Month: November 2022

Xu, Bo published the artcileA low-cost spiro[fluorene-9,9′-xanthene]-based hole transport material for highly efficient solid-state dye-sensitized solar cells and perovskite solar cells, Product Details of C25H16O, the publication is Energy & Environmental Science (2016), 9(3), 873-877, database is CAplus.

A low-cost spiro[fluorene-9,9′-xanthene] (SFX) based organic hole transport material (HTM) termed X60 was designed and synthesized using a two-step synthetic route. Devices with X60 as HTM showed high power conversion efficiencies (PCEs) amounting to 7.30% in solid-state dye-sensitized solar cells (ssDSCs) and 19.84% in perovskite solar cells (PSCs), under 100 mW cm^-2 AM1.5G solar illumination. To the best of our knowledge, this is the first example of an easily synthesized spiro-structured HTM that shows comparable performance with respect to the well-known HTM Spiro-OMeTAD in both ssDSCs and PSCs. Furthermore, the facile synthesis of X60 from com. available starting materials makes this HTM very promising for large-scale industrial production in the future.

Energy & Environmental Science published new progress about 159-62-6. 159-62-6 belongs to naphthyridine, auxiliary class Other Aromatic Heterocyclic,Spiro, name is Spiro[fluorene-9,9′-xanthene], and the molecular formula is C5H10O2S, Product Details of C25H16O.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Sanyal, Utpal published the artcileLiquid chromatographic separation of derivatives of diospyrin, a bioactive bisnaphthoquinonoid plant-product, and analogous naphthyl compounds, SDS of cas: 2960-93-2, the publication is Journal of Chromatography A (2003), 1017(1-2), 225-232, database is CAplus and MEDLINE.

Isocratic reversed-phase liquid chromatog. (LC) method was developed using acetonitrile and water for the determination of diospyrin, a pharmacol. important bisnaphthoquinonoid plant-product. The method was validated for precision, accuracy and reproducibility, and was found to be linear over the concentration range of 1-1000 μg/mL; the limits of detection and quantitation were 8 and 20 ng, resp. The technique was used to determine the amount of diospyrin in plant extracts from four climatic regions in India. It was also applied for differentiation and separation of 27 naphthyl compounds While a composition of 50:50 was preferable for dimeric compounds, the composition 40:60 was a better choice for the monomers. Also, the isomeric α- and β-naphthols and their dimers could be distinguished by conversion into the resp. Me ethers.

Journal of Chromatography A published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, SDS of cas: 2960-93-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Lemasson, Fabien published the artcilePolymer Library Comprising Fluorene and Carbazole Homo- and Copolymers for Selective Single-Walled Carbon Nanotubes Extraction, Application In Synthesis of 152873-79-5, the publication is Macromolecules (Washington, DC, United States) (2012), 45(2), 713-722, database is CAplus.

To date, (n, m) single-walled carbon nanotubes (SWNTs) cannot be selectively synthesized. Therefore, postprocessing of SWNTs including solubilization and sorting is necessary for further applications. Toward this goal, we have synthesized a polymer library consisting of fluorene- and carbazole-based homo- and copolymers. Variations of the connection of these aromatics together with the incorporation of further conjugated monomers give access to a broad diversity of polymers. Their ability to selectively wrap specific (n, m) species is investigated toward HiPco SWNTs raw material which contains more than 40 (n, m) species. Absorption and fluorescence spectroscopies were used to analyze SWNTs/polymer suspensions. These results provide evidence for selective SWNTs/polymer interactions and allow a more detailed assessment of polymer structure-property relationships, thus paving the way toward custom synthesis of polymers for single (n, m) SWNTs extraction

Macromolecules (Washington, DC, United States) published new progress about 152873-79-5. 152873-79-5 belongs to naphthyridine, auxiliary class Trifluoromethyl,Sulfonate,Benzene, name is 1,5-NAphthalenebis(trifluoromethanesulfonate), and the molecular formula is C12H6F6O6S2, Application In Synthesis of 152873-79-5.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Guesmi, Ahlem published the artcileStudy of the colorimetric and photoluminescence properties of polyamide fiber, Recommanded Product: 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, the publication is Oriental Journal of Chemistry (2017), 33(5), 2311-2317, database is CAplus.

This research work involves the synthesis, the characterization, and the dyeing application of some reactive dyes on the polyamide fibers. All the dyeing parameters have been studied, pH 4 was registered as the optimal pH value of dyeing polyamide fabrics with the synthesized dyes. The color depth as measured by the K/S value, the colorfastness to washing and light were also evaluated. Under UV exposure, intense emission of orange red was observed for dyed polyamide. Potential applications of this technol. include protective clothing, textile-based sensors, and smart tagging.

Oriental Journal of Chemistry published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Recommanded Product: 4-Amino-3-hydroxynaphthalene-1-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Haque, T. M. A. published the artcileSynthesis, characterization and antibacterial activity of Zn(II) and Cd(II) Schiff base complexes with monovalent bidentate ligand, COA of Formula: C10H9NO4S, the publication is Asian Journal of Biochemical and Pharmaceutical Research (2016), 6(2), 63-70, database is CAplus.

A new Schiff base, N (4-dimethylamino benzylidene) amino-2-naphthol-4-sulfonic acid has been synthesized from 4-dimethylamino benzaldehyde and 1-amino-2-naphthol-4-sulfonic acid. Zn (II) and Cd(II) complexes of the above ligand was synthesized as well. The chem. structures of the Schiff-base ligand and its metal complexes were confirmed by IR, UV-VIS, 1H NMR, elemental anal., molar conductance and m.p. The anal. data of the complexes show the formation of 1:2 metal to ligand ratio with the formula [ML2], where M represents Zn(II) and Cd(II) ions, and L represents the Schiff base ligand resp., diamagnetic nature and a tetrahedral geometry around the metal ion. The results suggest that the Schiff base is a monovalent anion with bidentate ON donor atoms of the phenolic oxygen and the azomethine nitrogen atoms. The complexes were non-electrolytes in DMSO solvent (DMSO). Antibacterial activity of prepared Schiff′s base and its metal complexes were studied on gram pos. Staphylococcus aureus and gram neg. Escherichia coli. It was found that the Schiff′s bases under study were considered inhibitors for bacterial growth with variation extent.

Asian Journal of Biochemical and Pharmaceutical Research published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, COA of Formula: C10H9NO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Zou, Wei published the artcileSulindac metabolism and synergy with tumor necrosis factor-α in a drug-inflammation interaction model of idiosyncratic liver injury, COA of Formula: C20H17FO4S, the publication is Journal of Pharmacology and Experimental Therapeutics (2009), 331(1), 114-121, database is CAplus and MEDLINE.

Sulindac (SLD) is a nonsteroidal anti-inflammatory drug (NSAID) that has been associated with a greater incidence of idiosyncratic hepatotoxicity in human patients than other NSAIDs. In previous studies, cotreatment of rats with SLD and a modestly inflammatory dose of lipopolysaccharide (LPS) led to liver injury, whereas neither SLD nor LPS alone caused liver damage. In studies presented here, further investigation of this animal model revealed that the concentration of tumor necrosis factor-α (TNF-α) in plasma was significantly increased by LPS at 1 h, and SLD enhanced this response. Etanercept, a soluble TNF-α receptor, reduced SLD/LPS-induced liver injury, suggesting a role for TNF-α. SLD metabolites in plasma and liver were determined by LC/MS/MS. Cotreatment with LPS did not increase the concentrations of SLD or its metabolites, excluding the possibility that LPS contributed to liver injury through enhanced exposure to SLD or its metabolites. The cytotoxicities of SLD and its sulfide and sulfone metabolites were compared in primary rat hepatocytes and HepG2 cells; SLD sulfide was more toxic in both types of cells than SLD or SLD sulfone. TNF-α augmented the cytotoxicity of SLD sulfide in primary hepatocytes and HepG2 cells. These results suggest that TNF-α can enhance SLD sulfide-induced hepatotoxicity, thereby contributing to liver injury in SLD/LPS-cotreated rats.

Journal of Pharmacology and Experimental Therapeutics published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C5H5NO3S, COA of Formula: C20H17FO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Viglianisi, Caterina published the artcileRegioselective Electrophilic Access to Naphtho[1,2-b:8,7-b’]- and -[1,2-b:5,6-b’]dithiophenes, COA of Formula: C12H6F6O6S2, the publication is Journal of Organic Chemistry (2013), 78(7), 3496-3502, database is CAplus and MEDLINE.

A two-step one purification access to dichloronaphtho[1,2-b:8,7-b’] and [1,2-b:5,6-b’]dithiophenes, e.g. I and II, using bis-alkylnaphthyl alkynes and phthalimidesulfenyl chloride as starting materials has been developed. The functionalization of the carbon-chlorine bonds allowed further modification of NDT core, broadening the potential of the methodol.

Journal of Organic Chemistry published new progress about 152873-79-5. 152873-79-5 belongs to naphthyridine, auxiliary class Trifluoromethyl,Sulfonate,Benzene, name is 1,5-NAphthalenebis(trifluoromethanesulfonate), and the molecular formula is C8H4ClF3O, COA of Formula: C12H6F6O6S2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Wang, Wei-Lin published the artcileAldehyde dehydrogenase 2 family member (ALDH2) is a therapeutic index for oxaliplatin response on colorectal cancer therapy with dysfunction p53, Category: naphthyridine, the publication is BioMed Research International (2022), 1322788, database is CAplus and MEDLINE.

Oxaliplatin resistance is a major issue in the treatment of p53 mutant colorectal cancer (CRC). Finding the specific biomarkers would improve therapeutic efficacy of patients with CRC. In order to figure out the biomarker for CRC patients with mutant p53 access oxaliplatin, a Gene Expression Omnibus dataset (GSE42387) was used to determine differentially expressed genes (DEGs). The Search Tool for the Retrieval of Interacting Genes (STRING) and Cytoscape software were used to predict protein-protein interactions. The Database for Annotation, Visualization, and Integrated Discovery online tool was used to group the DEGs into their common pathways. A 138 DEGs were identified with 46 upregulated and 92 downregulated. In the PPI networks, 7 of the upregulated genes and 13 of the downregulated genes were identified as hub genes (high degrees). Four hub genes, aldehyde dehydrogenase 2 family member (ALDH2), aldo-keto reductase family 1 member B1 (AKR1B1), aldo-keto reductase family 1 member B10 (AKR1B10), and monoglyceride lipase (MGLL) were enriched in the most significant pathway, glycerolipid metabolism Further, we found that low expression of ALDH2 is correlated with poor overall survival and oxaliplatin resistance. Finally, we found that combined treatment with ALDH2 inhibitor and oxaliplatin will reduce the sensitivity to oxaliplatin in p53 mutant HT29 cells. In conclusion, we demonstrate that ALDH2 may be a biomarker for oxaliplatin resistance status in CRC patients and bring new insight into treatment strategy for p53 mutant CRC patients.

BioMed Research International published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C6H6N2O, Category: naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Ciolino, Henry P. published the artcileSulindac and its metabolites induce carcinogen metabolizing enzymes in human colon cancer cells, Recommanded Product: Sulindac sulfone, the publication is International Journal of Cancer (2008), 122(5), 990-998, database is CAplus and MEDLINE.

Sulindac is a nonsteroidal antiinflammatory drug that has been demonstrated to be a potent chemopreventive agent against colorectal cancer in both human and animal models. In vivo, sulindac may be reversibly reduced to the active antiinflammatory compound, sulindac sulfide, or irreversibly oxidized to sulindac sulfone. Sulindac has also been shown to inhibit polycyclic aromatic hydrocarbon (PAH)-induced cancer, but the mol. mechanisms of its antitumor effect remain unclear. In this study, we investigated the effects of sulindac and its metabolites on the expression of enzymes that metabolize and detoxify PAHs in 2 human colon cancer cell lines, LS180 and Caco-2. Sulindac and sulindac sulfide induced a sustained, concentration-dependent increase in CYP enzyme activity as well as an increase in the mRNA levels of CYP1A1, CYP1A2 and CYP1B1. Sulindac and sulindac sulfide induced the transcription of the CYP1A1 gene, as measured by the level of heterogeneous nuclear CYP1A1 RNA and verified by the use of actinomycin D as a transcription inhibitor. Chromatin immunoprecipitation assays demonstrated that sulindac and sulindac sulfide also increased the nuclear level of activated aryl hydrocarbon receptor, the transcription factor which mediates CYP expression. Addnl., sulindac and both metabolites increased the activity and mRNA expression of the carcinogen detoxification enzyme NAD(P)H:quinone oxidoreductase, as well as the expression of UDP-glucuronosyltransferase mRNA. These results show an overall upregulation of carcinogen metabolizing enzymes in colon cancer cells treated with sulindac, sulindac sulfide and sulindac sulfone that may contribute to the established chemoprotective effects of these compounds

International Journal of Cancer published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Recommanded Product: Sulindac sulfone.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Silveira, Eva Lucia Cardoso published the artcileMolecular absorption spectrophotometric method for the determination of phosphorus in biodiesel, Synthetic Route of 116-63-2, the publication is Fuel (2011), 90(11), 3485-3488, database is CAplus.

A mol. absorption method is proposed for the determination of phosphorus in biodiesel. The samples are mineralized using an ashing procedure at 550° followed by dissolution of the residue. The anal. procedure is based on the formation of a blue molybdenum complex with phosphoric acid when 1-amino-2-naphthol-4-sulfonic acid was used as reducing agent. The method was applied to biodiesel samples prepared from soy, canola and sunflower oils and from bovine fat. The limit of detection is 0.57 mg/P/kg^-1 and the limit of quantification is 1.7 mg/P/kg^-1. The observed mean relative standard deviation is about 5%. The simplicity of the procedure added to its precision, accuracy and low cost suggest that it is an excellent option for the determination of phosphorus in biodiesel.

Fuel published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H16Br3N, Synthetic Route of 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem