Month: November 2022

Matsumi, Noriyoshi published the artcileSynthesis of novel σ-π conjugated polymers by alternating boration copolymerization between 1,2-diethynyl-1,1,2,2-tetramethyldisilane and aromatic diynes, Related Products of naphthyridine, the publication is Polymer Journal (Tokyo, Japan) (2001), 33(5), 383-386, database is CAplus.

Novel σ-π conjugated polymers were prepared by alternating boration copolymerization between 1,2-diethynyl-1,1,2,2-tetramethyldisilane and aromatic diynes using diphenylbromoborane. The gel permeation chromatog. anal. (GPC) showed that the number average mol. weights (M_n) of the obtained polymers were several thousands. For example, M_n of the polymer produced from 2,7-diethynylfluorene was 5700 (yield 30%). The polymers were soluble in common organic solvents such as THF, chloroform and dichloromethane. The polymer having the fluorene unit was moderately fluorescent. The structures of the polymers were supported by ¹H NMR, ¹¹B NMR, ²⁹Si NMR, and IR spectra.

Polymer Journal (Tokyo, Japan) published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Related Products of naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Mlynarska-Cieslak, Agnieszka published the artcileFluorinated Phosphoadenosine 5′-Phosphosulfate Analogs for Continuous Sulfotransferase Activity Monitoring and Inhibitor Screening by ¹⁹F NMR Spectroscopy, Computed Properties of 59973-80-7, the publication is ACS Chemical Biology (2022), 17(3), 661-669, database is CAplus and MEDLINE.

Sulfotransferases (STs) are ubiquitous enzymes that participate in a vast number of biol. processes involving sulfuryl group (SO₃) transfer. 3′-phosphoadenosine 5′-phosphosulfate (PAPS) is the universal ST cofactor, serving as the “active sulfate” source in cells. Herein, we report the synthesis of three fluorinated PAPS analogs that bear fluorine or trifluoromethyl substituents at the C2 or C8 positions of adenine and their evaluation as substitute cofactors that enable ST activity to be quantified and real-time-monitored by fluorine-19 NMR (¹⁹F NMR) spectroscopy. Using plant AtSOT18 and human SULT1A3 as two model enzymes, we reveal that the fluorinated PAPS analogs show complementary properties with regard to recognition by enzymes and the working ¹⁹F NMR pH range and are attractive versatile tools for studying STs. Finally, we developed an ¹⁹F NMR assay for screening potential inhibitors against SULT1A3, thereby highlighting the possible use of fluorinated PAPS analogs for the discovery of drugs for ST-related diseases.

ACS Chemical Biology published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Computed Properties of 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Deka, Manash Jyoti published the artcileTuning Electrical Properties of Graphene with Different π-Stacking Organic Molecules, Quality Control of 116-63-2, the publication is Journal of Physical Chemistry C (2016), 120(7), 4121-4129, database is CAplus.

Tuning of the elec. properties of graphene and functionalized graphene is very important to its use in optoelectronic devices. In this work, we study the elec. properties of graphene and graphene with different π-stacking organic mols. The different π-stacking organic mols. used in the present study were hemin, 1-amino 2-naphthol 4-sulfonic acid, and ferrocene. The noncovalently functionalized reduced graphene oxides were characterized by UV-visible spectroscopy, Fourier transformed IR spectroscopy, at. force microscopy, SEM, thermogravimetric anal., and Raman spectroscopy. The noncovalently functionalized reduced graphene oxide show higher ac conductivity than graphene oxide (GO). The enhancement of conductivity shown can be attributed to higher mobility, and the d. of π-electron and higher surface area of hybrid nanocomposites system. The reason is supported because that interaction of rGO with non-π-system like 18-crown-6 did not help in increasing the ac conductivity of the system. Thus, the elec. properties of graphene can be tuned through noncovalent interaction with π-stacking organic mols.

Journal of Physical Chemistry C published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Quality Control of 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Deka, Manash Jyoti published the artcileCVD Assisted Hydrophobic Graphene Quantum Dots: Fluorescence Sensor for Aromatic Amino Acids, Computed Properties of 116-63-2, the publication is ChemistrySelect (2017), 2(5), 1999-2005, database is CAplus.

In this paper, an hydrophobic graphene quantum dots(h-GQDs) based PL sensor was demonstrated which can distinguish between aromatic and non-aromatic amino acids. The h-GQDSs prepared using Chem. Vapor Deposition method from acetylene gas and hydrogen gas was used as cocatalyst. The characterization of h-GQDs was carried out by UV-Visible absorption spectrophotometer, Dynamic Light Scattering, SEM, Fourier Transform IR Spectrophotometer, Raman spectroscopy. These CVD assisted h-GQDs form stable dispersion in organic solvents and are hydrophobic in nature. It was observed that photoluminescence (PL) intensity of h-GQDs systems in the presence of aromatic amino acids is enhanced due to electron transfer from aromatic amino acids to h-GQDs whereas with non-aromatic amino acids PL intensity is quenched. Hence h-GQDs systems can selectively distinguish between aromatic and non-aromatic amino acid. The mechanistic insight is also discussed in the paper. Besides fluorescence sensors for aromatic amino acids, the h-GQDs system can also be used as a fluorescence hydrophobic coating material as when coated on glass substrate it shows very high contact angle (107°).

ChemistrySelect published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Computed Properties of 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Jia, Zhongjiang published the artcileDetermination of drug-polymer binding constants by affinity capillary electrophoresis for aryl propionic acid derivatives and related compounds, Name: Sulindac sulfone, the publication is Journal of Pharmaceutical Sciences (2013), 102(3), 960-966, database is CAplus and MEDLINE.

The binding constants (K_bs) of 17 aryl propionic acid derivatives (APADs) and related compounds with polyvinylpyrrolidone (PVP K30) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon VA64) in aqueous media were determined by affinity capillary electrophoreses (ACE). The K_bs of APAD to polymers increase with octanol-water partition coefficients of the compounds Kollidon VA64 is a stronger binder than PVP K30 to APAD compounds The K_bs are greater at pH 4 than at pH 9. Both hydrophobic interaction and hydrogen bonding may be involved. However, hydrophobic interaction appears to be dominant. The ACE method is simple and fast, which could be used to study drug-polymer interaction in aqueous media. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci.

Journal of Pharmaceutical Sciences published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Name: Sulindac sulfone.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Skowronski, Romuald published the artcileBenzenic and anthracenic hydrocarbons with unsaturated side chains, HPLC of Formula: 18512-55-5, the publication is Bulletin de la Societe Chimique de France (1967), 4235-43, database is CAplus.

Benzenic and anthracenic hydrocarbons having unsaturated side chains are obtained by aromatization of the corresponding dihydroaromatic diquinols in the presence of SnCl2 in MeOH or tetrahydrofuran at ambient temperature [TABLE OMITTED] In the case of polyacetylenic diols, the acetylenic diols are reacted with a 1-bromoacetylenic compound in the presence of MeOH, EtNH2, and CuCl. Condensation of ketones with alkynylarenes in the presence of KOH in tetrahydrofuran or N-methylpyrrolidone leads to the formation of acetylenic alcs. or diols. SnCl2/AcCl reduction of the diols in tetrahydrofuran furnishes quinoid biscumulenes, while catalytic partial reduction with Pd/CaCO3 in tetrahydrofuran or chem. partial reduction with LiAlH4 in tetrahydrofuran yields cis, cis diethylenic diols and trans, trans diethylenic diols, resp. The compounds prepared are given in the table.

Bulletin de la Societe Chimique de France published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C11H7ClFNO3, HPLC of Formula: 18512-55-5.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Tabor, Daniel P. published the artcileDesign rules for high mobility xanthene-based hole transport materials, Recommanded Product: Spiro[fluorene-9,9′-xanthene], the publication is Chemical Science (2019), 10(36), 8360-8366, database is CAplus and MEDLINE.

Tunable and highly conductive hole transport materials are crucial for the performance of organic electronics applications such as organic light emitting diodes and perovskite solar cells. For com. applications, these materials’ requirements include easy synthesis, high hole mobility, and highly tuned and compatible electronic energy levels. Here, we present a systematic study of a recently discovered, easy-to-synthesize class of spiro[fluorene-9,9′-xanthene]-based organic hole transport materials. Systematic side group functionalization allows us to control the HOMO energy and charge carrier mobility. Anal. of the bulk simulations enables us to derive design rules for mobility enhancement. We show that larger functional groups (e.g. methyl) decrease the conformational disorder due to steric effects and thus increase the hole mobility. Highly asym. or polar side groups (e.g. fluorine), however, increase the electrostatic disorder and thus reduce the hole mobility. These generally applicable design rules will help in the future to further optimize organic hole transport materials.

Chemical Science published new progress about 159-62-6. 159-62-6 belongs to naphthyridine, auxiliary class Other Aromatic Heterocyclic,Spiro, name is Spiro[fluorene-9,9′-xanthene], and the molecular formula is C5H6N2O2, Recommanded Product: Spiro[fluorene-9,9′-xanthene].

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Tai, Hsin-Hsiung published the artcileRegulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs), Computed Properties of 59973-80-7, the publication is Prostaglandins & Other Lipid Mediators (2011), 96(1-4), 37-40, database is CAplus and MEDLINE.

A review. NSAIDs are known to be inhibitors of cyclooxygenase-2 (COX-2) accounting for their anti-inflammatory and anti-tumor activities. However, the anti-tumor activity cannot be totally attributed to their COX-2 inhibitory activity as these drugs can also inhibit the growth and tumor formation of COX-2-null cell lines. Several potential targets aside from COX-2 for NSAIDs have been proposed. 15-Hydroxyprostaglandin dehydrogenase (15-PGDH), a key prostaglandin catabolic enzyme, was recently shown to be a tumor suppressor. Effects of NSAIDs on 15-PGDH expression were therefore studied. Flurbiprofen, indomethacin and other NSAIDs stimulated 15-PGDH activity in colon cancer HT29 cells as well as in lung cancer A549 cells and glioblastoma T98G cells. (R)-flurbiprofen and sulindac sulfone, COX-2 inactive analogs, also stimulated 15-PGDH activity indicating induction of 15-PGDH is independent of COX-2 inhibition. Stimulation of 15-PGDH expression and activity by NSAIDs was examined in detail in colon cancer HT29 cells using flurbiprofen as a stimulant. Flurbiprofen stimulated 15-PGDH expression and activity by increasing transcription and translation and by decreasing the turnover of 15-PGDH. Mechanism of stimulation of 15-PGDH expression is not clear. Protease(s) involved in the turnover of 15-PGDH remains to be identified. However, flurbiprofen down-regulated matrix metalloproteinase-9 (MMP-9) which was shown to degrade 15-PGDH, but up-regulated tissue inhibitor of metalloproteinase-1 (TIMP-1), an inhibitor of MMP-9 contributing further to a slower turnover of 15-PGDH. Taken together, NSAIDs may up-regulate 15-PGDH by increasing the protein expression as well as decreasing the turnover of 15-PGDH in cancer cells.

Prostaglandins & Other Lipid Mediators published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C10H16Br3N, Computed Properties of 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Zhao, Xi-Juan published the artcileSynthesis of novel pyrrolo[1′,5′-a]-1,8-naphthyridine derivatives through a facile one-pot process, Related Products of naphthyridine, the publication is Synthetic Communications (2007), 37(13), 2145-2152, database is CAplus.

Novel pyrrolo[1′,5′-a]-1,8-naphthyridine compounds were synthesized through a facile one-pot process by the reaction of the corresponding 1,8-naphthyridines with aliphatic anhydrides. The structures were established by spectroscopic data. Further X-ray crystal anal. of 4′-acetyl-7-methyl-pyrrolo[1′,5′-a]-1,8-naphthyridine identified its intriguing mol. structure and reveals the strong π-π stacking [triclinic, P-1, a 7.1455(12), b 8.2983(14), c 10.6337(17) Å, α 95(565)3, β 98.152(2), γ 103.957(3)°, V 600.06(17) ų, Z 2].

Synthetic Communications published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C15H14O3, Related Products of naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Liu, Huanhuan published the artcileRelationship of mineralization of amino naphthalene sulfonic acids by Fenton oxidation and frontier molecular orbital energies, Recommanded Product: 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2014), 275-282, database is CAplus.

Six amino naphthalene sulfonic acids including mono-, di- and tri-sulfonic acid compounds were studied to find the relationship between the reactivity of this kind of compounds in Fenton oxidation process and energies of the frontier MO. It was found that the initial rates of TOC reduction and oxalic acid production correlated strongly to the frontier MO energies and can be estimated by E_HOMO and the absolute electronegativity (χ). The cleavage of -SO₃H and -NH₂ groups to produce SO^2-₄ and NH⁺₄ species was dependent on the electron d. distribution on the -SO₃H moiety and the α-carbon atom connecting the -NH₂ moiety. The electron withdrawing effect of the -SO₃H groups influenced the mineralization of naphthalene sulfonic acids significantly. The naphthalene sulfonic acid with more -SO₃H groups was more recalcitrant to the Fenton oxidation

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Recommanded Product: 4-Amino-3-hydroxynaphthalene-1-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem