Month: November 2022

Prade, Elke published the artcileSulindac Sulfide Induces the Formation of Large Oligomeric Aggregates of the Alzheimer’s Disease Amyloid-β Peptide Which Exhibit Reduced Neurotoxicity, Application of Sulindac sulfone, the publication is Biochemistry (2016), 55(12), 1839-1849, database is CAplus and MEDLINE.

Alzheimer’s disease is characterized by deposition of the amyloid β-peptide (Aβ) in brain tissue of affected individuals. In recent years, many potential lead structures have been suggested that can potentially be used for diagnosis and therapy. However, the mode of action of these compounds is so far not understood. Among these small mols., the nonsteroidal anti-inflammatory drug (NSAID) sulindac sulfide received a lot of attention. In this manuscript, we characterize the interaction between the monomeric Aβ peptide and the NSAID sulindac sulfide. We find that sulindac sulfide efficiently depletes the pool of toxic oligomers by enhancing the rate of fibril formation. In vitro, sulindac sulfide forms colloidal particles which catalyze the formation of fibrils. Aggregation is immediate, presumably by perturbing the supersaturated Aβ solution We find that sulindac sulfide induced Aβ aggregates are structurally homogeneous. The C-terminal part of the peptide adopts a β-sheet structure, whereas the N-terminus is disordered. The salt bridge between D23 and K28 is present, similar as in wild type fibril structures. ¹³C-¹⁹F transferred echo double resonance experiments suggest that sulindac sulfide colocalizes with the Aβ peptide in the aggregate.

Biochemistry published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Application of Sulindac sulfone.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Solntsev, Kyril M. published the artcileExcited-state proton transfer in chiral environments: photoracemization of BINOLs, Recommanded Product: 2,2′-Dimethoxy-1,1′-binaphthalene, the publication is Israel Journal of Chemistry (2009), 49(2), 227-233, database is CAplus and MEDLINE.

We have studied excited-state proton transfer (ESPT) from chiral proton donors to chiral and achiral acceptors. The key role of the exergonicity of the reaction and the transition-state position along the reaction coordinate for the existence of an enantiomeric effect was established. This effect was observed for “super” photoacids (ΔG << 0) and vanished for endergonic reactions (ΔG > 0) where a “late” transition state similar to planar achiral binaphtholate anion occurs. As a result, photoracemization was observed, as confirmed by CD spectroscopy. The photoracemization effects were studied for several chiral photoacids (BINOLs and their ethers) and proton acceptors (amines, aminoalcs., and water) using UV-vis, steady-state fluorescence, and time-resolved fluorescence spectroscopies. The nature of the solvent and the proton acceptor, as well as the chem. structure of the BINOL, played a pivotal role in the photochem. reactivity of the system. Two proposed pathways competed for photoracemization: excited-state inter- and intra-mol. proton transfer, the former being more effective. Irradiation of the dimethoxy BINOL derivative, which lacks an acidic proton and cannot undergo ESPT, produced no appreciable reaction or racemization.

Israel Journal of Chemistry published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C17H20ClN3, Recommanded Product: 2,2′-Dimethoxy-1,1′-binaphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Fourches, Denis published the artcileCheminformatics Analysis of Assertions Mined from Literature that Describe Drug-Induced Liver Injury in Different Species, Recommanded Product: Sulindac sulfone, the publication is Chemical Research in Toxicology (2010), 23(1), 171-183, database is CAplus and MEDLINE.

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chem. structures is critical to help guide exptl. drug discovery projects toward safer medicines. In this study, the authors have compiled a data set of 951 compounds reported to produce a wide range of effects in the liver in different species, comprising humans, rodents, and nonrodents. The liver effects for this data set were obtained as assertional metadata, generated from MEDLINE abstracts using a unique combination of lexical and linguistic methods and ontol. rules. The authors have analyzed this data set using conventional cheminformatics approaches and addressed several questions pertaining to cross-species concordance of liver effects, chem. determinants of liver effects in humans, and the prediction of whether a given compound is likely to cause a liver effect in humans. The authors found that the concordance of liver effects was relatively low (âˆ?9-44%) between different species, raising the possibility that species specificity could depend on specific features of chem. structure. Compounds were clustered by their chem. similarity, and similar compounds were examined for the expected similarity of their species-dependent liver effect profiles. In most cases, similar profiles were observed for members of the same cluster, but some compounds appeared as outliers. The outliers were the subject of focused assertion regeneration from MEDLINE as well as other data sources. In some cases, addnl. biol. assertions were identified, which were in line with expectations based on compounds’ chem. similarities. The assertions were further converted to binary annotations of underlying chems. (i.e., liver effect vs. no liver effect), and binary quant. structure-activity relationship (QSAR) models were generated to predict whether a compound would be expected to produce liver effects in humans. Despite the apparent heterogeneity of data, models have shown good predictive power assessed by external 5-fold cross-validation procedures. The external predictive power of binary QSAR models was further confirmed by their application to compounds that were retrieved or studied after the model was developed. To the best of the authors’ knowledge, this is the first study for chem. toxicity prediction that applied QSAR modeling and other cheminformatics techniques to observational data generated by the means of automated text mining with limited manual curation, opening up new opportunities for generating and modeling chem. toxicol. data.

Chemical Research in Toxicology published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Recommanded Product: Sulindac sulfone.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Fogli, Stefano published the artcileTherapeutic potential of sulindac hydroxamic acid against human pancreatic and colonic cancer cells, Name: Sulindac sulfone, the publication is European Journal of Medicinal Chemistry (2010), 45(11), 5100-5107, database is CAplus and MEDLINE.

The non-steroidal anti-inflammatory drug (NSAID) sulindac exhibits cyclooxygenase (COX)-dependent and COX-independent chemopreventive properties in human cancer. The present study was aimed at investigating whether the hydroxamic acid substitution for the carboxylic acid group could enhance the in vitro antitumor and antiangiogenic activities of sulindac. Characterization tools used on this study included analyses of cell viability, caspase 3/7 induction, DNA fragmentation, and gene expression. Our findings demonstrate that the newly synthesized hydroxamic acid derivative of sulindac and its sulfone and sulfide metabolites were characterized by a good anticancer activity on human pancreatic and colon cancer cells, both in terms of potency (IC₅₀ mean values from 6 ± 1.1 μM to 64 ± 1.1 μM) and efficacy (E _max of âˆ?00%). Hydroxamic acid derivatives trigger a higher degree of apoptosis than carboxylic acid counterparts, increase bax/bcl-2 expression ratio and induce caspase 3/7 activation. Most notably, these compounds significantly inhibit proangiogenic growth factor-stimulated proliferation of vascular endothelial cell (HUVEC) at sub-micromolar concentrations Our data also provide evidence that the COX-active metabolite of sulindac hydroxamic acid were the most active of the series and selective inhibition of COX-1 but not COX-2 can mimic its effects, suggesting that COX inhibition could only play a partial role in the mechanism of compound action. In conclusion, these data demonstrate that substitution of the carboxylic acid group with the hydroxamic acid moiety enhances in vitro antiproliferative, proapoptotic and antiangiogenic properties of sulindac, therefore increasing the therapeutic potential of this drug.

European Journal of Medicinal Chemistry published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Name: Sulindac sulfone.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Yousef, L. A. published the artcileUranium(VI) Adsorption Using a Mixture of 1-Amino-2-naphthol-4-sulfonic Acid and Bentonite: Kinetic and Equilibrium Studies, Quality Control of 116-63-2, the publication is Radiochemistry (Moscow, Russian Federation) (2020), 62(4), 511-523, database is CAplus.

Abstract: Uranium was adsorbed using bentonite treated with 1-amino-2-naphthol-4-sulfonic acid (ANSA). The prepared Bt-(ANSA) was characterized, and its adsorption affinity for uranium(VI) was evaluated. The influence exerted on the uranium adsorption by pH, contact time, adsorbent dose, initial uranium concentration, interfering ions, and temperature was studied. The optimum conditions are pH 8.5, 0.04 g of Bt-(ANSA) per 10 mL of 400 mg/L uranium solution, and 20-min contact at room temperature The majority of cations except Th, Fe, Cu, and Ni do not interfere with the uranium adsorption. The adsorption kinetics and equilibrium were studied. The application of the Langmuir model showed that the maximum sorption capacity reached 90.9 mg/g at room temperature The adsorption process was found to follow a pseudo-second order kinetic model at 400 mg/L uranium concentration Evaluation of thermodn. parameters (ΔG°, ΔH°, and ΔS°) shows that the adsorption is spontaneous exothermic accompanied by a decrease in randomness. Uranium(VI) ions were efficiently desorbed using a 1 M HNO3 solution with the adsorbent regeneration. The optimum conditions were applied to sep. uranium from carbonate leach liquor solution of a field sample from Abu Hamatta area, SW Sinai, Egypt.

Radiochemistry (Moscow, Russian Federation) published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C9H9ClN2, Quality Control of 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Lee, Taegweon published the artcileStereoselective Hydroboration of Diynes and Triyne to Give Products Containing Multiple Vinylene Bridges: A Versatile Application to Fluorescent Dyes and Light-Emitting Copolymers, Safety of 9,10-Diethynylanthracene, the publication is Organometallics (2004), 23(20), 4569-4575, database is CAplus.

The Rh(I)-catalyzed hydroboration of a variety of aromatic diynes and a triyne afforded bis(boryl)- and tris(boryl)vinyl products. The hydroboration products underwent Suzuki cross-coupling reactions with a variety of substrates containing chromophore units to give fluorescent dye-substituted products. The hydroboration product also reacted with dibromoarenes to afford an oligomer with a vinylene unit along the oligomer backbone.

Organometallics published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Safety of 9,10-Diethynylanthracene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Tazerouti, Fairouz published the artcileAnalysis of the mechanism of retention on a modified β-cyclodextrin/silica chiral stationary phase using a computational chemical method, HPLC of Formula: 2960-93-2, the publication is Journal of Liquid Chromatography & Related Technologies (2007), 30(20), 3043-3057, database is CAplus.

Quant. anal. of the retention of various optically active solutes on a modified β-cyclodextrin/silica chiral stationary phase was achieved using a mol. mechanics calculation of the CAChe program. Using computational chem. calculations, the various interactions between each enantiomer and the modified β-cyclodextrin chiral selector were calculated as energy contributions. These interaction energy values were then compared to the exptl. values measured in normal phase liquid chromatog. Among the obtained predicted values, the best correlation was observed between the mol. interaction energy and the selectivity factor, α, calculated for the studied racemates.

Journal of Liquid Chromatography & Related Technologies published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C20H19NO4, HPLC of Formula: 2960-93-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Ikai, Tomoyuki published the artcileChiral stationary phases consisting of π-conjugated polymers bearing glucose-linked biphenyl units: reversible switching of resolution abilities based on a coil-to-helix transition, SDS of cas: 2960-93-2, the publication is Polymer Chemistry (2017), 8(29), 4190-4198, database is CAplus.

A series of optically active π-conjugated polymers (poly-2-poly-5) consisting of alternating thieno[3,4-b]thiophene and glucose-linked biphenyl units were synthesized through copolymerizations by Sonogashira-Hagihara cross-coupling. Absorption and CD spectroscopy and theor. calculations revealed that poly-2 undergoes a conformational transition between the random-coil and helix in both solution and the solid state in response to the external solvent environment (chloroform and acetonitrile). Coated-type chiral stationary phases (CSPs) for high-performance liquid chromatog. were prepared from both the random-coil and helical poly-2, and the influence of the polymer backbone structure on the chiral recognition ability was evaluated. The two CSPs showed somewhat complementary resolution abilities and the kinds of resolved racemates were dependent on the backbone conformation. In addition, an immobilized-type CSP with universal solvent durability was also prepared through copper-catalyzed click cyclization between an alkyne-appended poly-2 analog and an azide-functionalized silica gel. The resulting CSP displayed repeatable switching of the chiral recognition ability based on a coil-to-helix transition of the polymer backbone by alternate column treatment with common organic solvents, such as chloroform and acetonitrile.

Polymer Chemistry published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, SDS of cas: 2960-93-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Gado, Mohamed A. published the artcileThorium ions adsorption from aqueous solution by amino naphthol sulphonate coupled chitosan, Quality Control of 116-63-2, the publication is International Journal of Environmental Analytical Chemistry (2021), 101(10), 1419-1436, database is CAplus.

A designed new adsorbent by coupling chitosan and 1-Amino-2-naphthol-4-sulfonic acid to get an excellent synergistic effect of 1-Amino-2-naphthol-4-sulfonic coupled chitosan (ANSC) which used for the removal of tetravalent thorium ions. The modified chitosan adsorbent was identified by BET isotherm studies, elemental anal., SEM, EDX and FT-IR, techniques. The FT-IR confirmed the structure of the modified chitosan. Langmuir isotherm model described the adsorption results with the 252.57 mg/g maximum adsorption capacity. It should be perceived that the thorium ions adsorption matched more careful with the kinetics pseudo-second-order. It was found that the adsorption of Th(IV) is strongly dependent on pH and time.

International Journal of Environmental Analytical Chemistry published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Quality Control of 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Gado, Mohamed published the artcileThe role of graphene oxide anchored 1-amino-2-naphthol-4-sulphonic acid on the adsorption of uranyl ions from aqueous solution: kinetic and thermodynamic features, Application of 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, the publication is International Journal of Environmental Analytical Chemistry (2019), 99(10), 996-1015, database is CAplus.

Graphene oxide-1-amino-2-naphthol-4-sulfonic acid (GOANS) adsorbent synthesized successfully from a natural source (cattle bones) for the U(VI) ions removal from liquid waste solutions The synthesized adsorbent characterized via Fourier transform IR (FTIR) spectroscopy, Brunauer-Emmett-Teller (BET) surface area anal., energy-dispersive x-ray spectroscopy (EDX) pattern, and SEM. Various exptl. parameters (time, adsorbent weight, initial uranium concentration and temperature) investigated and the results reveal that a higher uptake capacity of 311.5 mg/g achieved at pH 4 within 60 min. The obtained findings fitted well with thermodn., isothermal (Langmuir and Freundlich model) and pseudo second order kinetics. The neg. sign of (ΔG°)specified the spontaneity of adsorption process in the thermodn. study, (ΔH°) and pos. sign (ΔS°) indicate high randomness after adsorption.

International Journal of Environmental Analytical Chemistry published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Application of 4-Amino-3-hydroxynaphthalene-1-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem