When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. In an article, author is Wang, Dao-Lin, once mentioned the application of 106-49-0, Name is p-Toluidine, molecular formula is C7H9N. Now introduce a scientific discovery about this category, Safety of p-Toluidine.
An efficient method for the synthesis of novel benzo[b]pyrimido[4′,5′:5,4]thieno[2,3-e]41,61naphthyridine-8-one derivatives via Pictet-Spengler cyclization is reported. The reaction of 4-(3-aminopyrimido[4,5-d]thieno-2-yl)quinoline-2-ones, which could be obtained from Thorpe -Ziegler isomerization of 4-bromomethylquinoline-2-ones and 5-cyano-1,6-dihydro-4-methyl-2-phenyl-6-thioxopyrimidine, with aromatic aldehydes in the presence of BF3.OEt2 gives pyrimidothieno[1,6]naphthyridines in good yields. (C)2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.Welcome to check out more blogs about 106-49-0, in my other articles. Safety of p-Toluidine.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem