Month: November 2022

Whitehead, Clark M. published the artcileExisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival, Computed Properties of 59973-80-7, the publication is Molecular Cancer Therapeutics (2003), 2(5), 479-488, database is CAplus and MEDLINE.

We reported previously a significant increase in survival of nude rats harboring orthotopic A549 human non-small cell lung cancer tumors after treatment with a combination of exisulind (Sulindac Sulfone) and docetaxel (D. C. Chan, Clin. Cancer Res., 8: 904-912, 2002). The purpose of the current study was to determine the biochem. mechanisms responsible for the increased survival by an anal. of the effects of both drugs on A549 orthotopic lung tumors and A549 cells in culture. Orthotopic A549 rat lung tissue sections from drug-treated rats and A549 cell culture responses to exisulind and docetaxel were compared using multiple apoptosis and proliferation analyses [i.e., terminal deoxynucleotidyl transferase-mediated nick end labeling, active caspase 3, the caspase cleavage products cytokeratin 18 and p85 poly(ADP-ribose) polymerase, and Ki-67]. Immunohistochem. was used to determine cGMP (cGMP) phosphodiesterase (PDE) expression in tumors. The cGMP PDE composition of cultured A549 cells was resolved by DEAE-Trisacryl M chromatog. and the pharmacol. sensitivity to exisulind, and addnl. known PDE inhibitors were determined by enzyme activity assays. Exisulind inhibited A549 cell cGMP hydrolysis and induced apoptosis of A549 cells grown in culture. PDE5 and 1 cGMP PDE gene family isoforms identified in cultured cells were highly expressed in orthotopic tumors. The in vivo apoptosis rates within the orthotopic tumors increased 7-8-fold in animals treated with the combination of exisulind and docetaxel. Exisulind increased the in vivo apoptosis rates as a single agent. Docetaxel, but not exisulind, decreased proliferative rates within the tumors. The data indicate that exisulind-induced apoptosis contributed significantly to the increased survival in rats treated with exisulind/docetaxel. The mechanism of exisulind-induced apoptosis involves inhibition of cGMP PDEs, and these results are consistent with a cGMP-regulated apoptosis pathway.

Molecular Cancer Therapeutics published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C6H12O2, Computed Properties of 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Atahan, Alparslan published the artcile1-Amino-2-hydroxy-4-naphthalenesulfonic acid based Schiff bases or naphtho[1,2-d]oxazoles: Selective synthesis and photophysical properties, Formula: C10H9NO4S, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (2015), 61-67, database is CAplus and MEDLINE.

A series of Schiff base and naphtho[1,2-d]oxazole derivatives were selectively synthesized via condensation reaction of 1-amino-2-hydroxy-4-naphthalenesulfonic acid and benzaldehyde derivatives at same conditions. The synthesized compounds were then characterized by using ¹HNMR, ¹³CNMR, FTIR spectroscopies and elemental analyses. It was seen that the Schiff bases e. g., I, generated in the presence of OH group at ortho position of benzaldehyde derivatives However, the products were naphtho[1,2-d]oxazoles e. g., II, in other cases. Then, the synthesized compounds were photophys. investigated by UV absorption and fluorescence emission spectroscopies. As a result, these Schiff bases have shown long wavelength absorption (λ_max: 386 nm) and emission (λ_max: 429-437 nm) effect while synthesized naphtho[1,2-d]oxazole derivatives have a set of absorption (λ_max: about 296, 308, 320 nm) and emission maxima (λ_max: 378-395 nm) at lower wavelength.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Formula: C10H9NO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Patil, A. A. published the artcilePeriodical status of plant available silicon as influenced by silicon extractants and levels of silicon in alkaline soils, Product Details of C10H9NO4S, the publication is International Journal of Chemical Studies (2017), 5(6Pt.C), 166-173, database is CAplus.

An incubation study was conducted by using calcium silicate as a source of silicon in alk. soils of order Inceptisols and Vertisols. The purpose of study was to know the periodical status of plant available silicon (PAS) as influenced by silicon extractants and levels of silicon in alk. soils. The experiment was laid out in factorial completely randomized design having seventy treatment combinations replicated thrice. The main treatments were ten silicon extractants and sub treatments were levels of silicon. The periodical status of PAS in Inceptisols and Vertisols showed bell shaped curve throughout incubation study. The PAS status increased from 0 to 40 day and then decreased from 60 to 100 day. The maximum PAS was recorded at 40 day. The silicon extractant 0.1 M Citric acid (1:50) and application of GRDF + Si @ 200 kg ha^-1 recorded significantly highest PAS status in Inceptisols and Vertisols throughout incubation study.

International Journal of Chemical Studies published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Product Details of C10H9NO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Li, Zhengyu published the artcileOne-Pot Synthesis of 3-Difluoromethyl Benzoxazole-2-thiones, HPLC of Formula: 116-63-2, the publication is Organic Letters (2018), 20(20), 6407-6410, database is CAplus and MEDLINE.

A one-pot strategy for the diversified synthesis of 3-difluoromethyl benzoxazole-2-thiones is reported. The reaction of 2-aminophenol, sodium chlorodifluoroacetate, and elemental sulfur in the presence of NaOt-Bu gives exclusively 3-difluoromethyl benzoxazole-2-thiones in good yield (up to 98%). The mechanism of this reaction presumably involves first cyclization of 2-aminophenols with thiocarbonyl fluoride, followed by N-difluoromethylation with difluorocarbene. The developed synthetic procedures are versatile, robust, and easily scalable for the synthesis of 3-difluoromethyl benzoxazole-2-thione derivatives, some of which have shown insecticidal activities.

Organic Letters published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, HPLC of Formula: 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Geng, Xin published the artcileThe Hairpin Furans: Easily Prepared Hybrids of Helicenes and Twisted Acenes, Application of 2,2′-Dimethoxy-1,1′-binaphthalene, the publication is Angewandte Chemie, International Edition (2015), 54(47), 13957-13960, database is CAplus and MEDLINE.

The thermal reaction of a cyclopentadienone with 6,6′-dimethoxy-5,5′-binaphthoquinone gives, in a single step, a mol. ribbon consisting of two twisted aromatic systems fused to a heteropentahelicene e. g., I. Such mols. constitute a new class of chiral polycyclic aromatic compounds, the “hairpin furans”.

Angewandte Chemie, International Edition published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, Application of 2,2′-Dimethoxy-1,1′-binaphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Yildiz, Resit published the artcileEvaluation of corrosion inhibition of mild steel in 0.1 M HCl by 4-amino-3-hydroxynaphthalene-1-sulfonic acid, HPLC of Formula: 116-63-2, the publication is Corrosion Science (2014), 215-221, database is CAplus.

The corrosion behavior of 4-amino-3-hydroxynaphthalene-1-sulfonic acid (4A3H1S) in 0.1 M HCl on mild steel (MS) was measured by electrochem. impedance spectroscopy (EIS), linear polarization resistance (LPR) and potentiodynamic measurements at various concentrations The surface morphol. of the MS was examined by SEM both in the absence of an inhibitor and in the presence of a 10 mM 4A3H1S-containing corrosive medium. The inhibition mechanism was determined by the potential of the zero charge (E_pzc) measurement at the solution-metal interface. The adsorption of 4A3H1S on the surface of MS obeyed the isotherm of Langmuir adsorption.

Corrosion Science published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H10CoF6P, HPLC of Formula: 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Wang, Qingxiang published the artcileA sensitive DNA biosensor based on a facile sulfamide coupling reaction for capture probe immobilization, Computed Properties of 116-63-2, the publication is Analytica Chimica Acta (2013), 158-164, database is CAplus and MEDLINE.

A novel DNA biosensor was fabricated through a facile sulfamide coupling reaction. First, the versatile sulfonic dye mol. of 1-amino-2-naphthol-4-sulfonate (AN-SO₃^–) was electrodeposited on the surface of a glassy carbon electrode (GCE) to form a steady and ordered AN-SO₃^– layer. Then the amino-terminated capture probe was covalently grafted to the surface of SO₃^–-AN deposited GCE through the sulfamide coupling reaction between the amino groups in the probe DNA and the sulfonic groups in the AN-SO₃^–. The step-by-step modification process was characterized by electrochem. and attenuated total reflectance Fourier transform IR (ATR-FTIR) spectroscopy. Using Ru(NH₃)₆³⁺ as probe, the probe d. and the hybridization efficiency of the biosensor were determined to be 3.18 × 10¹³ strands cm^-2 and 86.5%, resp. The hybridization performance of the biosensor was examined by differential pulse voltammetry using Co(phen)₃^3+/2+ (phen = 1,10-phenanthroline) as the indicator. The selectivity experiments showed that the biosensor presented distinguishable response after hybridization with the three-base mismatched, non-complementary and complementary sequences. Under the optimal conditions, the oxidation peak currents of Co(phen)₃^3+/2+ increased linearly with the logarithm values of the concentration of the complementary sequences in the range from 1.0 × 10^-13 M to 1.0 × 10^-8 M with a regression coefficient of 0.9961. The detection limit was estimated to be 7.2 × 10^-14 M based on 3σ.

Analytica Chimica Acta published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C17H14N2O2, Computed Properties of 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Li, Jing published the artcileA Significantly Twisted Spirocyclic Phosphine Oxide as a Universal Host for High-Efficiency Full-Color Thermally Activated Delayed Fluorescence Diodes, COA of Formula: C25H16O, the publication is Advanced Materials (Weinheim, Germany) (2016), 28(16), 3122-3130, database is CAplus and MEDLINE.

A novel spirocyclic phosphine oxide host 4′-diphenylphosphinoylspiro[fluorene-9,9′-xanthene] (SFXSPO) was constructed, from a short-axis linkage strategy. The amplified steric bulk of its Ph₂PO at the ortho-position effectively distorts the spiro[fluorene-9,9′-xanthene] (SFX) core, giving rise to the nonplanar xanthene and oblique fluorene. The extremely twisted, rigid, and asym. conformation of SFXSPO renders the highly disordered, mol. packing in its solid states, effectively mitigating intermol. interactions and facilitating uniform dispersion of the thermally-activated delayed fluorescence (TADF) dyes in its amorphous films. With the superiority in effectively suppressing the quenching effects induced by structural relaxation and dopant-dopant and host-dopant interactions, SFXSPO provided state-of the-art performance to its full-color devices, e.g., the record η_ext of 22.5% and 19.1% and η_int of 100% for its yellow TADF diodes and single-host full-TADF complementary nearly white devices, resp., manifesting SFXSPO as the best universal TADF host reported so far. The efficiency stability of its blue and nearly white TADF diodes, as well as spectral stability of its white organic LEDs, can be further improved when more efficient and stable blue TADF dyes are available, which leaves the space for further device optimization.

Advanced Materials (Weinheim, Germany) published new progress about 159-62-6. 159-62-6 belongs to naphthyridine, auxiliary class Other Aromatic Heterocyclic,Spiro, name is Spiro[fluorene-9,9′-xanthene], and the molecular formula is C25H16O, COA of Formula: C25H16O.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Yam, Chi Ming published the artcileFabrication of Self-Assembled Mono- and Multilayered Thin Films via Step-by-Step Deposition of Sn(NEt₂)₄ and Dialkyne Terminated Chromophores on Silica Based Surfaces, Recommanded Product: 9,10-Diethynylanthracene, the publication is Langmuir (2002), 18(22), 8481-8487, database is CAplus.

Acid-base hydrolytic chem. of surface anchored [Sn]-NEt₂ moieties with dialkyne terminated mols. has been used to construct close packed thin films of good structural quality on Si(100)/(Si/SiO₂) substrates. The surface coverage in these thin films was found to be 2-7 mols./100 Ų. An elaboration of this methodol. to a layer-by-layer deposition process using Sn(NEt₂)₄ and 1,9-decadiyne or p-diethynylbenzene led to thin film structures of up to five layers. The evolution of thin films in the step-by-step fabrication was monitored by contact angle goniometry, ellipsometry, XPS, FTIR-ATR, and UV-vis absorption spectroscopy. Topochem. polymerization on a thin film of p-bis(butadiynyl)benzene was achieved by exposure to UV-vis radiation, giving a blue film. Cobalt carbonyl could be easily adsorbed on these alkynyl thin films under room-temperature conditions.

Langmuir published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C3H7NO2, Recommanded Product: 9,10-Diethynylanthracene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Sall, Mohamed Lamine published the artcileRemoval of Cr(VI) from aqueous solution using electrosynthesized 4-amino-3-hydroxynaphthalene-1-sulfonic acid doped polypyrrole as adsorbent, SDS of cas: 116-63-2, the publication is Environmental Science and Pollution Research (2017), 24(26), 21111-21127, database is CAplus and MEDLINE.

Polypyrrole (PPy) conducting films, doped with 4-amino-3-hydroxynaphthalene sulfonic acid (AHNSA), were electrosynthesized by anodic oxidation of pyrrole on Pt and steel electrodes in aqueous medium (0.01 M AHNSA +0.007 M NaOH), using cyclic voltammetry (CV), and their electrochem. properties were studied. Fourier-transform IR (FT-IR) spectroscopy confirmed the formation of AHNSA-PPy films. Their morphol. was characterized by SEM (SEM), and their optical properties, including UV-VIS absorption and fluorescence spectra, were also investigated. AHNSA-PPy films were used for the removal of chromium(VI) from aqueous solution, by means of the immersion method and the Cr(VI) electro-reduction method. The effect of various exptl. parameters, including the adsorbent (polymer) mass, pH, type of electrodes, and current intensity, on the adsorption of chromium by the polymer was performed and optimized. The adsorption and electro-reduction of (Cr VI) on the AHNSA-PPy film surface were found to be highly pH-dependent, and the kinetics of Cr(VI) adsorption and electro-reduction followed second-order kinetic curves. Apparent second-order rate constants were about three times higher for the Cr(VI) electro-reduction method than for the immersion method, indicating that the use of electro-reduction method significantly accelerated the chromium adsorption process on polymer. The maximum adsorption capacity of the AHNSA-PPy film for chromium was 224 mg g^-1. A 96% chromium removal from pure aqueous solution was reached within about 48 h by the immersion method, but only within about 6 h by the Cr(VI) electro-reduction method. Application of both methods to Cr(VI) fortified natural waters of Senegal led to chromium removal efficiency high values (93 to 96% according to the type of natural water).

Environmental Science and Pollution Research published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, SDS of cas: 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem