The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Derivatives of the ethyl ester of (α-cyanofurylacrylic acid).》. Authors are Lami, Laura; Bartroli, Rita; Diaz, Mercedes; Perera, Eddy.The article about the compound:5-Iodo-2-furaldehydecas:2689-65-8,SMILESS:IC1=CC=C(O1)C=O).Synthetic Route of C5H3IO2. Through the article, more information about this compound (cas:2689-65-8) is conveyed.
Derivatives of Et α-cyanofurylacrylate (I; R = H, NO2, Br, I) were synthesized and tested for fungicidal activity. In vitro against 9 fungi, I (R = NO2) gave >90% inhibition of 5 species (Penicillium italicum, P. digitatum, Phytophthora nicotianae, Helminthosporium oryzae, and Phomopsis citri). As a 0.3% spray, it gave good control of blue mold of tobacco in pot experiments
This literature about this compound(2689-65-8)Synthetic Route of C5H3IO2has given us a lot of inspiration, and I hope that the research on this compound(5-Iodo-2-furaldehyde) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem