Month: November 2022

Ribeiro, Marta F. T. published the artcileA multipumping flow system for in vitro screening of peroxynitrite scavengers, Computed Properties of 59973-80-7, the publication is Journal of Biomolecular Screening (2007), 12(6), 875-880, database is CAplus and MEDLINE.

Peroxynitrite anion is a reactive nitrogen species formed in vivo by the rapid, controlled diffusion reaction between nitric oxide and superoxide radicals. By reacting with several biol. mols., peroxynitrite may cause important cellular and tissue deleterious effects, which have been associated with many diseases. An automated flow-based procedure for the in vitro generation of peroxynitrite and subsequent screening of the scavenging activity of selected compounds is developed. This procedure involves a multipumping flow system (MPFS) and exploits the ability of compounds such as lipoic acid, dihydrolipoic acid, cysteine, reduced glutathione, oxidized glutathione, sulindac, and sulindac sulfone to inhibit the chemiluminescent reaction of luminol with peroxynitrite under physiol. simulated conditions. Peroxynitrite was generated in the MPFS by the online reaction of acidified hydrogen peroxide with nitrite, followed by a subsequent stabilization by merging with a sodium hydroxide solution to rapidly quench the developing reaction. The pulsed flow and the timed synchronized insertion of sample and reagent solutions provided by the MPFS ensure the establishment of the reaction zone only inside the flow cell, thus allowing maximum chemiluminescence emission detection. The results obtained for the assayed compounds show that, with the exception of oxidized glutathione, all are highly potent scavengers of peroxynitrite at the studied concentrations

Journal of Biomolecular Screening published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Computed Properties of 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Mirruzzo, Valentina published the artcileLow-Cost Synthesis of Hole Transporting Materials for Efficient Perovskite Solar Cells, Related Products of naphthyridine, the publication is Chem (2017), 2(5), 612-613, database is CAplus.

Given their high efficiency and easy fabrication procedures, perovskite solar cells are one of the most promising third-generation photovoltaic technologies. In this issue of Chem, Sun and colleagues identify a smart synthetic strategy for achieving efficient and low-cost hole transporting materials, a step forward for the success of this technol.

Chem published new progress about 159-62-6. 159-62-6 belongs to naphthyridine, auxiliary class Other Aromatic Heterocyclic,Spiro, name is Spiro[fluorene-9,9′-xanthene], and the molecular formula is C25H16O, Related Products of naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Goswami, Shyamaprosad published the artcileSide chain bromination of mono and dimethyl heteroaromatic and aromatic compounds by solid phase N-bromosuccinimide reaction without radical initiator under microwave, Synthetic Route of 14903-78-7, the publication is Chemistry Letters (2004), 33(7), 916-917, database is CAplus.

A series of side chain mono and dibromo derivatives of mono and di-Me heteroaromatic and aromatic compounds were synthesized by one step solid phase N-bromosuccinimide (NBS) reaction without radical initiator by microwave irradiation The benzylic mono and dibromo products were exclusively preferred except in the case of 6-methylpyridine amides where nuclear and side chain bromination resulted. Naphthyridine systems gave improved yields. Synthesis of 2-pivaloylaminopterin-6-carbaldehyde is reported.

Chemistry Letters published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Synthetic Route of 14903-78-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Rao, M. Rajeswara published the artcileπ-Extended Indenofluorenes, Application In Synthesis of 152873-79-5, the publication is Chemistry – A European Journal (2015), 21(16), 6193-6201, database is CAplus and MEDLINE.

A series of π-extended aromatic indenofluorene (IF) analogs with naphthalene and anthracene cores were synthesized through acid-catalyzed intramol. cyclization. The regioselectivity of the reaction is controlled by a combination of steric and electronic factors and in some cases several possible regioisomers have resulted from the same precursor. The effects of ring connectivity on the optoelectronic properties were studied by DFT calculations, absorption/emission spectroscopy, cyclic voltammetry, and spectroelectrochem. studies. All regioisomers exhibited a red shift of their absorption/emission bands relative to the parent IF analogs, but the magnitude of this shift and other optoelectronic properties (luminescence quantum yield, etc.) depends on the ring connectivity in a less obvious manner.

Chemistry – A European Journal published new progress about 152873-79-5. 152873-79-5 belongs to naphthyridine, auxiliary class Trifluoromethyl,Sulfonate,Benzene, name is 1,5-NAphthalenebis(trifluoromethanesulfonate), and the molecular formula is C12H6F6O6S2, Application In Synthesis of 152873-79-5.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Zhong, Yao published the artcileSulfonic acid functionalized hydrophobic mesoporous biochar: Design, preparation and acid-catalytic properties, Related Products of naphthyridine, the publication is Fuel (2019), 270-277, database is CAplus.

Sulfonic acid functional strong acidic catalysts are largely used in various chem. reactions. However, in many reactions with water as product, the catalytic activity and selectivity are unsatisfactory, because hydrophilic acid sites of SO₃H would suffer from acidity decreasing and some hydrolysis side reactions would occur via water adsorption. Herein, a novel hydrophobic arenesulfonic acid functionalized biochar was successfully prepared for the first time by one-pot diazo reduction method of biochar with amino-arenesulfonic acid (such as, 4-aminbenzenesulfonic acid, 4-amino-1-naphthalenesulfonic acid, 8-amino-1-naphthalenesulfonic acid, 4-amino-3-hydroxy-1-naphthalenesulfonic acid). It has a large sp. surface area of 200-400 m²/g, a hydrophobic network with water contact angle higher than 120° and a higher concentration of sulfonic acid over 1.0 mmol/g. Moreover, the hydrophobicity-oleophilicity and acidity are increased with the arene length and grafting amount of arenesulfonic acid. In the esterification reaction of fatty acid with methanol as well as the transesterification reaction of glycerol trioleate with methanol for the production of biodiesel, the sulfonated biochar shows a higher conversion of 96.7% for esterification and 86.3% for transesterification compared with amberlyst-15 (86.7%, 39.9%) and traditional sulfonation biochar-SO₃H (27.4%, 32.6%). In the alkylation reaction of 2-methylfuran with cyclopentanone for the production of high-d. biofuel, its catalytic efficiency with target product yield of 76.1% is higher than that of amberlyst-15 (50.2%) and traditional sulfonation biochar-SO₃H (13.2%), because of its hydrophobicity and strong acidity. Furthermore, the catalyst is stable and shows an excellent cycle performance after 6 runs. The successful preparation of hydrophobic biochar-based acidic catalysts not only provides a new way for high-value utilization of biochar, but also eliminates the neg. effect of water on many catalytic reactions.

Fuel published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C8H9NOS, Related Products of naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Kielar, Katarzyna published the artcileSynthesis of Sym-Phos {dicyclohexyl-[3-(2,4,6-trimethoxyphenyl)-4-methoxynaphth-2-yl]phosphine} ligand and its application in Suzuki-Miyaura reaction, SDS of cas: 2960-93-2, the publication is Chemik (2012), 66(6), 585-594, database is CAplus.

Authors present cheap, quick and efficient three-phase synthesis of air-resistant Sym-Phos ligand {dicyclohexyl[3-(2,4,6-trimethoxyphenyl)-4-methoxynaphth-2-yl]phosphine} of C,P-type complexes. Sym-Phos creates effective palladium catalysts to be used in difficult cases of cross-coupling reactions carried out under favorable conditions for the environment (water, unplugged flask, moderate temperature).

Chemik published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, SDS of cas: 2960-93-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Xiao, Danhua published the artcileThe sulindac derivatives OSI-461, OSIP486823, and OSIP487703 arrest colon cancer cells in mitosis by causing microtubule depolymerization, Product Details of C20H17FO4S, the publication is Molecular Cancer Therapeutics (2006), 5(1), 60-67, database is CAplus and MEDLINE.

Exisulind (sulindac sulfone) and three highly potent derivatives, OSI-461 (CP461), OSIP486823 (CP248), and OSIP487703, inhibit growth and induce apoptosis in SW480 human colon cancer cells, with IC₅₀s of 200, 2, 0.1, and 0.003 μmol/L, resp. The latter three compounds, but not exisulind, induce marked M-phase cell cycle arrest in these cells. This effect seems to be independent of the known ability of these compounds to cause activation of protein kinase G. When tested at twice their IC₅₀ concentration for growth inhibition, OSI-461, OSIP486823, and OSIP487703 cause depolymerization of microtubules in interphase cells, inhibit spindle formation in mitotic cells, and induce multinucleated cells. In vitro tubulin polymerization assays indicate that all three compounds interact with tubulin directly to cause microtubule depolymerization and/or inhibit de novo tubulin polymerization These results suggest that the dual effects of OSI-461, OSIP486823, and OSIP487703 on impairment of microtubule functions and protein kinase G activation may explain the potent antiproliferative and apoptotic effects of these compounds in cancer cells.

Molecular Cancer Therapeutics published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C12H15NO, Product Details of C20H17FO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Cen, Bo published the artcileActivation of Protein Kinase G Increases the Expression of p21^CIP1, p27^KIP1, and Histidine Triad Protein 1 through Sp1, Quality Control of 59973-80-7, the publication is Cancer Research (2008), 68(13), 5355-5362, database is CAplus and MEDLINE.

The anticancer role of cyclic guanosine 3′,5′-monophosphate (cGMP)-dependent protein kinase G (PKG) has become of considerable interest, but the underlying mechanisms are not fully established. In this study, we examined the effects of activation of PKG on the expression of three tumor suppressor proteins in human SW480 colon cancer cells. Our results revealed that treatment with cell permeable cGMP derivatives, or the cGMP phosphodiesterase inhibitor sulindac sulfone (exisulind, aptosyn, hereafter called exisulind) led to increased expression of the tumor suppressor proteins p21^CIP1, p27^KIP1, and Histidine triad protein 1 (HINT1), and their corresponding mRNAs. Overexpression of PKG Iβ also caused increased expression of the p21^CIP1, p27^KIP1, and HINT1 proteins. Both the p21^CIP1 and p27^KIP1 promoters contain Sp1 binding sites and they were activated by PKG in luciferase reporter assays. Specific Sp1 sites in the p21 and p27 promoters were sufficient to mediate PKG-induced luciferase reporter activity, suggesting an interaction between Sp1 and PKG. Indeed, we found that PKG can phosphorylate Sp1 on serine residue(s) and this resulted in transcriptional activation of Sp1. Knockdown of Sp1 expression with siRNA inhibited the increased expression of p21^CIP1, p27^KIP1, and HINT1 induced by the cGMP derivative 8-pCPT-cGMP in SW480 cells. These novel effects of PKG activation on the expression of three tumor suppressor genes may explain, at least in part, the anticancer effects of activation of PKG. They also provide a rationale for further developing activators of PKG for the prevention and treatment of cancer.

Cancer Research published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Quality Control of 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Chandler, Christopher J. published the artcileThe synthesis of macrocyclic polyether-diesters incorporating 1,10-phenanthrolino and 1,8-naphthyridino subunits, COA of Formula: C10H10N2, the publication is Journal of Heterocyclic Chemistry (1982), 19(5), 1017-19, database is CAplus.

Macrocycles I (n = 2-4) and II (n = 3, 4) were prepared by treating the resp. acid chlorides with HO(CH₂CH₂O)_nH. 2,7-Dimethylnaphthylridine was prepared in 60% yield from III by thermal rearrangement to ketone IV, followed by chlorination with POCl₃ and hydrogenolysis. III was obtained by treating 6-methyl-2-pyridinamine with MeCOCH₂CO₂Et.

Journal of Heterocyclic Chemistry published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, COA of Formula: C10H10N2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Pandey, Pragati published the artcileA Proton-Responsive Annulated Mesoionic Carbene (MIC) Scaffold on Ir Complex for Proton/Hydride Shuttle: An Experimental and Computational Investigation on Reductive Amination of Aldehyde, Application of 2,7-Dimethyl-1,8-naphthyridine, the publication is Organometallics (2020), 39(21), 3849-3863, database is CAplus.

A Cp^*Ir(III) complex (1) bearing a proton-responsive hydroxy unit on an annulated imidazo[1,2-a][1,8]naphthyridine based mesoionic carbene scaffold was synthesized by two different synthetic routes. The mol. structure of 1 revealed an anionic lactam form of the ligand. The acid-base equilibrium between the lactam-lactim tautomers on the ligand scaffold was examined by ¹H NMR and UV-visible spectra. The pK_a of the appendage -OH group in the lactim form of 1 was estimated to assess the proton transfer property of the catalyst. The catalytic efficacy of 1 for reductive amination of aldehyde was evaluated by using three different H sources: mol. H₂, ⁱPrOH/KO^tBu combination, and HCOOH/Et₃N (5:2) azeotropic mixture The HCOOH/Et₃N (5:2) azeotropic mixture protocol is the best among the three different hydrogenation methods. Catalyst 1 hydrogenates imines chemoselectively over carbonyls under the reaction conditions. A range of aldehydes was reductively aminated to the corresponding secondary amines using the HCOOH/Et₃N (5:2) azeotropic mixture Further, catalyst 1 showed high efficiency for the reduction of a wide variety of N-heterocyclic imine derivatives The lactam-lactim tautomerization of the ligand system is proposed for direct hydrogenation, whereas only the lactam form operates in the strongly basic medium (ⁱPrOH/KO^tBu). Under HCOOH/Et₃N (5:2) conditions, the lactam scaffold is not protonated; rather, an outer-sphere hydride transfer from formate to the Ir is proposed, which is supported by ¹H NMR and DFT calculations Finally, ligand-promoted hydride transfer from metal-hydride to the protonated imine affords the corresponding amine. A close agreement between the exptl. estimated and computed thermodn./kinetic parameters gives credence to the metal-ligand cooperative mechanism for the imine hydrogenation reaction using the HCOOH/Et₃N (5:2) azeotropic mixture

Organometallics published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Application of 2,7-Dimethyl-1,8-naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem