Month: November 2022

Haggam, Reda Ahmed published the artcileA series of 1,3-imidazoles and triazole-3-thiones based thiophene-2-carboxamides as anticancer agents: Synthesis and anticancer activity, Recommanded Product: 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, the publication is European Journal of Chemistry (2018), 9(2), 99-106, database is CAplus.

By addition of semicarbazide or phenylhydrazine hydrochloride to thienoylisothiocyanate resulted in building of thiosemicarbazide derivative , triazole derivative and thiophene-2-carboxamide, resp. Basic cyclization of thiosemicarbazide derivative led to formation of oxadiazine. Synthesis of thiadiazine derivative was achieved via reaction of thiophene-2-carboxamide and maleic anhydride in tri-Et amine. Heating of thiophene-2-carboxamide with Et chloroacetate or sodium ethoxide produced thiadiazine derivative and triazolethione, resp. Thiosemicarbazide derivative was synthesized by addition of nicotinic hydrazide to thienoylisothiocyanate. Refluxing of Thiosemicarbazide derivative with lead acetate afforded triazole. Moreover, acid and base mediated cyclizations of thiosemicarbazide derivative gave thiadiazole and 1,2,4-triazolethione throughout thiophene intermediate, resp. Addition of Et 2-aminothiophene-3-carboxylate to thienoylisothiocyanate formed thiourea which was refluxed with ethoxide giving thiophene-3-carboxylic acid. Lastly, nucleophilic addition of amino phenol or ethylene diamine to thienoylisothiocyanate yielded oxazine structure and imidazole derivative, resp. The yields of the synthesized compounds were 61-95%. The detailed synthesis and spectroscopic data of the new compounds were reported.

European Journal of Chemistry published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Recommanded Product: 4-Amino-3-hydroxynaphthalene-1-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Busse, Madleen published the artcileSynthesis and Structure of Silver Amino-Arenesulfonates, Product Details of C10H9NO4S, the publication is European Journal of Inorganic Chemistry (2012), 2012(7), 1061-1071, database is CAplus.

Treatment of a variety of zwitterionic amino-arenesulfonic acids with Ag oxide gave seven new Ag^I amino-arenesulfonates [Ag(O₃SR)]_{âˆ?/sub> [R = o-aminobenzyl (oAB) (1), m-aminobenzyl (mAB) (2), 6-amino-3-methoxybenzyl (6A3MB) (3), o-aminonaphthyl (oAN) (4), 5-aminonaphthyl (5AN) (5), 4-amino-3-hydroxynaphthyl (4A3HN) (6) and 5-isoquinolinyl (I) (7)]. This has allowed an exploration of their coordination chem., whereby the authors examine the impact of structural diversity in the anions: the position of the amino functionality on the arene moiety, inclusion of the N within a heterocycle and an increase in ring size from Ph to naphthyl. The solid-state structures of 1, 2 and two forms of 4, one with a coordinated H2O mol., were determined by x-ray diffraction and are all polymeric. Anal. data is provided for two of the structurally known complexes: known Ag p-aminobenzenesulfonate (8) [Ag(O3SBAp)]âˆ?/sub> and Ag^I 2-pyridinesulfonate [Ag(O3SP)]âˆ?/sub> (9). The composition of all nine complexes was confirmed through NMR spectroscopy, MS-ES⁺, FTIR and elemental anal.}

European Journal of Inorganic Chemistry published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Product Details of C10H9NO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Abd-Alredha, L. published the artcileSynthesis and characterization of azo dye para red and new derivatives, Application In Synthesis of 116-63-2, the publication is Journal of Chemistry (2012), 9(1), 465-470, database is CAplus.

Azo dyes were synthesized. The products were characterized by FTIR and UV-visible spectrophotometers. The antibacterial activities of the compounds were studied using gram pos. and gram neg. microorganism.

Journal of Chemistry published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Application In Synthesis of 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Khan, Muhammad S. published the artcileSynthesis, characterization and optical spectroscopy of platinum(II) di-ynes and poly-ynes incorporating condensed aromatic spacers in the backbone, Synthetic Route of 18512-55-5, the publication is Dalton Transactions (2004), 2377-2385, database is CAplus and MEDLINE.

Protected and terminal dialkynes with extended π-conjugation through a condensed aromatic linker unit in the backbone, 1,4-bis(trimethylsilylethynyl)naphthalene, 2a, 1,4-bis(ethynyl)naphthalene, 2b, 9,10-bis(trimethylsilylethynyl)anthracene 3a, 9,10-bis(ethynyl)anthracene 3b, were synthesized and characterized spectroscopically. The solid-state structures of 2a and 3a were confirmed by single crystal x-ray diffraction studies. Reaction of two equivalent of trans-[Ph(Et₃P)₂PtCl] with an equivalent of the terminal dialkynes 1,4-bis(ethynyl)benzene 1b and 2b–3b, in ⁱPr₂NH-CH₂Cl₂, in the presence of CuI, at room temperature, afforded the Pt(II) di-ynes trans-[Ph(Et₃P)₂Pt-CC-R-CC-Pt(PEt₃)₂Ph] (R = benzene-1,4-diyl 1c; naphthalene-1,4-diyl 2c and anthracene-9,10-diyl 3c) while reactions between equimolar quantities of trans-[(Bu₃P)₂PtCl₂] and 2b–3b under similar conditions readily afforded the Pt(II) poly-ynes trans-[-(Bu₃P)₂Pt-CC-R-CC-]_n (R = naphthalene-1,4-diyl 2d and anthracene-9,10-diyl 3d). The Pt(II) diynes and poly-ynes were characterized by anal. and spectroscopic methods, and the single crystal x-ray structures of 1c and 2c were determined These structures confirm the trans-square planar geometry at the Pt centers and the linear nature of the mols. The di-ynes and poly-ynes are soluble in organic solvents and readily cast into thin films. Optical spectroscopic measurements reveal that the electron-rich naphthalene and anthracene spacers create strong donor-acceptor interactions between the Pt(II) centers and conjugated ligands along the rigid backbone of the organometallic polymers. TG shows that the di-ynes possess a somewhat higher thermal stability than the corresponding poly-ynes. Both the Pt(II) di-ynes and the poly-ynes exhibit increasing thermal stability along spacers from phenylene through naphthalene to anthracene.

Dalton Transactions published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Synthetic Route of 18512-55-5.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Grisorio, Roberto published the artcileMonodispersed vs. polydispersed systems for bulk heterojunction solar cells: the case of dithienopyrrole/anthracene based materials, Recommanded Product: 9,10-Diethynylanthracene, the publication is Journal of Materials Chemistry (2012), 22(37), 19752-19760, database is CAplus.

The article reports on the properties of a new class of arylene-ethynylene semiconductors incorporating anthracene and the bridged bithiophene dithienopyrrole. Two monodispersed structures were synthesized: the first with a dithienopyrrole core bound to two anthracenyl-ethynyl side groups namely the 2,6-bis(anthracen-9-ylethynyl)-4-(2-ethylhexyl)-4H-dithieno[3,2-b:2′,3′-d]pyrrole (ADA); in the second structure the anthracene core was functionalized with two dithienopyrrolylethynyl groups, obtaining 9,10-bis((4-(2-ethylhexyl)-4H-dithieno[3,2-b:2′,3′-d]pyrrol-2-yl)ethynyl)anthracene (DAD). The properties of these materials were compared with those of the corresponding polymer poly[4-(2-ethylhexyl)-4H-dithieno[3,2-b:2′,3′-d]pyrrole-2,6-diylethynylene-anthracen-9,10-diylethynylene] (polyAD). Devices employing PC₆₁BM as an electron acceptor revealed that the monodispersed materials (ADA and DAD) were better performing than polyAD, seemingly due to the better homogeneity of the donor-acceptor blend, as revealed by at. force microscopy. The power conversion efficiency value (1.3%) obtained with DAD ranks among the highest reported for non-polymeric small mol.-based bulk heterojunction solar cells constructed without the use of additives or annealing processes, thus demonstrating that ethynylene-containing electron-rich systems are promising donors for organic solar cell applications.

Journal of Materials Chemistry published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Recommanded Product: 9,10-Diethynylanthracene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Sankaran, Balasubramanian published the artcileSynthesis, emission and spectro-electrochemical studies of bithienylnaphthalene systems, Application of 1,5-NAphthalenebis(trifluoromethanesulfonate), the publication is Synthetic Metals (2001), 123(3), 425-433, database is CAplus.

Four bis(2-thienyl)naphthalene monomers were synthesized and their absorption, emission and redox properties were studied. The monomers 1,5-dimethoxy-2,6-bis(2-thienyl)naphthalene (2,6-BTDMN), 1,5-dimethoxy-4,8-bis(2-thienyl)-naphthalene (4,8-BTDMN), and 1,4,5,8-tetramethoxy-2,6-bis(2-thienyl)naphthalene (2,6-BTTMN) were synthesized by Stille coupling reaction between the resp. dibromides and 2-(tributylstannyl)-thiophene. The monomers 2,6-bis(2-thienyl)-naphthalene (2,6-BTN, previously prepared from dibromo precursor) and 1,5-bis(2-thienyl)-naphthalene (1,5-BTN) were prepared similarly between the corresponding di-triflates and 2-(tributylstannyl)thiophene. Monomers 1,5-BTN and 4,8-BTDMN have only one peak in both absorption and emission spectra, while monomers 2,6-BTN, 2,6-BTDMN, and 2,6-BTTMN show multiple bands for absorption and a single doublet for emission. The oxidation potential is 0.95 V for 1,5-BTN and 0.59 V for monomer 2,6-BTTMN. Electrochem. polymerization of the monomers, with the exception of 2,6-BTTMN which was obtained by oxidative polymerization using FeCl₃ as oxidant, produced good polymeric films on ITO coated glass electrodes. The polythiophenes are pale greenish in color in the oxidized state and relatively transparent and pale yellow in the reduced state. Spectro-optoelelectrochem. studies revealed a band gap of 2.4-2.9 eV. Iodine-doped poly(2,6-BTTMN) has a conductivity of 5×10^-2 S/cm.

Synthetic Metals published new progress about 152873-79-5. 152873-79-5 belongs to naphthyridine, auxiliary class Trifluoromethyl,Sulfonate,Benzene, name is 1,5-NAphthalenebis(trifluoromethanesulfonate), and the molecular formula is C12H6F6O6S2, Application of 1,5-NAphthalenebis(trifluoromethanesulfonate).

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Nadanaciva, Sashi published the artcileToxicity assessments of nonsteroidal anti-inflammatory drugs in isolated mitochondria, rat hepatocytes, and zebrafish show good concordance across chemical classes, Safety of Sulindac sulfone, the publication is Toxicology and Applied Pharmacology (2013), 272(2), 272-280, database is CAplus and MEDLINE.

To reduce costly late-stage compound attrition, there has been an increased focus on assessing compounds in in vitro assays that predict attributes of human safety liabilities, before preclin. in vivo studies are done. Relevant questions when choosing a panel of assays for predicting toxicity are (a) whether there is general concordance in the data among the assays, and (b) whether, in a retrospective anal., the rank order of toxicity of compounds in the assays correlates with the known safety profile of the drugs in humans. The aim of our study was to answer these questions using nonsteroidal anti-inflammatory drugs (NSAIDs) as a test set since NSAIDs are generally associated with gastrointestinal injury, hepatotoxicity, and/or cardiovascular risk, with mitochondrial impairment and endoplasmic reticulum stress being possible contributing factors. Eleven NSAIDs, flufenamic acid, tolfenamic acid, mefenamic acid, diclofenac, meloxicam, sudoxicam, piroxicam, diflunisal, acetylsalicylic acid, nimesulide, and sulindac (and its two metabolites, sulindac sulfide and sulindac sulfone), were tested for their effects on (a) the respiration of rat liver mitochondria, (b) a panel of mechanistic endpoints in rat hepatocytes, and (c) the viability and organ morphol. of zebrafish. We show good concordance for distinguishing among/between NSAID chem. classes in the observations among the three approaches. Furthermore, the assays were complementary and able to correctly identify “toxic” and “non-toxic” drugs in accordance with their human safety profile, with emphasis on hepatic and gastrointestinal safety. We recommend implementing our multi-assay approach in the drug discovery process to reduce compound attrition.

Toxicology and Applied Pharmacology published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Safety of Sulindac sulfone.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Hassan, Hassan M. A. published the artcileValidated spectrophotometric assessment of 1,4-dioxane in drinking water by amionhydroxynaphthlene sulfonic acid (AHSA), Application of 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, the publication is International Journal of Environmental Analytical Chemistry, database is CAplus.

A selective, facile, and highly efficient spectrophotometric approach was established for the determination of 1,4-dioxane in drinking water quant. This approach depends on the reaction selectively of 1,4-dioxane with 1-Amino-2-naphthol-4-sulfonic acid (AHSA) to give an instantly complex measured at 340 nm. The maximum spectra development with high intensity of dioxane-AHSA complex was obtained at 15 min. Variable parameters that affecting the dioxane-AHSA efficacy were estimated and optimized. Under optimal conditions, the dioxane-AHSA complex obeyed Beer′s law within the range of 0.5-15 mg/L of 1,4-dioxane with a regression factor of 0.996 (n = 5) and a detection limit of 16 μg/L. The results of precision and accuracy within-day were ≤2.0% in terms of relative standard deviation (RSD%), which confirmed the reproducibility of the anal. performance. The proposed method was applied successfully in the simultaneous assessment of 1,4-dioxane in an aqueous solution The accuracy and reliability of the developed approach recommended being applied in all quality control of water companies without the use of sophisticated instrumentation and procedure.

International Journal of Environmental Analytical Chemistry published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Application of 4-Amino-3-hydroxynaphthalene-1-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Pangburn, Heather A. published the artcileSulindac metabolites induce proteosomal and lysosomal degradation of the epidermal growth factor receptor, HPLC of Formula: 59973-80-7, the publication is Cancer Prevention Research (2010), 3(4), 560-572, database is CAplus and MEDLINE.

The epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptor tyrosine kinases. In response to ligand, EGFR is internalized and degraded by the ubiquitin-proteasome/lysosome pathway. We previously reported that metabolites of the nonsteroidal anti-inflammatory drug sulindac downregulate the expression of EGFR and inhibit basal and EGF-induced EGFR signaling through extra-cellular signal-regulated kinase 1/2. We now have evaluated the mechanisms of sulindac metabolite-induced downregulation of EGFR. EGF-induced downregulation of EGFR occurs within 10 min and lasts for 24 h. By contrast, downregulation of EGFR by sulindac sulfide and sulindac sulfone was first evident at 4 and 24 h, resp., with maximal downregulation at 72 h. Pretreatment with either the lysosomal inhibitor chloroquine or the proteosomal inhibitor MG132 blocked sulindac metabolite-induced downregulation of EGFR. Sulindac metabolites also increased the ubiquitination of EGFR. Whereas sulindac metabolites inhibited phosphorylation of EGFR pY1068, they increased phosphorylation of EGFR pY1045, the docking site where c-Cbl binds, thereby enabling receptor ubiquitination and degradation Immunofluorescence anal. of EGF and EGFR distribution confirmed the biochem. observations that sulindac metabolites alter EGFR localization and EGFR internalization in a manner similar to that seen with EGF treatment. Expression of ErbB family members HER2 and HER3 was also downregulated by sulindac metabolites. We conclude that downregulation of EGFR expression by sulindac metabolites is mediated via lysosomal and proteosomal degradation that may be due to drug-induced phosphorylation at pY1045 with resultant ubiquitination of EGFR. Thus, sulindac metabolite-induced downregulation of EGFR seems to be mediated through mechanism(s) similar, at least in part, to those involved in EGF-induced downregulation of EGFR.

Cancer Prevention Research published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, HPLC of Formula: 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem