Month: November 2022

Wongma, Krittaphat published the artcileSynthesis of bridged biarylbisquinones and effects of biaryl dihedral angles on photo- and electro-chemical properties, HPLC of Formula: 2960-93-2, the publication is Tetrahedron (2016), 72(12), 1533-1540, database is CAplus.

A series of bridged biarylbisquinones, QBINOLs 1-4, and their corresponding monomers, QNaphs 5-6, were designed to demonstrate the influence of biaryl conformation on the photo- and electro-chem. properties of the mols. All target compounds were synthesized from the Diels-Alder reaction between silyl enol ethers of the corresponding naphthyl or binaphthyl derivatives and p-benzoquinone. Addition of an OMe auxochrome or formation of the dimeric structures affect the absorption spectra and the energy band gap (Eg), but not the reduction potentials of the mols. Narrowing the dihedral angles of the QBINOLs by shortening methylene bridges limited the contribution of bridging OR auxochromes and therefore resulted in lower HOMO levels and larger Eg.

Tetrahedron published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C5H5F3O2, HPLC of Formula: 2960-93-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Himmelstrup, Jonas published the artcileEnantioselective aryl-aryl coupling facilitated by chiral binuclear gold complexes, Recommanded Product: 2,2′-Dimethoxy-1,1′-binaphthalene, the publication is Chemical Communications (Cambridge, United Kingdom) (2019), 55(86), 12988-12991, database is CAplus and MEDLINE.

Herein, we report stoichiometric investigations embodying the first highly enantioselective aryl-aryl coupling facilitated by a gold complex. With up to 91% ee, this is the first demonstration of a transmetalation and C(sp²)-C(sp²) reductive elimination sequence with high enantioselectivity using a gold complex. The results offer a basis for development of enantioselective gold-catalyzed aryl-aryl coupling reactions.

Chemical Communications (Cambridge, United Kingdom) published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, Recommanded Product: 2,2′-Dimethoxy-1,1′-binaphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Shim, Heesung published the artcileThe trials and tribulations of structure assisted design of KCa channel activators, Category: naphthyridine, the publication is Frontiers in Pharmacology (2019), 972, database is CAplus and MEDLINE.

Calcium-activated K+ channels constitute attractive targets for the treatment of neurol. and cardiovascular diseases. To explain why certain 2-aminobenzothiazole/oxazole-type KCa activators (SKAs) are KCa3.1 selective we previously generated homol. models of the C-terminal calmodulin-binding domain (CaM-BD) of KCa3.1 and KCa2.3 in complex with CaM using Rosetta modeling software. We here attempted to employ this atomistic level understanding of KCa activator binding to switch selectivity around and design KCa2.2 selective activators as potential anticonvulsants. In this structure-based drug design approach we used RosettaLigand docking and carefully compared the binding poses of various SKA compounds in the KCa2.2 and KCa3.1 CaM-BD/CaM interface pocket. Based on differences between residues in the KCa2.2 and KCa.3.1 models we virtually designed 168 new SKA compounds The compounds that were predicted to be both potent and KCa2.2 selective were synthesized, and their activity and selectivity tested by manual or automated electrophysiol. However, we failed to identify any KCa2.2 selective compounds Based on the full-length KCa3.1 structure it was recently demonstrated that the C-terminal crystal dimer was an artifact and suggested that the “real” binding pocket for the KCa activators is located at the S4-S5 linker. We here confirmed this structural hypothesis through mutagenesis and now offer a new, corrected binding site model for the SKA-type KCa channel activators. SKA-111 (5-methylnaphtho[1,2-d]thiazol-2-amine) is binding in the interface between the CaM N-lobe and the S4-S5 linker where it makes van der Waals contacts with S181 and L185 in the S45A helix of KCa3.1.

Frontiers in Pharmacology published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C6H4ClNO2, Category: naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Krier, Fabrice published the artcileOptimisation and validation of a fast HPLC method for the quantification of sulindac and its related impurities, Category: naphthyridine, the publication is Journal of Pharmaceutical and Biomedical Analysis (2011), 54(4), 694-700, database is CAplus and MEDLINE.

The European Pharmacopoeia describes a liquid chromatog. (LC) method for the quantification of sulindac, using a quaternary mobile phase including chloroform and with a rather long run time. In the present study, a new method using a short sub-2 μm column, which can be used on a classical HPLC system, was developed. The new LC conditions (without chloroform) were optimized by means of a new methodol. based on design of experiments in order to obtain an optimal separation Four factors were studied: the duration of the initial isocratic step, the percentage of organic modifier at the beginning of the gradient, the percentage of organic modifier at the end of the gradient and the gradient time. The optimal condition allows the separation of sulindac and of its 3 related impurities in 6 min instead of 18 min. Finally, the method was successfully validated using an accuracy profile approach in order to demonstrate its ability to accurately quantify these compounds

Journal of Pharmaceutical and Biomedical Analysis published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Category: naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Geto, Alemnew published the artcileElectrochemical synthesis, characterisation and comparative study of new conducting polymers from amino-substituted naphthalene sulfonic acids, Formula: C10H9NO4S, the publication is Journal of Solid State Electrochemistry (2016), 20(11), 2969-2979, database is CAplus.

Conducting polymers have been synthesized electrochem. from 4-amino-3-hydroxynaphthalene-1-sulfonic acid (4A3HN1SA), 4-aminonaphthalene-1-sulfonic acid (4AN1SA) and 7-amino-4-hydroxynaphthalene-2-sulfonic acid (7A4HN2SA) on glassy carbon electrodes. The influence of the pos. potential limit on the potential cycling polymerization of 4A3HN1SA was studied, and a sufficiently high potential limit allowed better film growth. Under similar polymerization conditions, the three monomers showed different radical formation potentials and different voltammetric peak profiles. The effects of scan rate and solution pH on the electrochem. properties of the polymers were investigated, in the range between 10 and 200 mV s^-1, all the modified electrodes showing a surface-confined electrode process. In the pH range from 2.0 to 9.0, the anodic peak potentials decreased linearly with increasing pH for all the three modified electrodes. The modified electrodes were characterized by electrochem. impedance spectroscopy in pH 4.0 and 7.0 buffer solutions The results showed a more porous poly(7A4HN2SA) film, which is less affected by pH change than the other two films. SEM of the polymer films also showed significant differences in their morphologies.

Journal of Solid State Electrochemistry published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Formula: C10H9NO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Coghlan, Daniel R. published the artcileSynthesis and antibacterial activity of some binaphthyl-supported macrocycles containing a cationic amino acid, COA of Formula: C22H18O2, the publication is Bioorganic & Medicinal Chemistry (2011), 19(11), 3549-3557, database is CAplus and MEDLINE.

As part of a program investigating antibacterial cyclic macrocycles containing a cationic amino acid with an internal aromatic hydrophobic scaffold, we previously reported a macrocycle anchored at the 3,3′-positions of a 1,1′-binaphthyl unit. This was prepared via key intermediates containing an internal allylglycine and an allyl-substituted binaphthyl unit for a subsequent ring-closing metathesis reaction. This study presents some structure-activity relationship studies with addnl. macrocycles based on this lead compound against Staphylococcus aureus together with the antibacterial activity of 2 related acyclic compounds

Bioorganic & Medicinal Chemistry published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, COA of Formula: C22H18O2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Hendricker, David G. published the artcileComplexes of 1,8-naphthyridines. III. Transition metal-perchlorate complexes of 2,7-dimethyl-1,8-naphthyridine, Product Details of C10H10N2, the publication is Inorganic Chemistry (1970), 9(2), 273-7, database is CAplus.

A number of transition metal-perchlorate complexes of the type ML3(ClO4)2 (M = Fe, Cu, Ni, Co, Zn, and Cd), HgL2(ClO4)2, and AgL2Cl o4, where L = 2,7-dimethyl-1,8-naphthyridine, have been synthesized. Elemental analyses, molar conductances, magnetic moments, and IR and electronic spectral data have been applied to the characterization of the compounds The resulting ligand field parameters place the present ligand nearer pyridine than 1,10-phenanthroline and 2,2-bipyridine in the spectrochem. series. Since the latter 2 are very similar in basicity and synergic bonding to L, the resulting weak ligand field property is attributed to strain produced in the formation of a 4-member chelate ring system.

Inorganic Chemistry published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Product Details of C10H10N2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Zhang, Yi-Qi published the artcileUnusual Deprotonated Alkynyl Hydrogen Bonding in Metal-Supported Hydrocarbon Assembly, COA of Formula: C18H10, the publication is Journal of Physical Chemistry C (2015), 119(17), 9669-9679, database is CAplus.

The authors demonstrate that terminal alkynyl moieties represent powerful functional groups for driving thermally stable, on-surface supramol. structure formation on a reactive substrate. Through a combination of scanning tunneling microscopy, XPS spectra, near-edge X-ray absorption-fine-structure spectra, and d. functional theory calculations, the mol.-surface interaction and self-assembly of two prototypical hydrocarbon species on Cu(111) were investigated. For 1,3,5-tris(4-ethynylphenyl)benzene (Ext-TEB) adsorption at low temperature (200 K) resulted in nonassembling, conformationally adapted intact species. Deprotonation of the terminal alkyne moieties, taking place at temperatures ranging from 300 to 350 K, triggered the formation of room-temperature stable, close-packed supramol. islands. Through DFT calculations, the stabilizing interaction was identified as a trifurcated ionic C-H···π^-δ hydrogen bonding between the π-system of the ionic alkynyl groups and methine moieties of nearby benzene rings, providing an energy gain of 0.26 eV/mol. upon network formation. Robust assemblies result from the combination of this weak directional attraction with the strong surface anchoring also provided by the alkynyl groups. The generality of this ionic hydrogen-bonding type is demonstrated by the observation of low-dimensional assemblies of 9,10-diethynyl-anthracene on the same surface, consistently explained with the same type of interaction.

Journal of Physical Chemistry C published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C26H26N4O7, COA of Formula: C18H10.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Allsup, Jodie published the artcileApplicability domain of the GADD45a reporter assays: non-steroidal anti-inflammatory drugs do not produce misleading genotoxicity results, SDS of cas: 59973-80-7, the publication is Toxicology Research (Cambridge, United Kingdom) (2013), 2(5), 343-351, database is CAplus.

Increased expression of the GADD45a gene is a very specific biomarker of genotoxin exposure in TK6 cells, and has been exploited in green fluorescent protein and luciferase reporter genotoxicity assays. A recent European Food Safety Authority suggested that the GADD45a-reporter genotoxicity assays might produce misleading pos. results for non-steroidal anti-inflammatory drugs. This study was conceived to test the hypothesis that these drugs should be excluded from the applicability domain of the TK6 cell GADD45a GreenScreen HC and BlueScreen HC reporter assays. Data from published screening and validation studies have been reviewed, and new test data have been generated from 20 NSAIDS, from both reporter assays, both in the presence and absence of metabolic activation. The data fail to support this hypothesis: the high specificity of the GADD45a reporter assays is maintained amongst NSAIDs.

Toxicology Research (Cambridge, United Kingdom) published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, SDS of cas: 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Manivannan, Dhanasekaran published the artcileSynthesis and chelation properties of a new polymeric ligand derived from 1-amino-2-naphthol-4-sulfonic acid, Product Details of C10H9NO4S, the publication is Journal of AOAC International (2015), 98(1), 188-191, database is CAplus and MEDLINE.

A novel chelating resin for preconcentration of heavy metals from various seawater samples has been developed by condensing 1-amino-2-hydroxy-7-[(4-hydroxyphenyl)diazenyl] naphthalene-4-sulfonic acid (AHDNS) with formaldehyde (1:2 mol ratio) in the presence of oxalic acid as the catalyst. The resin obtained was used as a solid sorbent for the separation of divalent metal ions present at trace levels in seawater. The functionalized phenol (AHDNS) was characterized by spectral studies. The polymeric resin AHDNS-formaldehyde (AHDNS-F) obtained by condensing the functionalized phenol and formaldehyde was characterized by IR and NMR spectral studies. The chelating property of the AHDNS-F resin towards divalent metal ions was studied as a function of pH and in the presence of electrolyte. The metal uptake properties of the resin were determined by using an at. absorption spectrophotometer. This procedure was validated for recovery of divalent metal ions from seawater samples. The recovery of cadmium, cobalt, copper, manganese, lead, and zinc were above 92% under the optimum preconcentration conditions. The LOD was <0.73 μg/L and the RSDs were <2%. Thus, the AHDNS-F resin can be widely used as a solid sorbent for the preconcentration of trace metals at ppm levels in seawater samples.

Journal of AOAC International published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Product Details of C10H9NO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem