Month: November 2022

Zhou, Yi published the artcileBinaphthyl-containing green- and red-emitting molecules for solution-processable organic light-emitting diodes, HPLC of Formula: 2960-93-2, the publication is Advanced Functional Materials (2008), 18(20), 3299-3306, database is CAplus.

Strong intermol. interactions usually result in decreases in solubility and fluorescence efficiency of organic mols. Therefore, amorphous materials are highly pursued when designing solution-processable, electroluminescent organic mols. A nonplanar binaphthyl moiety is presented as a way of reducing intermol. interactions and four binaphthyl-containing mols. (BNCMs): green-emitting BBB and TBT as well as red-emitting BTBTB and TBBBT, are designed and synthesized. The photophys. and electrochem. properties of the mols. are systematically studied and TBT, TBBBT, and BTBTB solutions show high photoluminescence (PL) quantum efficiencies of 0.41, 0.54, and 0.48, resp. Based on the good solubility and amorphous film-forming ability of the synthesized BNCMs, double-layer structured organic light-emitting diodes (OLEDs) with BNCMs as emitting layer and poly(N-vinylcarbazole) (PVK) or a blend of poly[N,N’-bis(4-butylphenyl)-N,N’-bis(phenyl)benzidine] and PVK as hole-transporting layer are fabricated by a simple solution spin-coating procedure. Amongst those, the BTBTB based OLED, for example, reaches a high maximum luminance of 8315 cd m^-2 and a maximum luminous efficiency of 1.95 cd A^-1 at a low turn-on voltage of 2.2 V. This is one of the best performances of a spin-coated OLED reported so far. By doping the green and red BNCMs into a blue-emitting host material poly(9,9-dioctylfluorene-2,7-diyl) high performance white light-emitting diodes with pure white light emission and a maximum luminance of 4000 cd m^-2 are realized.

Advanced Functional Materials published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C51H42ClNOP2Pd, HPLC of Formula: 2960-93-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Kaminskaia, Natalia V. published the artcileReactivity of μ-Hydroxodizinc(II) Centers in Enzymatic Catalysis through Model Studies, Recommanded Product: 2,7-Dimethyl-1,8-naphthyridine, the publication is Inorganic Chemistry (2000), 39(15), 3365-3373, database is CAplus and MEDLINE.

The stable dinuclear complex [Zn₂(BPAN)(μ-OH)(μ-O₂PPh₂)](ClO₄)₂, where BPAN = 2,7-bis[2-(2-pyridylethyl)aminomethyl]-1,8-naphthyridine, was chosen as a model to investigate the reactivity of (μ-hydroxo)dizinc(II) centers in metallohydrolases. Two reactions, the hydrolysis of phosphodiesters and the hydrolysis of β-lactams, were studied. These two processes are catalyzed in vivo by the zinc(II)-containing enzymes P1 nuclease and β-lactamase, resp. P1 nucleases catalyze the hydrolysis of single-stranded DNA and RNA, while β-lactamases are expressed in many types of pathogenic bacteria and are responsible for the hydrolytic degradation of β-lactam antibiotic drugs. In the first step of phosphodiester hydrolysis promoted by the dinuclear model complex, the substrate replaces the bridging diphenylphosphinate. The bridging hydroxide serves as a general base to deprotonate water, which acts as a nucleophile in the ensuing hydrolysis. The dinuclear model complex is only 1.8 times more reactive in phosphodiester hydrolysis than a mononuclear analog, Zn(bpta)(OTf)₂, where bpta = N,N-bis(2-pyridylmethyl)-tert-butylamine. Hydrolysis of nitrocefin, a β-lactam antibiotic analog, catalyzed by [Zn₂(BPAN)(μ-OH)(μ-O₂PPh₂)](ClO₄)₂ involves monodentate coordination of the substrate via its carboxylate group, followed by nucleophilic attack of the zinc(II)-bound terminal hydroxide at the β-lactam carbonyl carbon atom. Collapse of the tetrahedral intermediate results in product formation. Mononuclear complexes Zn(cyclen)(NO₃)₂ and Zn(bpta)(NO₃)₂, where cyclen = 1,4,7,10-tetraazacyclododecane, are as reactive in the β-lactam hydrolysis as the dinuclear complex. Kinetic and mechanistic studies of the phosphodiester and β-lactam hydrolyzes indicate that the bridging hydroxide in [Zn₂(BPAN)(μ-OH)(μ-O₂PPh₂)](ClO₄)₂ is not very reactive, despite its low pK_a value. This low reactivity presumably arises from the two factors. First, the bridging hydroxide and coordinated substrate in [Zn₂(BPAN)(μ-OH)(substrate)]²⁺ are not aligned properly to favor nucleophilic attack. Second, the nucleophilicity of the bridging hydroxide is diminished because it is simultaneously bound to the two zinc(II) ions.

Inorganic Chemistry published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Recommanded Product: 2,7-Dimethyl-1,8-naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Mahapatra, Ajit K. published the artcileA highly sensitive and selective ratiometric fluorescent probe based on conjugated donor-acceptor-donor constitution of 1,8-naphthyridine for Hg²⁺, Computed Properties of 14903-78-7, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (2011), 222(1), 47-51, database is CAplus.

A new 1,8-naphthyridine based di-olefinic chemosensor was designed, synthesized and its sensing behavior towards metal ions was investigated by UV-vis, fluorescence and ¹H NMR spectroscopic methods. A highly Hg²⁺-selective fluorescence enhancing property (>1.5-fold) in conjunction with a visible colorimetric change from yellow to purple has been observed, leading to a potential fabrication of both “naked-eye” and fluorescence detection of Hg²⁺. Our designed sensor of the donor-acceptor-donor system shows high selectivity towards mercury(II) ion over other competing metal ions.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Computed Properties of 14903-78-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Faroughi Niya, Homayoun published the artcileSynthesis, characterization, and application of CoFe₂O₄@amino-2-naphthol-4-sulfonic acid as a novel and reusable catalyst for the synthesis of spirochromene derivatives, HPLC of Formula: 116-63-2, the publication is Applied Organometallic Chemistry (2021), 35(3), e6119, database is CAplus.

In the present work, 1-amino-2-naphthol-4-sulfonic acid immobilized on functionalized CoFe₂O₄ nanoparticles was successfully synthesized as a new, efficient, and recoverable catalyst and tested for the synthesis of spirochromene derivatives by a simple, green, and inexpensive procedure [e.g., isatin + malononitrile + dimedone â†?I (95%)]. This magnetically heterogeneous nanocatalyst was characterized by various techniques such as Fourier transform IR (FT-IR), thermal gravimetric anal. (TGA)/derivative thermogravimetric (DTG), X-ray diffraction (XRD), X-ray mapping, transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), vibrating sample magnetometer (VSM), Brunauer-Emmett-Teller (BET), and SEM analyses. The novel synthesized nanocatalyst can be easily separated and can also be reused several times without appreciable loss in its catalytic activity. Furthermore, in comparison with previous reports, this nanocatalyst showed high thermal stability and acidic properties.

Applied Organometallic Chemistry published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, HPLC of Formula: 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Takahashi, Ikko published the artcileBronsted acid-catalyzed tandem cycloaromatization of naphthalene-based bisacetals: selective synthesis of ortho-fused six-hexagon benzenoids, Quality Control of 152873-79-5, the publication is Chemistry Letters (2017), 46(3), 392-394, database is CAplus.

Naphthalenes bearing two acetal moieties connected by a methylene-2,1-phenylene group underwent regioselective tandem cycloaromatization using a catalytic amount of trifluoromethanesulfonic acid in 1,1,1,3,3,3-hexafluoropropan-2-ol. Five substrates were successfully employed in this protocol to afford ortho-fused six-hexagon benzenoids with high selectivities and in excellent yields.

Chemistry Letters published new progress about 152873-79-5. 152873-79-5 belongs to naphthyridine, auxiliary class Trifluoromethyl,Sulfonate,Benzene, name is 1,5-NAphthalenebis(trifluoromethanesulfonate), and the molecular formula is C12H9NO, Quality Control of 152873-79-5.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Gardner, S. H. published the artcileEffect of nonsteroidal anti-inflammatory drugs on β-catenin protein levels and catenin-related transcription in human colorectal cancer cells, Recommanded Product: Sulindac sulfone, the publication is British Journal of Cancer (2004), 91(1), 153-163, database is CAplus and MEDLINE.

Elevated β-catenin levels in human colorectal cancer (CRC) cells lead to increased trans-activation of ‘protumorigenic’ β-catenin/T-cell factor (TCF) target genes such as cyclin D1. Therefore, possible targets for the anti-CRC activity of nonsteroidal anti-inflammatory drugs (NSAIDs) are β-catenin and catenin-related transcription (CRT). We tested the antiproliferative activity and the effects on levels of β-catenin and cyclin D1 protein, as well as CRT (measured using a synthetic β-catenin/TCF-reporter gene [TOPflash]), of a panel of NSAIDs (indomethacin, diclofenac, sulindac sulfide and sulfone, rofecoxib; range 10-600 μM) on SW480 human CRC cells in vitro. Following NSAID treatment, there was no consistent relation between reduced cell proliferation, induction of apoptosis and changes in β-catenin protein levels or CRT. All the NSAIDs, except rofecoxib, decreased nuclear β-catenin content and cyclin D1 protein levels in parallel with their antiproliferative activity. However, cyclin D1 down-regulation occurred prior to a decrease in total β-catenin protein levels and there was no correlation with changes in CRT, suggesting the existence of CRT-independent effects of NSAIDs on cyclin D1 expression. In summary, NSAIDs have differential effects on β-catenin protein and CRT, which are unlikely to fully explain their effects on cyclin D1 and their antiproliferative activity on human CRC cells in vitro.

British Journal of Cancer published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Recommanded Product: Sulindac sulfone.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Dhamodharan, V. published the artcileSelective G-quadruplex DNA Stabilizing Agents Based on Bisquinolinium and Bispyridinium Derivatives of 1,8-Naphthyridine, Product Details of C10H10N2, the publication is Journal of Organic Chemistry (2012), 77(1), 229-242, database is CAplus and MEDLINE.

Various biol. relevant G-quadruplex DNA structures offer a platform for therapeutic intervention for altering the gene expression or by halting the function of proteins associated with telomeres. One of the prominent strategies to explore the therapeutic potential of quadruplex DNA structures is by stabilizing them with small mol. ligands. Here the synthesis of bisquinolinium and bispyridinium derivatives of 1,8-naphthyridine, e.g., I, and their interaction with human telomeric DNA and promoter G-quadruplex forming DNAs, is reported. The interactions of ligands with quadruplex forming DNAs were studied by various biophys., biochem., and computational methods. Results indicated that bisquinolinium ligands bind tightly and selectively to quadruplex DNAs at low ligand concentration (âˆ?.2-0.4 μM). Furthermore, thermal melting studies revealed that ligands imparted higher stabilization for quadruplex DNA (an increase in the T_m of up to 21 °C for human telomeric G-quadruplex DNA and >25 °C for promoter G-quadruplex DNAs) than duplex DNA (ΔT_m â‰?1.6 °C). Mol. dynamics simulations revealed that the end-stacking binding mode was favored for ligands with low binding free energy. Taken together, the results indicate that the naphthyridine-based ligands with quinolinium and pyridinium side chains form a promising class of quadruplex DNA stabilizing agents having high selectivity for quadruplex DNA structures over duplex DNA structures.

Journal of Organic Chemistry published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Product Details of C10H10N2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Shishimi, Toru published the artcileBrF₃-KHF₂: An air-stable fluorinating reagent, Related Products of naphthyridine, the publication is Journal of Fluorine Chemistry (2014), 55-60, database is CAplus.

BrF₃-KHF₂, an air-stable solid prepared from BrF₃ and KHF₂, was used in the various fluorination reactions, including desulfurizing fluorination reactions of benzylic sulfides, ketone and aldehyde dithioacetals, (phenylthio)glycosides, and tri-Me trithioorthocarboxylates. As the results, one to three fluorine atoms were selectively introduced to the substrates.

Journal of Fluorine Chemistry published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C6H12N2O, Related Products of naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Sun, Lilin published the artcileIndication of critical micelle concentration of nonionic surfactants with large emission change using water-soluble conjugated polymer as molecular light switch, Quality Control of 18512-55-5, the publication is Journal of Luminescence (2013), 260-265, database is CAplus.

A new near-IR water-soluble conjugated polymer, i.e. poly [2,5-di (propyloxysulfonate)-1,4-phenylene-ethynylene-9,10-anthrylene] (PPEASO3) was synthesized to investigate its interaction with surfactants. It was found that PPEASO3 has only a weak fluorescence emission at about 670 nm due to its self-aggregation in water and in aqueous solution containing a low concentration of nonionic surfactants, i.e. below their critical micelle concentration (CMC). However, a dramatic fluorescence enhancement with a large emission blue-shift (>40 nm) was found once the concentration of nonionic surfactants reached the CMC (especially for Triton X-100). An orange fluorescence could be observed even with naked-eyes under UV-lamp, which gave a direct indication for the micelle forming process and provided a simple method for the CMC determination of the nonionic surfactants. The CMC values determined by this method were in good agreement with those obtained by other techniques. The dramatic emission change observed could be ascribed to the intensive hydrophobic interaction between PPEASO3 and surfactants micelle, which greatly disrupts the aggregation of the polymer and increase the fluorescence efficiency of PPEASO3.

Journal of Luminescence published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C21H24O8, Quality Control of 18512-55-5.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Dawson, Nancy A. published the artcileA phase II study of estramustine, docetaxel, and exisulind in patients with hormone-refractory prostate cancer: results of cancer and leukemia group B trial 90004, Related Products of naphthyridine, the publication is Clinical Genitourinary Cancer (2008), 6(2), 110-116, database is CAplus and MEDLINE.

Docetaxel/estramustine is a known active regimen in hormone-refractory prostate cancer (HRPC). A phase II study was conducted to assess the safety and efficacy of docetaxel/estramustine combined with exisulind, an apoptotic antineoplastic drug. Eighty men with chemotherapy-naive HRPC were enrolled in a multicenter, cooperative group study. The treatment regimen consisted of oral estramustine (280 mg 3 times daily for 5 days), docetaxel 70 mg/m², oral exisulind (250 mg twice daily), oral dexamethasone (8 mg twice daily for 3 days), and oral warfarin (2 mg daily). Seventy-five eligible patients were treated with a median of 6 cycles of therapy. Forty-seven patients (62.7%; 95% CI, 50.7-73.6%) had a â‰?50% decline in prostate-specific antigen levels. Forty-six patients had measurable disease with 6 partial responses (13%; 95% CI, 4.9-26.3%). The main grade 3/4 toxicities were neutrophils (79%), fatigue (15%), and thrombosis/embolism (10%). The median time to first progression was 5.1 mo (95% CI, 4.4-6.3 mo) and the median survival time was 17.8 mo (95% CI, 14.7-20.1 mo). The combination of estramustine/docetaxel/exisulind was associated with significant thomboembolic toxicity despite prophylactic warfarin. The contribution of exisulind to toxicity is uncertain. Prostate-specific antigen decline, response rates, and progression-free and overall survival are similar to those reported with docetaxel/estramustine.

Clinical Genitourinary Cancer published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Related Products of naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem