In an article, author is Song, Geunmoo, once mentioned the application of 38002-45-8, Quality Control of (3-Bromoprop-1-yn-1-yl)trimethylsilane, Name is (3-Bromoprop-1-yn-1-yl)trimethylsilane, molecular formula is C6H11BrSi, molecular weight is 191.141, MDL number is MFCD00134460, category is naphthyridines. Now introduce a scientific discovery about this category.
Aromatic Helical Foldamers as Nucleophilic Catalysts for the Regioselective Acetylation of Octyl beta-d-Glucopyranoside
Two indolocarbazole-naphthyridine foldamers 2 and 3 that fold into helical conformations were prepared. The 4-(N,N-dimethylamino)pyridine (DMAP) moiety was introduced at one end of the foldamer strands to develop foldamer-based catalysts for the site-selective acylation of polyols. These foldamers adopt helical conformations containing internal cavities capable of binding octyl beta-d-glucopyranoside. The association constants were determined to be 1.9 (+/- 0.1)x10(5) M-1 for 2 and 2.1 (+/- 0.1)x10(5) M-1 for 3 in CH2Cl2 at 25 degrees C. In the presence of DMAP, 2 or 3 as the catalysts, octyl beta-d-glucopyranoside was subjected to acetylation under identical reaction conditions. The DMAP-catalysed reaction afforded the random distribution of the monoacetylates (6-OAc : 4-OAc : 3-OAc : 2-OAc=33 : 24 : 41 : 2). In contrast, foldamers 2 and 3 led to the predominant formation of 6-OAc. The relative distributions were estimated to be 6-OAc : 4-OAc : 3-OAc=88 : 4 : 6 : similar to 0 with 2 and 6-OAc : 4-OAc : 3-OAc : 2-OAc=90 : 3 : 6 : 1 with 3.
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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem