254-60-4, Name is 1,8-Diazanaphthalene, belongs to naphthyridine compound, is a common compound. Application In Synthesis of 1,8-DiazanaphthaleneIn an article, once mentioned the new application about 254-60-4.
A series of nalidixic acid-based hydrazones and their Au III, PtIV metal complexes have been synthesized and evaluated for their in vitro antimicrobial activity based on dimension of the diameter of inhibition zone formed round the well against a panel of reference strains of microorganisms, including Gram-positive bacteria, Gram-negative bacteria, and fungi Candida albicans and Candida tropicalis. Nalidixic acid hydrazone derivatives were obtained by condensation reaction of nalidixic acid hydrazide with substituted aromatic aldehydes and acetophenone. The complexes of Au III, Pt IV metals with nalidixic acid hydrazone derivatives were synthesized. All compounds have been characterized by elemental analysis, FT-IR,1H NMR and13C NMR spectra. The antimicrobial activity indicated that all ligands and metal complexes showed significant activity of anti-bacterial, antifungal activity comparable to that of parent and standard.
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Reference£º
1,43-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N37 – PubChem