5089-22-5, Name is 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene, molecular formula is C24H14N2O2, Recommanded Product: 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene, belongs to naphthyridines compound, is a common compound. In a patnet, author is Defaux, Julien, once mentioned the new application about 5089-22-5.
Discovery of 7-Aryl-Substituted(1,5-Naphthyridin-4-yl) ureas as Aurora Kinase Inhibitors
As part of our research projects to identify new chemical entities of biological interest, we developed a synthetic approach and the biological evaluation of (7-aryl-1,5-naphthyridin-4-yl)ureas as a novel class of Aurora kinase inhibitors for the treatment of malignant diseases based on pathological cell proliferation. 1,5-Naphthyridine derivatives showed excellent inhibitory activities toward Aurora kinases A and B, and the most active compound, 1-cyclopropyl-3-[7-(1-methyl-1H-pyrazol-4-yl)-1,5-naphthyridin-4-yl]urea (49), displayed IC50 values of 13 and 107nM against Aurora kinases A and B, respectively. In addition, the selectivity toward a panel of seven cancer-related protein kinases was highlighted. In vitro ADME properties were also determined in order to rationalize the difficulties in correlating antiproliferative activity with Aurora kinase inhibition. Finally, the good safety profile of these compounds imparts promising potential for their further development as anticancer agents.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 5089-22-5 help many people in the next few years. Recommanded Product: 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem