pressure photoionization was especially useful for compounds, where the M^鈥? and not the [M + H]⁺ was formed. The dopants chlorobenzene and anisole promoted the formation of mol. ions M^鈥? for about half of the compounds, and its formation was also pos. influenced by the use of mobile phases containing methanol. In the neg. ion mode, APPI offered no advantage toward APCI. Best results were generally achieved with the dopant chlorobenzene, establishing that this dopant is suitable for a wide set of compounds For one quarter of the compounds, significantly better results were achieved with mobile phases containing methanol for both APPI and APCI than those with acetonitrile, but only in the pos. mode. With either of the methods – APPI or APCI – about 10% of the compounds were not detected. Strategies to get results quickly with difficult unknowns will be discussed.

Journal of Mass Spectrometry published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, COA of Formula: C20H17FO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Kapetanovic, I. M. published the artcileEffects of oral dosing paradigms (gavage versus diet) on pharmacokinetics and pharmacodynamics, Category: naphthyridine, the publication is Chemico-Biological Interactions (2006), 164(1-2), 68-75, database is CAplus and MEDLINE.

In cancer chemopreventive studies, test agents are typically administered via diet, while the preclin. safety studies normally employ oral gavage dosing. Correspondence in pharmacokinetic and pharmacodynamic profiles between the two dosing approaches cannot be assumed a priori. Sulindac, a non-steroidal anti-inflammatory agent with potential chemopreventive activity, was used to assess effects of the two oral dosing paradigms on its pharmacokinetics and pharmacodynamics. Time-dependent concentrations of sulindac and its sulfone metabolite were determined in plasma and potential target organ, mammary gland. Prostaglandin E₂ was used as a pharmacodynamic biomarker and measured in mammary gland. An inverse linear relationship was detected between pharmacodynamic and pharmacokinetic markers, area under the curve for prostaglandin E₂ levels and sulindac sulfone concentrations, resp., in the mammary tissue. Marked differences in pharmacokinetics and pharmacodynamics were observed after administration of sulindac by the two oral dosing paradigms. In general, oral gavage resulted in higher peak and lower trough concentrations of sulindac in plasma and mammary tissue, higher area under concentration-time curve in plasma and mammary tissue, and greater effect on prostaglandin E₂ levels than the corresponding diet dosing. This study illustrates potential pitfalls and limitations in trying to generalize based on data obtained with different oral dosing schemes and their extrapolation to potential efficacy and health risks in humans.

Chemico-Biological Interactions published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Category: naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Paudler, William W. published the artcileSkraup synthesis and nuclear magnetic resonance spectra of some methylnaphthyridines, Recommanded Product: 2,7-Dimethyl-1,8-naphthyridine, the publication is Journal of Heterocyclic Chemistry (1967), 4(2), 284-9, database is CAplus.

Some mono- and dimethylnaphthyridines were prepared by the application of the Skraup reaction to various 2- and 4-aminopyridines. The proton N.M.R. spectral data assignments are reported. The chem. shifts of the Me protons are calculated

Journal of Heterocyclic Chemistry published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Recommanded Product: 2,7-Dimethyl-1,8-naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Paudler, William W. published the artcileNaphthyridine chemistry. VIII. Mass spectra of the 1,x-naphthyridines and some of their methyl derivatives, Name: 2,7-Dimethyl-1,8-naphthyridine, the publication is Journal of Heterocyclic Chemistry (1967), 4(4), 547-54, database is CAplus.

The mass spectra of the four parent 1,x-naphthyridines, the 2-, 3-, and 4-monomethyl-1,5-, 1,6-, and 1,8-naphthyridines, seven dimethyl-1,8-naphthyridines, and one trimethyl-1,8-naphthyridine are reported. Evidence for an azatropylium ion intermediate in the fragmentation of the methyl compounds is presented. The fragmentation modes of the naphthyridines are similar to those for the quinolines in addition to several new processes.

Journal of Heterocyclic Chemistry published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Name: 2,7-Dimethyl-1,8-naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Pangburn, Heather A. published the artcileSulindac metabolites inhibit epidermal growth factor receptor activation and expression, Related Products of naphthyridine, the publication is Journal of Carcinogenesis (2005), No pp. given, database is CAplus and MEDLINE.

Background: Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a decreased mortality from colorectal cancer (CRC). NSAIDs induce apoptotic cell death in colon cancer cells in vitro and inhibit growth of neoplastic colonic mucosa in vivo however, the biochem. mechanisms required for these growth inhibitory effects are not well defined. We previously reported that metabolites of the NSAID sulindac downregulate extracellular-signal regulated kinase 1/2 (ERK1/2) signaling and that this effect is both necessary and sufficient for the apoptotic effects of these drugs. The goal of this project was to specifically test the hypothesis that sulindac metabolites block activation and/or expression of the epidermal growth factor (EGF) receptor (EGFR). Methods: HT29 human colon cancer cells were treated with EGF, alone, or in the presence of sulindac sulfide or sulindac sulfone. Cells lysates were assayed by immunoblotting for phosphorylated EGFR (pEGFR, pY1068), total EGFR, phosphorylated ERK1/2 (pERK1/2), total ERK1/2, activated caspase-3, and 伪-tubulin. Results: EGF treatment rapidly induced phosphorylation of both EGFR and ERK1/2 in HT29 colon cancer cells. Pretreatment with sulindac metabolites for 24h blocked EGF-induced phosphorylation of both EGFR and ERK1/2 and decreased total EGFR protein expression. Under basal conditions, downregulation of pEGFR and total EGFR was detected as early as 12h following sulindac sulfide treatment and persisted through at least 48h. Sulindac sulfone induced downregulation of pEGFR and total EGFR was detected as early as 1h and 24h, resp., following drug treatment, and persisted through at least 72h. EGFR downregulation by sulindac metabolites was observed in three different CRC cell lines, occurred prior to the observed downregulation of pERK1/2 and induction of apoptosis by these drugs, and was not dependent of caspase activation. Conclusion: These results suggest that downregulation of EGFR signaling by sulindac metabolites may occur, at least in part, by inhibiting activation and expression of EGFR. Inhibition of EGFR signaling may account for part of the growth inhibitory and chemopreventive effects of these compounds

Journal of Carcinogenesis published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Related Products of naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Sfoungaristos, Stavros published the artcileNeoadjuvant chemotherapy prior to radical prostatectomy for patients with high-risk prostate cancer: a systematic review, Synthetic Route of 59973-80-7, the publication is Chemotherapy Research and Practice (2013), 386809, 7 pp., database is CAplus and MEDLINE.

High-risk prostate cancer represents a pretentious clin. problem since a significant number of its patients will relapse and progress after radical prostatectomy. Neoadjuvant chemotherapy may be valuable since its efficacy in hormone-resistant prostate cancer has been established. In this paper, we report studies of neoadjuvant chemotherapies that have been used in high-risk patients prior to radical prostatectomy. Even though the results regarding the prognostic surrogates are not significant, the effects on clin. and pathol. outcomes are promising, while toxicity in most of the studies is in the expected field.

Chemotherapy Research and Practice published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C42H63O3P, Synthetic Route of 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Li, Yongjun published the artcileIntramolecular triplet energy transfer in anthracene-based platinum acetylide oligomers, Category: naphthyridine, the publication is Journal of Physical Chemistry B (2013), 117(30), 9025-9033, database is CAplus and MEDLINE.

Platinum acetylide oligomers that contain an anthracene moiety have been synthesized and subjected to photophys. characterization. Spectroscopic measurement and DFT calculations reveal that both the singlet and triplet energy levels of the anthracene segment are lower than those of the platinum acetylide segment. Thus, the platinum acetylide segment acts as a sensitizer to populate the triplet state of the anthracene segment via intramol. triplet-triplet energy transfer. The objective of this work is to understand the mechanisms of energy-transfer dynamics in these systems. Fluorescence quenching and the dominant triplet absorption that arises from the anthracene segment in the transient absorption spectrum of Pt4An give clear evidence that energy transfer adopts an indirect mechanism, which begins with singlet-triplet energy transfer from the anthracene segment to the platinum acetylide segment followed by triplet-triplet energy transfer to the anthracene segment.

Journal of Physical Chemistry B published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Category: naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Belyaev, Andrey published the artcileSolution versus solid-state dual emission of the Au(I)-alkynyl diphosphine complexes via modification of polyaromatic spacers, Safety of 9,10-Diethynylanthracene, the publication is New Journal of Chemistry (2019), 43(35), 13741-13750, database is CAplus.

Single mol. luminophores capable of multiple emissions are essential for the development of new materials with unconventional photophys. behavior. In this work, a family of diphosphine ligands PPh₂-PAH-PPh₂ with variable polyaromatic hydrocarbon (PAH) spacers (PAH = 9,10-anthracene L1, 1,4-naphthalene L2, 2,6-naphthalene L3, and their diethynyl congeners L4–L6) were employed to prepare gold(I) complexes (RC₂Au)PPh₂-PAH-PPh₂(AuC₂R) (1–22), containing a selection of alkynyl groups. Investigation of their optical properties indicates that compounds with anthracene-based diphosphines (1–4 and 13–16) display only ¹IL (蟺蟺*) fluorescence with 桅_em up to 93%. The naphthalene and diethynyl-naphthalene diphosphine complexes (5–12 and 17–22), however, demonstrate panchromatic emission in the solid state and in solution featuring well-separated low and high energy signals, which originate from ¹IL (蟺蟺*) and ³IL (蟺蟺*) transitions along with certain contribution from metal to ligand and ligand to ligand charge transfers.

New Journal of Chemistry published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Safety of 9,10-Diethynylanthracene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Weber, E. published the artcileBenzo condensed crown ethers containing 1,8-naphthyridine or 4-pyridone units. Synthesis and complex formation with organic guest molecules, SDS of cas: 14903-78-7, the publication is Journal fuer Praktische Chemie/Chemiker-Zeitung (1995), 337(6), 451-5, database is CAplus.

New crown compounds, e.g., I, comprising, beside o-phenylene groups, 1,8-naphthyridine or 4-pyridone groups as characteristic building units are synthesized. They form numerous stoichiometric crystalline complexes with uncharged organic mols. including alcs., nitro compounds and other dipolar-aprotic solvents, as well as cyclic ethers and aromatic hydrocarbons. Properties of complex formation and host-guest stoichiometries are discussed in comparison with parent host analogs.

Journal fuer Praktische Chemie/Chemiker-Zeitung published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C26H41N5O7S, SDS of cas: 14903-78-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Jiang, Jian published the artcileNovel conjugated polymer containing anthracene backbone: the microstructure of polymer composed of 1,4-benzenedithiol with 9,10-diethynylanthracene and isomerization of the polymer and model compounds, COA of Formula: C18H10, the publication is Polymer Journal (Tokyo, Japan) (1990), 22(3), 274-82, database is CAplus.

In order to determine the microstructure of the polymer composed of 1,4-benzenedithiol with 9,10-diethynylanthracene, the model compounds cis– and trans-9,10-bis(phenylthiovinylene)anthracenes were prepared In comparison with the characteristic absorption peaks of vinylene in the model compounds, the microstructure of the polymer was evaluated. Regardless of the initiation mode, UV irradiation, AIBN and none, the cis contents of the polymers were 80-85%. The cis configuration of the polymer isomerized gradually to the trans one with increase of UV irradiation time. The characteristic features of the isomerization were also studied using model compounds The cis isomer of the model compound underwent irreversible isomerization to the trans one by UV irradiation In the presence of a radical source in the reaction system, both the cis and trans isomers can isomerize and reach an equilibrium state after reaction for a sufficient time. The isomerization mechanism was also discussed based on the potential energy diagram.

Polymer Journal (Tokyo, Japan) published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, COA of Formula: C18H10.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem