So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Brown, Desmond J.; Shinozuka, Kazuo researched the compound: 4-Methyl-6-(methylthio)pyrimidin-2-ol( cas:16710-11-5 ).Product Details of 16710-11-5.They published the article 《Bis-s-triazolo[1,5-a:1′,5′-c]pyrimidine and some simple derivatives》 about this compound( cas:16710-11-5 ) in Australian Journal of Chemistry. Keywords: bistriazolopyrimidine; triazolopyrimidinamine acetoxyaminomethylene preparation cyclization. We’ll tell you more about this compound (cas:16710-11-5).
A general synthetic route to the new tricyclic system bis-s-triazolo[1,5-a:1′,5′-c]pyrimidine is reported. Thus the parent heterocycle (I; R = R1 = H) is prepared from the key bicyclic intermediate, s-triazolo[18k-c]pyrimidin-5-ylamine, through the 5-dimethylaminomethyleneamino, 5-hydroxyaminomethyleneamino and 5-acetoxyaminomethyleneamino derivatives, followed by final cyclization. I (R = H, Me, R1 = H, Me, Ph) are prepared similarly. Structures are confirmed by NMR spectra.
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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem