Jhanwar-Uniyal, Meena; Dominguez, Jose F.; Mohan, Avinash L.; Tobias, Michael E.; Gandhi, Chirag D. published the artcile< Disentangling the signaling pathways of mTOR complexes, mTORC1 and mTORC2, as a therapeutic target in glioblastoma>, SDS of cas: 1223001-51-1, the main research area is glioblastoma therapeutic target disentangling signaling mTORC1 mTORC2; Glioblastoma; mTOR; mTORC1 mTORC2.
Aberrant signaling of mechanistic target of rapamycin (mTOR′ aka mammalian target of rapamycin) is shown to be linked to tumorigenesis of numerous malignancies including glioblastoma (GB). Glioblastoma mTOR is a serine threonine kinase that functions by forming two multiprotein complexes. There complexes are named mTORC1 and mTORC2 and downstream activated substrate execute cellular and metabolic functions. This signaling cascade of PI3K/AKT/mTOR is often upregulated due to frequent loss of the tumor suppressor PTEN, a phosphatase that functions antagonistically to PI3K. mTOR regulates cell growth, motility, and metabolism by forming two multiprotein complexes, mTORC1 and mTORC2, which are composed of special binding partners. These complexes are sensitive to distinct stimuli. mTORC1 is sensitive to nutrients and mTORC2 is regulated via PI3K and growth factor signaling. Since rapamycin and its analog are less effective in treatment of GB, we used novel ATP-competitive dual inhibitors of mTORC1 and mTORC2, namely, Torin1, Torin2, and XL388. Torin1 showed similar effects only at higher doses. Another small mol. compound, XL388 suppressed cell proliferation at a higher dose but failed to inhibit cell migration. In addition, formulation of third generation mTOR inhibitor “”Rapalink-1″” may provide new aspects to target mTOR pathways. Numerous inhibitors are currently being used in clin. trials that are aimed to target activated mTOR pathways.
Advances in Biological Regulation published new progress about AKT-interacting protein AKTIP Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1223001-51-1 belongs to class naphthyridine, and the molecular formula is C24H15F3N4O, SDS of cas: 1223001-51-1.
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem