New research progress on 5959-52-4 in 2021. Reference of 5959-52-4, Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 5959-52-4, Name is 3-Amino-2-naphthoic acid, SMILES is NC1=CC2=C(C=CC=C2)C=C1C(O)=O, belongs to naphthyridine compound. In a article, author is Minakawa, Noriaki, introduce new discover of the category.
Beginning with a simple question, i.e., how is a DNA duplex thermally stabilized if the base pair has four hydrogen bonds, we designed a series of imidazo [5′,4′:4,5] pyrido[2,3-d] pyrimidine (Im) nucleosides and evaluated their base-pairing ability when incorporated into DNA duplexes. All possible Im: Im pairs thermally destabilized the duplexes, although the pair formed four hydrogen bonds between Im units. On the other hand, the resulting duplexes were highly stabilized when three pairs were consecutively incorporated. To stabilize the duplexes independent of the mode of incorporation of the pair(s), we designed a series of 1,8-naphthyridine (Na) C-nucleosides as complementary nucleobases of Im. The newly designed Im: Na base-pairing motifs, especially ImN(N):NaOO, thermally stabilized the duplexes by nearly 10 degrees C more per pair than the A:T and 8 degrees C more than the G: C pair, independent of the mode of incorporation. We describe herein the results concerning the properties of the base-pairing motifs, Im:Im and Im:Na pairs, as well as potential therapeutic application toward a thermally stabilized decoy molecule.
Reference of 5959-52-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 5959-52-4.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem