Month: November 2022

Zhang, Linlin published the artcileCross-conjugated spiro molecules and single-walled carbon nanotubes composite for high-performance organic thermoelectric materials and generators, Quality Control of 159-62-6, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2021), 131859, database is CAplus.

Organic thermoelec. materials have attracted tremendous attention in virtue of their unique advantages including low thermal conductivity, low cost, easy processability and mech. flexibility. Herein, a series of novel Spiro mols. are designed to be composited with single-walled carbon nanotubes (SWCNT) as p-type thermoelec. materials. An optimum power factor of 218.6μW m-1 K-2 is acquired from the SFX-2/SWCNT composite at room temperature The corresponding flexible thermoelec. generator containing 10p-type legs exhibits an output power of 1.0μW under a temperature gradient of 60 K. The high thermoelec. performance is attributable to the three dimensional cross-conjugated architecture of the Spiro mols., which promotes interactions with SWCNT leading to high carrier concentration and moderate carrier mobility in the composite film.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 159-62-6. 159-62-6 belongs to naphthyridine, auxiliary class Other Aromatic Heterocyclic,Spiro, name is Spiro[fluorene-9,9′-xanthene], and the molecular formula is C11H12O4, Quality Control of 159-62-6.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Ma, Qiang published the artcileOrganocatalytic orthogonal ATRP and ring-opening polymerization using a single dual-function photocatalyst, Safety of 2,2′-Dimethoxy-1,1′-binaphthalene, the publication is Polymer Chemistry (2022), 13(29), 4284-4289, database is CAplus.

Orthogonal catalysis is emerging as a powerful method for the synthesis of block copolymers. By employing a single designed dual-function photoredox phosphoric acid catalyst (Photo-PA), two types of polymerizations via different mechanisms, photo-triggered organocatalyzed atom transfer radical polymerization and acid-triggered ring-opening polymerization, can be effectively bridged, discriminated and performed simultaneously in one pot. This orthogonal system also features metal-free conditions, visible light regulation, the use of a single catalyst, as well as good compatibility and control, allowing the synthesis of block copolymers with the desired component and low dispersity in a one-pot approach and controlled manner.

Polymer Chemistry published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, Safety of 2,2′-Dimethoxy-1,1′-binaphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Wong, Benjamin Chun-Yu published the artcileCyclooxygenase-2 inhibitor (SC-236) suppresses activator protein-1 through c-Jun NH2-terminal kinase, Product Details of C20H17FO4S, the publication is Gastroenterology (2004), 126(1), 136-147, database is CAplus and MEDLINE.

Background & Aims: Aspirin exerts antitumor effect partly through blocking tumor promoter-induced activator protein-1 (AP-1) activation. The aim of this study is to determine how specific COX-2 inhibitor SC-236 mediates antitumor effect by modulation of AP-1-signaling pathway. Methods: AP-1 transcriptional activity and DNA-binding activity were detected by luciferase reporter assay and gel shift assay, sep. Mitogen-activated protein kinase (MAPK) activation was determined by Western blot and in vitro kinase assay. Antisense oligonucleotide against c-Jun-N-terminal kinase (JNK) was used to suppress JNK expression. Results: We showed that SC-236 inhibited 12-O-tetradecanoylphorbol-13-acetate (PMA)-induced cell transformation in a dose-dependent manner in JB6 cells. At a dose range (12.5-50 μmol/L) that inhibited cell transformation, SC-236 also inhibited anchorage-independent cell growth and AP-1-activation in 3 gastric cancer cells, independent of COX-prostaglandin synthesis. SC-236 down-regulated c-Jun-NH2-terminal kinase phosphorylation and activity. Suppression of JNK activity reversed the inhibitory effect on AP-1 activity by SC-236 and suppressed gastric cancer cell growth, indicating that the inhibitory effect of SC-236 on AP-1 activation and cell growth was through interaction with JNK. Conclusions: The inhibitory effect on JNK-c-Jun/AP-1 activation contributes to the antitumor effect of COX-2-specific inhibitor, and inhibition of JNK activation may have a therapeutic benefit against gastric cancer.

Gastroenterology published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C7H16N2, Product Details of C20H17FO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Shureiqi, Imad published the artcileThe 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-δ to induce apoptosis in colorectal cancer cells, Quality Control of 59973-80-7, the publication is Proceedings of the National Academy of Sciences of the United States of America (2003), 100(17), 9968-9973, database is CAplus and MEDLINE.

Diminished apoptosis, a critical event in tumorigenesis, is linked to down-regulated 15-lipoxygenase-1 (15-LOX-1) expression in colorectal cancer cells. 13-S-hydroxyoctadecadienoic acid (13-S-HODE), which is the primary product of 15-LOX-1 metabolism of linoleic acid, restores apoptosis. Nonsteroidal antiinflammatory drugs (NSAIDs) transcriptionally up-regulate 15-LOX-1 expression to induce apoptosis. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors for linoleic and arachidonic acid metabolites. PPAR-δ promotes colonic tumorigenesis. NSAIDs suppress PPAR-δ activity in colon cancer cells. The mechanistic relationship between 15-LOX-1 and PPAR-δ was previously unknown. Our current study shows that. (i) 13-S-HODE binds to PPAR-δ, decreases PPAR-δ activation, and down-regulates PPAR-δ expression in colorectal cancer cells;. (ii) the induction of 15-LOX-1 expression is a critical step in NSAID down-regulation of PPAR-δ and the resultant induction of apoptosis; and. (iii) PPAR-δ is an important signaling receptor for 13-S-HODE-induced apoptosis. The in vivo relevance of these mechanistic findings was demonstrated in our tumorigenesis studies in nude mouse xenograft models. Our findings indicate that the down-regulation of PPAR-δ by 15-LOX-1 through 13-S-HODE is an apoptotic signaling pathway that is activated by NSAIDs.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C3H9ClOS, Quality Control of 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Kobayashi, Eiichi published the artcileNovel conjugated polymer containing anthracene backbone: addition polymer of 9,10-diethynylanthracene with 9,10-anthracenedithiol and its properties, HPLC of Formula: 18512-55-5, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (1990), 28(10), 2641-50, database is CAplus.

9,10-Diethynylanthracene (I) was prepared by alk. hydrolysis of 9,10-bis(trimethylsilylethynyl)anthracene. Another monomer, 9,10-anthracenedithiol (II), was prepared by reduction of anthracene polydisulfide. A crystalline conjugated polymer (III) of I with II was synthesized in a THF solution at 50° by UV irradiation or using radical initiators. The number-average mol. weight of the insoluble III in THF was about 20000-30000 and the soluble was about 4000. Based on the S content and IR spectrum of the insoluble III, the obtained III had an alternating structure consisting of I and II units. X-ray patterns indicate that the polymer has a layered structure. The conductivity of undoped III was 10^-11 S/cm, but increased to 10^-6 S/cm by doping with iodine.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, HPLC of Formula: 18512-55-5.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Kobayashi, Eiichi published the artcileNovel conjugated polymer containing anthracene backbone: competitive addition polymerization of dithiol monomers to diethynyl monomers and relative reactivity, SDS of cas: 18512-55-5, the publication is Polymer Journal (Tokyo, Japan) (1990), 22(2), 146-52, database is CAplus.

Competitive addition polymerizations of 9,10-anthracenedithiol (I), 4,4′-biphenyl-dithiol(II), and 1,4-benzenedithiol (III) to 9,10-diethynylanthracene (IV), 4,4′-diethynylbiphenyl (V), and 1,4-diethynylbenzene (VI) were carried out in THF at 50° by UV irradiation under a nitrogen atm., and the relative reactivities of the monomers were discussed on the basis of composition anal. for the obtained polymers. To the dithiol monomers, the relative reactivities of the diethynyl monomers were in the order of IV > V > VI. The relative reactivities of dithiol monomers to the diethynyl monomers were in the order of I > II > III. This indicated that the more the monomer conjugation, the higher was the relative reactivity. The high reactivities of anthracene derivatives would be caused from stabilization of the intermediate carbon radical and thio radical by its high conjugation system.

Polymer Journal (Tokyo, Japan) published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, SDS of cas: 18512-55-5.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Kobayashi, Eiichi published the artcileNovel conjugated polymer containing anthracene backbone: addition polymers of 1,4-benzenedithiol with 9,10-diethynylanthracene and its conductivity, Formula: C18H10, the publication is Polymer Journal (Tokyo, Japan) (1990), 22(3), 266-73, database is CAplus.

The addition polymerization of 1,4-benzenedithiol to 9,10-diethynylanthracene, which was freshly prepared before use, was carried out in a THF and benzene solution at 50-60° under N atm. by various initiation methods such as UV irradiation, AIBN, and Bz₂O₂. The yield of polymer was affected seriously by the initiation mode. Both the yield and the mol. weight are higher for the polymer prepared by UV irradiation than that prepared by means of AIBN or Bz₂O₂. By UV irradiation, the yield of the polymer was âˆ?0%, and the number-average mol. weight of the polymer obtained in THF was âˆ?0,000, which was one order higher than that of the polymer obtained in benzene. The elec. conductivity of the polymer was on the order of 10^-13 Scm^-1 without doping, but increased up to 10^-6 Scm^-1 on I₂ doping. The diffuse reflectance spectra of the polymer indicated a relatively lower band gap (âˆ?.77 eV), and at 1.46 eV and 0.86 eV small peaks appeared, which could be attributed to a polaron or bipolaron in the polymer backbone.

Polymer Journal (Tokyo, Japan) published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Formula: C18H10.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Cao, Gui-Ping published the artcileRapid and environmentally friendly determination of trace nitrite in water under combined effects of cetyltrimethyl ammonium bromide and β-cyclodextrin, Category: naphthyridine, the publication is Desalination and Water Treatment (2019), 259-267, database is CAplus.

Nitrite is a characteristic pollutant in natural water. A simple, rapid and highly selective spectrofluorimetric method for determination of trace nitrite has been developed. It was based on the fact that nitrite reacted rapidly with iodide at room temperature and led to the fluorescence quenching of 4′,5′-dibromofluorescein (DBF) under the combined effects of cetyltrimethyl ammonium bromide (CTAB) and β-cyclodextrin (β-CD). The fluorescence intensity of the above reaction system was measured with excitation and emission wavelengths of 532 and 551 nm, resp. Optimal values of the main factors involving volumes of CTAB, β-CD and sulfuric acid were explored by a Box-Behnken design. Under the optimized exptl. conditions, the fluorescence quenching intensity was good linear over a nitrite concentration range of 0.2-46.0μg/L with a correlation coefficient better than 0.998. The detection limit of 0.16μg/L was obtained for the determination of nitrite by the proposed method. The general coexisting ions did not interfere to the reactions of nitrite with iodide and DBF. The relative standard deviation of the method for the determination of nitrite in water samples was below 2.7%, and the corresponding recoveries were between 92.1% and 107.9%. The proposed method is environmentally friendly and suitable for water monitoring.

Desalination and Water Treatment published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Category: naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Ou, Ya-Ping published the artcileSynthesis, Characterization, and Properties of Anthracene-Bridged Bimetallic Ruthenium Vinyl Complexes [RuCl(CO)(PMe₃)₃]₂(μ-CH:CH-anthracene-CH:CH), Name: 9,10-Diethynylanthracene, the publication is Organometallics (2011), 30(21), 5763-5770, database is CAplus.

Four anthracene-based bimetallic Ru vinyl complexes, in which two Ru units are attached at different positions (the 9,10-, 1,5-, 2,6-, and 1,8-positions) of the anthracene moiety, were synthesized by treating the appropriate anthracene-based ethynes with [RuHCl(CO)(PPh₃)₃]. These bimetallic complexes were thoroughly characterized by NMR, x-ray diffraction, and elemental anal. According to the single-crystal x-ray structures, the 2,6-disubstituted Ru vinyl complex has a more planar structure compared with the 9,10-disubstituted complex, possibly because it has less steric hindrance. Also, the optical electronic properties of these complexes were studied, such as their UV/visible absorption spectra, fluorescence spectra, and electrochem. properties. The optical electronic results indicated that the 2,6-disubstituted Ru vinyl complex displayed the strongest fluorescence emission due to the more planar structure of its organic conjugated bridge, and the electrochem. studies showed that the two Ru centers displayed obvious differences in electronic communication when they are located at different positions on the anthracene unit, with the 9,10- and 1,8-disubstituted Ru vinyl complexes exhibiting better electronic communication and higher stability of the mixed-valence complex than the 1,5- and 2,6-disubstituted complexes.

Organometallics published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Name: 9,10-Diethynylanthracene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Fu, Wen-Fu published the artcileSynthesis, characterization, photoinduced isomerization, and spectroscopic properties of vinyl-1,8-naphthyridine derivatives and their copper(I) complexes, Related Products of naphthyridine, the publication is Inorganic Chemistry (2010), 49(10), 4524-4533, database is CAplus and MEDLINE.

Acetylamino-substituted 2-pyridinylvinyl-1,8-naphthyridine ligands and their copper(I) phosphine mono- and binuclear complexes were prepared and characterized by x-ray crystal structure determination A series of 2-(2-pyridinylvinyl) 1,8-naphthyridine ligands, 7-acetamido-2-(6-acetamido-2-pyridinylethenyl)-4-methyl-1,8-naphthyridine (L¹), 2-(6-acetamido-2-pyridylethenyl)-1,8-naphthyridine (L²), 7-(6-acetamido-2-pyridinylethenyl)-5-methyl-1,8-naphthyridin-2(1H)-one (L³), 2-(2-diacetylamino-3-pyridinylethenyl)-7-(diacetylmethylene)-7,8-dihydro-1,8-naphthyridine (L⁴), and 2-(2-diacetylamino-3-pyridinylethenyl)-7-acetylpyrrolo[1,2-a]-1,8-naphthyridine (L⁵), as well as copper(I) phosphine complexes I, [CuL¹(PCy₃)](BF₄) (1, I·BF₄, M, Y¹ void, Y = tricyclohexylphosphine), [Cu₂L¹(PPh₃)₄](BF₄)₂ [2, I·2BF₄, M = Cu, Y = Y¹ = (PPh₃)₂,], [Cu₂L¹(dppm)](BF₄)₂ (3, I·2BF₄, M = Cu, Y-Y¹ = dppm), and [Cu₂(L¹)(dcpm)](BF₄)₂ [4, I·2BF₄, M = Cu, Y-Y¹ = bis(dicyclohexylphosphino)methane] were prepared All these compounds, except for L¹ and L², were characterized by single crystal x-ray diffraction anal., and a comprehensive study of their spectroscopic properties involving TD-DFT theor. calculations is presented. An intramol. 1,3-hydrogen transfer takes place during the formation of L³ and L⁴, which in the case of the latter plays an important role in the 1,5-dipolar cyclization into L⁵. The spectral changes that originate from an intramol. charge transfer (ICT) in the form of a π_py→π*_napy transition can be tuned through acid/base-controlled switching for L¹-L³. Ligands L¹-L³, complexes 1 and 2 undergo photochem. (E)-(Z)-double bond isomerization under 365 nm light irradiation due to their flexible structures. Quantum chem. calculations revealed that the dinuclear complexes with structural asymmetry exhibit different metal-to-ligand charge-transfer transitions.

Inorganic Chemistry published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Related Products of naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem