Month: November 2022

Bruce, Michael I. published the artcileSome platinum(II) complexes derived from aromatic alkynes, SDS of cas: 18512-55-5, the publication is Applied Organometallic Chemistry (2002), 16(10), 559-568, database is CAplus.

Several trans-platinum(II) complexes, of the type {trans-RPt(PBu₃)₂}-Q-{trans-Pt(PR₃)₂R}, where R and Q are groups derived from a series of aromatic alkynes and diynes, were prepared and characterized. Platination of trans-[(4-R¹-2,5-R²₂-C₆H₂CC)₂PtL₂] (L = PBu₃ or PTol₃; R² = H or OMe; R¹ = HCC) with trans-L₂PtCl₂ afforded trans-[ClPtL₂(CCC₆H₂-2,5-R²₂-4-CC)PtL₂(CCC₆H₂-2,5-R²₂-4-CC)PtL₂Cl], which were alkynylated by 4-(R³CC)(C₆H₂-2,5-R²₂)CCH (R³ = H, Ph) to give trinuclear bis-alkynylated platinum rod-like complexes. The same reaction of 1,4-diethynylarenes with subsequent alkynylation gave analogous binuclear complexes. Similar reaction led to trinuclear [trans-PtCl(PBu₃)(CCC₆H₄-4-CCPh)]₃[1,3,5-(CC)C₆H₃] complex. Coupling of trans-[(4-HCCC₆H₄CC)₂Pt(PBu₃)₂] with 4-IC₆H₄X (X = I, OH, NH₂, NO₂) gave corresponding trans-[(4-XC₆H₄CCC₆H₄CC)₂Pt(PBu₃)₂]. Spectroscopic data for these and other known related complexes are presented. A more precise structural study of trans-Pt(CCC₆H₄CCPh)₂(PBu₃)₂ is reported.

Applied Organometallic Chemistry published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, SDS of cas: 18512-55-5.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Bhattacharyya, Kalishankar published the artcilePolymorphism Controlled Singlet Fission in TIPS-Anthracene: Role of Stacking Orientation, Name: 9,10-Diethynylanthracene, the publication is Journal of Physical Chemistry C (2017), 121(3), 1412-1420, database is CAplus.

Generation of multiple triplet excitons from one singlet exciton (singlet fission, SF) has been reported in several organic mols. recently. The overall SF yield in such mol. materials, however, is controlled by polymorphism in organic semiconductors through noncovalent interactions like van der Waals and weak electrostatic interactions. In this article, we demonstrate how SF is strongly perturbed by even small variations in mol. packing for polymorphic crystals of triisopropylsilyethnyl-anthracene derivatives, TIPS-Ant (PI and PII). Based on quantum chem. calculations, SF dynamics have been computed for both PI and PII polymorphs. PI and PII differ in their intermol. π···π stacking patterns, which eventually control their electronic properties. Using the incoherent hopping model for the crystals, we computed SF rate through the Marcus electron transfer theory. For both PI and PII, the direct two-electron pathway predominates over the charge-transfer (CT) mediated mechanism. PII has higher triplet yield (âˆ?96%) compared to PI (âˆ?78%). Both time-dependent DFT as well as Weller equation reveal that the charge transfer (CT) state is a high energy state, and hence, CT mediated SF barely influences triplet yield. Interplay of the local excitation (LE), multiple excitation (ME), and correlated triplet (T₁T₁) energy levels controlled the overall exciton dynamics/diffusion in TIPS-Ant polymorphs. Polymorphism is shown to be a key factor for the rational design of optimal SF in polyaromatic hydrocarbons (PAH).

Journal of Physical Chemistry C published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Name: 9,10-Diethynylanthracene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Zerbini, Luiz F. published the artcileA Novel Pathway Involving Melanoma Differentiation Associated Gene-7/Interleukin-24 Mediates Nonsteroidal Anti-inflammatory Drug-Induced Apoptosis and Growth Arrest of Cancer Cells, HPLC of Formula: 59973-80-7, the publication is Cancer Research (2006), 66(24), 11922-11931, database is CAplus and MEDLINE.

Numerous studies show that nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in chemoprevention or treatment of cancer. Nevertheless, the mechanisms underlying these antineoplastic effects remain poorly understood. Here, we report that induction of the cancer-specific proapoptotic cytokine melanoma differentiation associated gene-7/interleukin-24 (MDA-7/IL-24) by several NSAIDs is an essential step for induction of apoptosis and G₂-M growth arrest in cancer cells in vitro and inhibition of tumor growth in vivo. We also show that MDA-7/IL-24-dependent up-regulation of growth arrest and DNA damage inducible 45 α (GADD45α) and GADD45γ gene expression is sufficient for cancer cell apoptosis via c-Jun NH₂-terminal kinase (JNK) activation and growth arrest induction through inhibition of Cdc2-cyclin B checkpoint kinase. Knockdown of GADD45α and GADD45γ transcription by small interfering RNA abrogates apoptosis and growth arrest induction by the NSAID treatment, blocks JNK activation, and restores Cdc2-cyclin B kinase activity. Our results establish MDA-7/IL-24 and GADD45α and GADD45γ as critical mediators of apoptosis and growth arrest in response to NSAIDs in cancer cells.

Cancer Research published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C7H5BFNO2, HPLC of Formula: 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Dell’Omo, Giulia published the artcileInhibition of SIRT1 deacetylase and p53 activation uncouples the anti-inflammatory and chemopreventive actions of NSAIDs, COA of Formula: C20H17FO4S, the publication is British Journal of Cancer (2019), 120(5), 537-546, database is CAplus and MEDLINE.

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been proposed as chemopreventive agents for many tumors; however, the mechanism responsible for their anti-neoplastic activity remains elusive and the side effects due to cyclooxygenase (COX) inhibition prevent this clin. application. Mol. biol., in silico, cellular and in vivo tools, including innovative in vivo imaging and classical biochem. assays, were applied to identify and characterize the COX-independent anti-cancer mechanism of NSAIDs. Here, we show that tumor-protective functions of NSAIDs and exisulind (a sulindac metabolite lacking anti-inflammatory activity) occur through a COX-independent mechanism. We demonstrate these NSAIDs counteract carcinogen-induced proliferation by inhibiting the sirtuin 1 (SIRT1) deacetylase activity, augmenting acetylation and activity of the tumor suppressor p53 and increasing the expression of the antiproliferative gene p21. These properties are shared by all NSAIDs except for ketoprofen lacking anti-cancer properties. The clin. interest of the mechanism identified is underlined by our finding that p53 is activated in mastectomy patients undergoing intraoperative ketorolac, a treatment associated with decreased relapse risk and increased survival. Our study, for the first-time, links NSAID chemopreventive activity with direct SIRT1 inhibition and activation of the p53/p21 anti-oncogenic pathway, suggesting a novel strategy for the design of tumor-protective drugs.

British Journal of Cancer published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, COA of Formula: C20H17FO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Trotta, Francesco published the artcileA straightforward synthesis in aqueous medium of enantiomerically enriched S-(-)-2,2′-dihydroxy-1,1′-binaphthyl, Recommanded Product: 2,2′-Dimethoxy-1,1′-binaphthalene, the publication is Environmental Science and Pollution Research International (2003), 10(3), 144-146, database is CAplus and MEDLINE.

Chiral, atropisomeric 2,2′-dihydroxy-1,1′-binaphthyl has been extensively used to direct asym. processes. Its key role in asym. catalysis has spurred efforts to synthesize it in the optically pure form, but the reported synthetic routes have a significant environmental impact. In an aqueous peroxidase-cyclodextrin system the oxidative coupling of 2-naphthol took place very rapidly in almost quant. yield and resulted in an enantiomeric excess. This one-pot synthesis does not require any organic solvents and oxidizing metal cations.

Environmental Science and Pollution Research International published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C18H34N4O5S, Recommanded Product: 2,2′-Dimethoxy-1,1′-binaphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Peluso, Paola published the artcileComparative HPLC Enantioseparation of Thirty-Six Aromatic Compounds on Four Columns of the Lux Series: Impact of Substituents, Shapes and Electronic Properties, HPLC of Formula: 2960-93-2, the publication is Chirality (2013), 25(11), 709-718, database is CAplus and MEDLINE.

With the aim to define a combined computational/chromatog. empirical approach useful for the HPLC method development of new chiral compounds, 36 racemic aromatic compounds with different chem. structures were used as test probes on four polysaccharide-based chiral stationary phases (CSPs) of the Lux series, Lux Cellulose-1, Lux Cellulose-2, Lux Cellulose-4, and Lux Amylose-2, using classical n-hexane/2-propanol mixtures as mobile phase. Electrostatic potential surfaces (EPSs) determined using D. Functional Theory (DFT) calculations were used to derive size, shape, and electronic properties of each analyte. Then a comparative HPLC screening was carried out to evaluate the impact of substituents, shapes, and electronic properties of the analytes on the chromatog. behavior as the column changes. The four CSPs showed good complementary recognition ability. The elution sequence was determined in 30 cases out of 36. The success rate to afford baseline separations (R_s â‰?1.5) was estimated: 29 compounds out of 36 showed baseline enantioseparation on at least one of the four selected CSPs. The combined computational-chromatog. screening furnished useful collective structure-chromatog. behavior relations and a map of the chiral discrimination abilities of the considered CSPs towards the analytes. On this basis, the chromatog. behavior of new analytes on a set of polysaccharide-based CSPs can be mapped through the qual. correlation of chromatog. parameters (k, α, R_s) to computed mol. properties of the analytes. Chirality 00:000-000, 2013. © 2013 Wiley Periodicals, Inc.

Chirality published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, HPLC of Formula: 2960-93-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Castanet, Anne-Sophie published the artcileAsymmetric Suzuki cross-coupling reaction: chirality reversal depending on the palladium-chiral phosphine ratio, Safety of 2,2′-Dimethoxy-1,1′-binaphthalene, the publication is Tetrahedron: Asymmetry (2002), 13(6), 659-665, database is CAplus.

Suzuki cross-coupling reaction with sterically hindered arylboronic acids is reported. Good yields are obtained by using DME and cesium fluoride in the presence of Pd(OAc)₂ and triphenylphosphine. The catalytic asym. reaction between 2-methoxy-1-naphthylboronic acid (I) and 1-iodo-2-methoxynaphthalene (II) was studied in the presence of a palladium-chiral phosphine catalyst. When the reaction was carried out with Pd(OAc)₂ and (R)-BINAP (vs. (R)-TolBINAP), the enantioselection was dramatically influenced by the phosphine/palladium ratio.

Tetrahedron: Asymmetry published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, Safety of 2,2′-Dimethoxy-1,1′-binaphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Entwistle, Christopher D. published the artcileSyntheses, structures, two-photon absorption cross-sections and computed second hyperpolarisabilities of quadrupolar A-π-A systems containing E-dimesitylborylethenyl acceptors, Application of 9,10-Diethynylanthracene, the publication is Journal of Materials Chemistry (2009), 19(40), 7532-7544, database is CAplus.

A series of bis(E-dimesitylborylethenyl)-substituted arenes, namely arene = 1,4-benzene, 1,4-tetrafluorobenzene, 2,5-thiophene, 1,4-naphthalene, 9,10-anthracene, 4,4′-biphenyl, 2,7-fluorene, 4,4′-E-stilbene, 4,4′-tolan, 5,5′-(2,2′-bithiophene), 1,4-bis(4-phenylethynyl)benzene, 1,4-bis(4-phenylethynyl)tetrafluorobenzene and 5,5”-(2,2′:5′,2”-terthiophene), have been synthesized via hydroboration of the corresponding diethynylarenes with dimesitylborane . Their absorption and emission maxima, fluorescence lifetimes and quantum yields are reported along with the two-photon absorption (TPA) spectra and TPA cross-sections for the 5,5′-bis(E-dimesitylborylethenyl)-2,2′-bithiophene and 5,5′-bis(E-dimesitylborylethenyl)-2,2′:5′,2”-terthiophene derivatives The TPA cross-section of the latter compound of ca. 1800 GM is the largest yet reported for a 3-coordinate boron compound and is in the range of the largest values measured for quadrupolar compounds with similar conjugation lengths. The X-ray crystal structures of 1,4-benzene, 2,5-thiophene, 4,4′-biphenyl and 5,5”-(2,2′:5′,2”-terthiophene) derivatives indicate π-conjugation along the BC:C-arene-C:CB chain. Theor. studies show that the second mol. hyperpolarisabilities, γ, in each series of compounds are generally related to the HOMO energy, which itself increases with increasing donor strength of the spacer. A strong enhancement of γ is predicted as the number of thiophene rings in the spacer increases.

Journal of Materials Chemistry published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Application of 9,10-Diethynylanthracene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Beher, Dirk published the artcileSelected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target γ-Secretase at a Novel Site: Evidence for an allosteric mechanism, Application In Synthesis of 59973-80-7, the publication is Journal of Biological Chemistry (2004), 279(42), 43419-43426, database is CAplus and MEDLINE.

γ-Secretase is a multi-component enzyme complex that performs an intramembranous cleavage, releasing amyloid-β (Aβ) peptides from processing intermediates of the β-amyloid precursor protein. Because Aβ peptides are thought to be causative for Alzheimer’s disease, inhibiting γ-secretase represents a potential treatment for this neurodegenerative condition. Whereas inhibitors directed at the active center of γ-secretase inhibit the cleavage of all its substrates, certain non-steroidal antiinflammatory drugs (NSAIDs) have been shown to selectively reduce the production of the more amyloidogenic Aβ(1-42) peptide without inhibiting alternative cleavages. In contrast to the majority of previous studies, however, we demonstrate that in cell-free systems the mode of action of selected NSAIDs and their derivatives, depending on the concentrations used, can either be classified as modulatory or inhibitory. At modulatory concentrations, a selective and, with respect to the substrate, noncompetitive inhibition of Aβ(1-42) production was observed At inhibitory concentrations, on the other hand, biochem. readouts reminiscent of a nonselective γ-secretase inhibition were obtained. When these compounds were analyzed for their ability to displace a radiolabeled, transition-state analog inhibitor from solubilized enzyme, noncompetitive antagonism was observed The allosteric nature of radioligand displacement suggests that NSAID-like inhibitors change the conformation of the γ-secretase enzyme complex by binding to a novel site, which is discrete from the binding site for transition-state analogs and therefore distinct from the catalytic center. Consequently, drug discovery efforts aimed at this site may identify novel allosteric inhibitors that could benefit from a wider window for inhibition of γ (42)-cleavage over alternative cleavages in the β-amyloid precursor protein and, more importantly, alternative substrates.

Journal of Biological Chemistry published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Application In Synthesis of 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Ju, Jin Uk published the artcileSynthesis and characterization of a new ethynyl-linked alternating anthracene/fluorene copolymer for organic thin film transistor, Synthetic Route of 18512-55-5, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2009), 47(6), 1609-1616, database is CAplus.

A new p-type conjugated copolymer, poly(9,10-diethynylanthracene-alt-9,9-didodecylfluorene) (PDADF), which is composed of ethynyl-linked alternating anthracene/fluorene, is synthesized via a palladium(II)-catalyzed Sonogashira coupling reaction with 9,10-diethynylanthracene and 2,7-diiodo-9,9-didodecyl-fluorene. The obtained polymer is confirmed by FTIR, ¹H-NMR, ¹³C-NMR and elemental anal. The PDADF had very good solubility in organic solvents such as chloroform and had a weight average mol. weight of 29,300 with a polydispersity index of 1.29. The PL maximum of the polymer was found at 533 and 568 nm for a solution and 608 nm for film, resp. The HOMO energy of the polymer is -5.62 eV as measured via cyclic voltammetry (CV). A solution-processed thin film transistor device showed a carrier mobility value of 6.0 × 10^-4 cm²/Vs with a threshold voltage of -17 V and a capacitance (C_i) of 10 nF/cm². The out-of-plane and in-plane GIXD pattern of spin-coated polymer on SiO₂ dielec. surfaces showed an amorphous halo near 2θ = 20°.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Synthetic Route of 18512-55-5.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem