Noser, Ahmed A. published the artcileSynthesis, in silico and in vitro assessment of new quinazolinones as anticancer agents via potential AKT inhibition, Computed Properties of 116-63-2, the publication is Molecules (2020), 25(20), 4780, database is CAplus and MEDLINE.
A series of novel quinazolinone I [ R = 4-carboxyphenyl, 3-carboxyphenyl, 4-hexadecoxycarbonylphenyl, etc.] was synthesized and examined for their cytotoxicity to HepG2, MCF-7, and Caco-2 in an MTT assay. Among these derivatives, compounds I [ R = 4-hexadecoxycarbonylphenyl] and I [ R = (2-methylbutanoyl)oxyphenyl] exhibited significant cytotoxic activity against Caco-2, HepG2, and MCF-7 cancer cells. Compound I [ R = 4-hexadecoxycarbonylphenyl] had more significant inhibitory effects than compound I [ R = (2-methylbutanoyl)oxyphenyl] on Caco-2, HepG2, and MCF-7 cell lines, with IC50 values of 23.31 ± 0.09, 53.29 ± 0.25, and 72.22 ± 0.14μM, resp. The AKT pathway was one of human cancer’s most often deregulated signals. AKT was also overexpressed in human cancers such as glioma, lung, breast, ovarian, gastric, and pancreas. A mol. docking study was performed to analyze the inhibitory action of newly synthetic quinazolinone derivatives against Homo sapiens AKT1 protein. Mol. docking simulations were found to be in accordance with in-vitro studies, and hence supported the biol. activity. The results suggested that compounds I [ R = 4-hexadecoxycarbonylphenyl] and I [ R = (2-methylbutanoyl)oxyphenyl] could be used as drug candidates for cancer therapy via its potential inhibition of AKT1 as described by docking study.
Molecules published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Computed Properties of 116-63-2.
Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem