254-60-4, Name is 1,8-Diazanaphthalene, belongs to naphthyridine compound, is a common compound. Computed Properties of C8H6N2In an article, once mentioned the new application about 254-60-4.
As circulating monocytes enter the site of disease, the local microenvironment instructs their differentiation into tissue macrophages (MPhi). To identify mechanisms that regulate MPhi differentiation, we studied human leprosy as a model, since M1-type antimicrobial MPhi predominate in lesions in the self-limited form, whereas M2-type phagocytic MPhi are characteristic of the lesions in the progressive form. Using a heterotypic co-culture model, we found that unstimulated endothelial cells (EC) trigger monocytes to become M2 MPhi. However, biochemical screens identified that IFN-gamma and two families of small molecules activated EC to induce monocytes to differentiate into M1 MPhi. The gene expression profiles induced in these activated EC, when overlapped with the transcriptomes of human leprosy lesions, identified Jagged1 (JAG1) as a potential regulator of MPhi differentiation. JAG1 protein was preferentially expressed in the lesions from the self-limited form of leprosy, and localized to the vascular endothelium. The ability of activated EC to induce M1 MPhi was JAG1-dependent and the addition of JAG1 to quiescent EC facilitated monocyte differentiation into M1 MPhi with antimicrobial activity against M. leprae. Our findings indicate a potential role for the IFN-gamma-JAG1 axis in instructing MPhi differentiation as part of the host defense response at the site of disease in human leprosy.
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Reference£º
1,159-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N153 – PubChem