A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Safety of Trimethoxy(methyl)silane, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1185-55-3, Name is Trimethoxy(methyl)silane, molecular formula is C4H12O3Si. In an article, author is Jia, Xue-Dong,once mentioned of 1185-55-3.
Synthesis and in vitro antitumor activity of novel naphthyridinone derivatives
A series of naphthyridinone derivatives based on 1a (a precursor of Voreloxin) were designed and synthesized. Seven compounds having >70% inhibition against HL60 at 30 mu mol/L were further evaluated for their in vitro antitumor activity by SRB assay. Results reveal that thiazol-2-y1 and 3-aminomethyl-4-benzyloxyimino-3-methylpyrrolidin-1-yl groups are optimal at the N-1 and C-7 positions of naphthyridinone core, respectively. 10j exhibits broad-spectrum activity (IC50: <0.5-6.25 mu mol/L) against all of the tested cell lines including Etoposide- and/or 1a-resistant ones, and is 1.3-fold to >100-fold more potent than the two references against eight Of these cell lines. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem