Category: 15936-10-4

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 15936-10-4. In a patent£¬Which mentioned a new discovery about 15936-10-4, molcular formula is C8H5ClN2, introducing its new discovery.

MERCK SHARP & DOHME LIMITED

The present invention provides a compound of formula (I): Y-J-NH-Z wherein: Y is a quinoline or isoquinoline optionally substituted with one or two substituents independently chosen from hydroxy, halogen, haloC 1-4alkyl, C1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, nitro and amino; J is pyridine, pyridazine, pyrazine, pyrimidine or triazine optionally substituted with one or two substituents independently chosen from hydroxy, halogen, haloC1-4alkyl, C1-4alkyl, C3-5cycloalkyl, C1-4alkoxy, hydroxyC1-4alkyl, cyano, hydroxy, C1-4cycloalkoxy, C1-4alkylthio, haloC1-4 alkoxy, nitro, Q, (CH2)pQ, NR2R 3,-(CH2)pNR2R3 and-O(CH2)pNR2R3; wherein J is substituted at positions meta to each other by NH and Y; and Z is phenyl or pyridyl optionally substituted with one or two substituents independently selected from halogen, haloC1-4alkyl, C1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, nitro and amino; Q is phenyl, a five-membered heterocyclic ring containing one, two, three or four heteroatoms chosen from O, N and S, at most one heteroatom being O or S, or a six-membered heterocyclic ring containing one, two or three nitrogen atoms, optionally substituted by C1-4alkyl; each R2 and R3 is chosen from H and C1-4 alkyl, or R2 and R3, together with the nitrogen atom to which they are attached, may form a six-membered ring optionally containing an oxygen atom or a further nitrogen atom, which ring is optionally substituted by C1-4alkyl or Q; p is 1, 2 or 3; or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising it; its use in methods of therapy; use of it for manufacturing medicaments; and methods of using it to treat diseases requiring administration of a VR1 antagonist such as pain, cough, GERD and depression.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, 15936-10-4, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 15936-10-4

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1,478-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N472 – PubChem

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 15936-10-4, Name is 2-Chloro-1,8-naphthyridine. In a document type is Conference Paper, introducing its new discovery., 15936-10-4

Our quest for ligands toward the synthesis of functional metal string complexes started from alpha-pyridylamido anions. With the modulation of naphthyridylamido anions, the ligands carry less negative charge to be balanced and, thus, to some extent, can tune the oxidation state of the metal centers and the strength of metal?metal interactions. For example, the formation of Ni2 3+, a mixed-valence moiety, has been demonstrated. In this paper, high-bond-order units of M2 (Mo2 or Ru2) and Ni2 3+ are introduced and supported by four equatorial ligands of the bisnaphthyridylamido anion (bna?). The resulting compounds are [Ni2Mo2Ni(bna)4Cl2](PF6)3 (1), [Ni2Mo2Ni(bna)4(NCS)2](PF6)3 (2), and [Ni2Ru2Ni(bna)4Cl2](ClO4)3 (3). X-ray crystallography reveal quadruply bonded characteristics with Mo?Mo distances of 2.133(2) and 2.109(2) A for 1 and 2, respectively. The Ni2 moieties have a short Ni?Ni distance of 2.331(5) for 1 and 2.334(4) A for 2, suggesting the formation of mixed-valence Ni2 3+ units. It appears that there are no significant metal?metal interactions between Mo2 and its neighboring Ni centers. Characterization using magnetism, voltammetry, electronic absorption, and single-molecule conductance, however, shows significant influence of Mo2 on the properties of the metal string complexes.

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1,484-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N478 – PubChem

15936-10-4, In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 15936-10-4, name is 2-Chloro-1,8-naphthyridine, introducing its new discovery.

The Dow Chemical Company

Novel 2-naphthyridinyloxy(or thio)phenoxy propanoic acid compounds of the formula STR1 wherein STR2 represents a 6 membered nitrogen containing an aromatic ring which forms a 1,5-, 1,6-, 1,7- or 1,8-naphthyridinyl moiety with the adjoining pyridine ring, said naphthyridinyl moiety optionally substituted at the 6 position of the naphthyridinyl moiety with a chloro, bromo, iodo, CF3, or fluoro atom; A represents O or S; and agriculturally acceptable salts, esters, ethers, and amides thereof, are useful as fungicides and herbicides, particularly effective against grassy weeds.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.15936-10-4, you can also check out more blogs about15936-10-4

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1,481-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N475 – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. 15936-10-4. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.15936-10-4, Name is 2-Chloro-1,8-naphthyridine, molecular formula is C8H5ClN2, introducing its new discovery.

Two new linear pentanickel complexes [Ni,(bna)4(Cl) 2][PF6]2 (1) and [Ni5(bna) 4(Cl)2][PF6]4 (2; bna = binaphthyridylamide). were synthesized and structurally characterized. A derivative of 1, [Ni5(bna)4(NCS)2][NCS] 2 (3), was also isolated for the purpose of the conductance experiments carried out in comparison with [Ni5(tpda) 4-(NCS)2] (4; tpda = tripyridyldiamide). The metal framework of complex 2 is a standard [Ni5]10+ core, isoelectronic with that of [Ni5(tpda)4Cl2] (5). Also as in 5. complex 2 has an antiferromagnetic ground state (J = -15.86 cm-1) resulting from a coupling between the terminal nickel atoms, both in high-spin sate (5=1). Complex 1 displays the first characterized linear nickel framework in which the usual sequence of NiII atoms has been reduced by two electrons. Each dinickel unit attached to the naphthyridyl moieties is assumed to undergo a one-electron reduction, whereas the central nickel formally remains NiII. DFT; calculations suggest that the metal framework of the mixed-valence complex 1 should be described as intermediate between a localized picture corresponding to NiII- NiI-NiII-NiI-NiII and a fully delocalized model represented as (Ni2)3+-Ni II-(Ni2)3+. Assuming the latter model, the ground state of 1 results from an antiferromagnetic coupling (J = -34.03 cm -1) between the two (Ni2)3+ fragments, considered each as a single magnetic centre (5 = 3/2). An intervalence charge-transfer band is observed in the NIR spectrum of 1 at 1186nm, suggesting, in accordance with DFT calculations, that 1 should be assigned to Robin-Day class II of mixed-valent complexes. Scanning tunnelling microscopy (STM) methodology was used to assess the conductance of single molecules of 3 and 4. Compound 3 was found ? 40% more conductive than 4, a result that could be assigned to the electron mobility induced by mixed-valency in the naphthyridyl fragments.

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1,488-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N482 – PubChem

15936-10-4, Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter. In a patent£¬patent Assignee is Gao Chunji, Which mentioned a new discovery about 15936-10-4, molecular formula is C8H5ClN2.

Zhejiang Huaxian Optoelectric Technology Co., Ltd.; Gao Chunji; Wang Huayue; Qian Ye; Huang Di

The present invention discloses a green phosphorescent compound and an organic electroluminescent device, using the compound as a dopant of a green phosphorescent compound represented by Formula, below an anode, hole injection layer, hole transport layer, emission layer, electron injection layer and a cathode, (I) which are sequentially deposited with each other. I In formula, R1 , R2 , R3 , R4 , R5 , R6 , R7 And R8 Independently selected from hydrogen, deuterium, halogen, alkyl, cycloalkyl, heteroalkyl, aryl alkyl, alkoxy, aryl, alkyl, alkynyl, aryl-cycloalkenyl,isobutyronitrile, isobutyronitrile, sulphonyl, sulphinyl,X sulfonyl, phosphonylsulphonylsulphonylsulphonylphosphoryl and combinations, thereof. 1 X X-ray tube9 A compound selected from the group consisting of substituted or unsubstituted naphthyridine ;X selected from substituted or unsubstituted phenyl ;Y pyridine, pyrimidine, pyrazine, pyridazine, is selected from ;n or 0, 1 2. (by machine translation)

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. 15936-10-4

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1,477-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N471 – PubChem

2-Chloro-1,8-naphthyridine, cas is 15936-10-4, it is a common heterocyclic compound, the naphthyridine compound, its synthesis route is as follows.

2-chloro-1,8-naphthyridine (89 mg, 0.54 mmol), 5-(trans-3-aminocyclobutyl)-7,7-dimethyl-5H-pyrrolo[2,3-b]pyrazin-6(7H)-one (100 mg, 0.431 mmol), and cesium carbonate (202 mg, 0.620 mmol) were suspended in dry dimethylformamide (0.86 mL) under nitrogen and heated to 100 C. for 18 h. The mixture was cooled and extracted with ethyl acetate and water. The phases were separated and the organic was dried with magnesium sulfate before evaporating to dryness under reduced pressure. Purification using the ISCO (0-100% EtOAc in hexane), gave the desired 5-(trans-3-((1,8-naphthyridin-2-yl)amino)cyclobutyl)-7,7-dimethyl-5H-pyrrolo[2,3-b]pyrazin-6(7H)-one (32 mg, 0.089 mmol, 21% yield) as a light yellow solid. 1H NMR (300 MHz, CHLOROFORM-d) delta: ppm 1.45 (s, 6H) 2.42 (ddd, J=13.88, 9.28, 3.29 Hz, 2H) 3.44-3.62 (m, 2H) 5.22-5.38 (m, 2H) 6.71 (d, J=8.92 Hz, 1H) 7.16 (dd, J=7.82, 4.46 Hz, 1H) 7.79-7.98 (m, 2H) 8.11 (q, J=3.12 Hz, 2H) 8.84 (dd, J=4.38, 1.90 Hz, 1H)., 15936-10-4

15936-10-4 is used more and more widely, we look forward to future research findings about 2-Chloro-1,8-naphthyridine

Reference£º
Patent; AMGEN INC.; Allen, Jennifer R.; Amegadzie, Albert; Andrews, Kristin L.; Brown, James; Chen, Jian J.; Chen, Ning; Harrington, Essa Hu; Liu, Qingyian; Nguyen, Thomas T.; Pickrell, Alexander J.; Qian, Wenyuan; Rumfelt, Shannon; Rzasa, Robert M.; Yuan, Chester Chenguang; Zhong, Wenge; US2013/225552; (2013); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

15936-10-4, 2-Chloro-1,8-naphthyridine is a naphthyridine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,15936-10-4

2-chloro-1,8-naphthyridine (89 mg, 0.54 mmol), 5-(trans-3-aminocyclobutyl)-7,7-dimethyl-5H-pyrrolo[2,3-b]pyrazin-6(7H)-one (100 mg, 0.431 mmol), and cesium carbonate (202 mg, 0.620 mmol) were suspended in dry dimethylformamide (0.86 mL) under nitrogen and heated to 100 C. for 18 h. The mixture was cooled and extracted with ethyl acetate and water. The phases were separated and the organic was dried with magnesium sulfate before evaporating to dryness under reduced pressure. Purification using the ISCO (0-100% EtOAc in hexane), gave the desired 5-(trans-3-((1,8-naphthyridin-2-yl)amino)cyclobutyl)-7,7-dimethyl-5H-pyrrolo[2,3-b]pyrazin-6(7H)-one (32 mg, 0.089 mmol, 21% yield) as a light yellow solid. 1H NMR (300 MHz, CHLOROFORM-d) delta: ppm 1.45 (s, 6H) 2.42 (ddd, J=13.88, 9.28, 3.29 Hz, 2H) 3.44-3.62 (m, 2H) 5.22-5.38 (m, 2H) 6.71 (d, J=8.92 Hz, 1H) 7.16 (dd, J=7.82, 4.46 Hz, 1H) 7.79-7.98 (m, 2H) 8.11 (q, J=3.12 Hz, 2H) 8.84 (dd, J=4.38, 1.90 Hz, 1H).

15936-10-4 2-Chloro-1,8-naphthyridine 5152838, anaphthyridine compound, is more and more widely used in various fields.

Reference£º
Patent; AMGEN INC.; Allen, Jennifer R.; Amegadzie, Albert; Andrews, Kristin L.; Brown, James; Chen, Jian J.; Chen, Ning; Harrington, Essa Hu; Liu, Qingyian; Nguyen, Thomas T.; Pickrell, Alexander J.; Qian, Wenyuan; Rumfelt, Shannon; Rzasa, Robert M.; Yuan, Chester Chenguang; Zhong, Wenge; US2013/225552; (2013); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to naphthyridine compound, name is 2-Chloro-1,8-naphthyridine, and cas is 15936-10-4, its synthesis route is as follows.,15936-10-4

EXAMPLE 2 Preparation of 2-(4-(1,8-naphthyridin-2-yloxy)phenoxy)propanoic acid STR9 A 3-necked flask was equipped with a thermometer, a magnetic stirrer, a reflux condenser and a nitrogen line and flushed with nitrogen. The flask was charged with 15 ml of hexane and 1.38 gm (28.8 m moles) of 50% NaH/oil dispersion. After stirring for 10 minutes the hexane was decanted and replaced with 5 ml of DMSO followed by the dropwise addition of a solution of 2.18 gm (12 m moles) of 2-(4-hydroxyphenoxy)propanoic acid in 5 ml of DMSO. The mixture was warmed to 60 C. and a solution of 1.97 gm of 2-chloro-1,8-naphthyridine in 10 ml of DMSO was added. After warming the reaction mixture at 95 C. for one hour, the mixture was cooled to room temperature and water cautiously added. The solution was extracted with methylene chloride and the aqueous phase neutralized with acetic acid to give a white precipitate. The aqueous mixture was extracted with CH2 Cl2 and the organic layer washed twice with water, dried over Na2 SO4 and evaporated to dryness to give 3.3 gm of yellow solid which could not be redissolved in ether or CH2 Cl2.

With the complex challenges of chemical substances, we look forward to future research findings about 15936-10-4,belong naphthyridine compound

Reference£º
Patent; The Dow Chemical Company; US4472193; (1984); A;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to naphthyridine compound, name is 2-Chloro-1,8-naphthyridine, and cas is 15936-10-4, its synthesis route is as follows.,15936-10-4

Example 82; 5-Methvl-6- (1, 8-naphthyridin-2-yl)-N [4-trifluoromethvl phenvl] pyrimidin-4-amine; To a mixture of Description 95 (200 mg, 0.7 mmol), Description 92 (115 mg, 0.7 mmol) and Pd (PPh3) 4 (80 mg, 0.07 mmol) in anhydrous 1, 4-dioxane (4 ml) was added hexamethylditin (0. 145 ml, 0.7 mmol). The mixture was heated at 190C for 15 min in a microwave reactor (Personal Chemistry-Smith synthesizer). The cooled reaction mixture was loaded directly onto a silica gel chromatography column and eluted with 2% MeOH + 0. 5% NH40H in DCM. The product was further purified by mass directed HPLC to give the title compound as a white solid (50 mg, 18%). 1H NMR (500 MHz, CDCl3) 2.70 (3 H, s), 6.94 (1 H, s), 7. 58 (1 H, dd, J8.1 and 4.2), 7.64 (2 H, d, J8.6), 7.84 (2 H, d, J8.6), 8. 25 (1 H, d, J8. 5), 8.29 (1 H, dd, J8. 1 and 1. 9), 8.38 (1 H, d, J 8. 4), 8. 81 (1 H, s), 9.20 (1 H, dd, J4.2 and 1.9) ; mlz (ES+) 382 (M+H+).

With the complex challenges of chemical substances, we look forward to future research findings about 15936-10-4,belong naphthyridine compound

Reference£º
Patent; MERCK SHARP & DOHME LIMITED; WO2005/47279; (2005); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

2-Chloro-1,8-naphthyridine, cas is 15936-10-4, it is a common heterocyclic compound, the naphthyridine compound, its synthesis route is as follows.

Description 94; 6-(1 8-Naphthyridin-2-yl) pvrimidin-4-amine; To a mixture of Description 92 (2.52 g, 15. 3 mmol), hexamethylditin (5.0 g, 15.3 mmol), lithium chloride (1.95 g, 45.9 mmol), and copper (I) iodide (291 mg, 1.53 mmol) in anhydrous 1,4-dioxane (50 ml) was added Pd (PPh3) 4 (884 g, 0.77 mmol). The mixture was de-gassed three times, and heated at 100C overnight. The mixture was cooled and diluted with EtOAc (120 ml) and washed with a 10% potassium fluoride solution (200 ml). The organic layer was washed with sat. NaCl (50 ml), dried over Na2SO4, filtered, and evaporated. The residue was taken up in anhydrous 1,4-dioxane (75 ml), and Description 93 (1.55 g, 7 mmol), lithium chloride (1.78 g, 42 mmol), and copper (I) iodide (266 mg, 1.4 mmol) added, followed by Pd (PPh3) 4 (808 mg, 0.7 mmol). The mixture was de-gassed 3 times and heated at 100C for 3 days. The mixture was poured into water (200 ml), and extracted with EtOAc (2 x 100 ml), the combined EtOAc layers were washed with water (150 ml), sat. NaCl (100 ml), dried over Na2SO4, filtered and evaporated. The residue was purified by column chromatography on silica (eluent: 2% MeOH in DCM + 0.5% NH40H) to give the title compound (100 mg, 3%).’H NMR (360 MHz, DMSO-d6) 7.18 (2 H, br s), 7.66-7. 86 (3 H, m), 8.55 (1 H, dd, J 8.1 and 1. 8), 8. 58 (1 H, d, J4. 2), 8.64 (1 H, d, J8. 4), 9.16 (1 H, dd, J4. 2 and 2.1)., 15936-10-4

With the rapid development of chemical substances, we look forward to future research findings about 2-Chloro-1,8-naphthyridine

Reference£º
Patent; MERCK SHARP & DOHME LIMITED; WO2005/47279; (2005); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem