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The adducts WOF4.napy and WOF4.dmnapy were prepared from the reaction of WOF4 with 1,8-naphthyridine (napy) and 2,7-dimethyl-1,8-naphthyridine (dmnapy) in dichloromethane.Both adducts were characterized by elemental analysis, X-Ray powder data and infrared absorption spectroscopy.Their solubility in the usual organic solvents was found to be negligible and the trace amounts of species present in the solutions were identified as ionic derivatives originating from sidereactions.

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1,47-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N41 – PubChem

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In this paper, a novel electrochemical sensor was developed for the rapid detection of G-G mismatched DNA based on hexaammineruthenium(III) chloride ([Ru(NH3)6]Cl3) as a redox indicator. The sensor platform was constructed by immobilizing small molecules (NC-linker) on the gold electrode via amide bonds. The as-prepared NC-linker as the nucleic acids recognition molecule can interact with the G base of DNA. After the sensor was incubated with G-G mismatched DNA, the double-stranded DNA (dsDNA) acted as carriers of the signal tags-[Ru(NH3)6]Cl3, which resulted in a remarkable electrochemical signal. More binding of [Ru(NH3)6]Cl3 led to increases of the electrochemical signal. Other mismatched DNA produced only a low response, as well as complementary DNA. Thus G-G mismatched DNA can be easily discriminated from other mismatched and complementary DNA based on the sensor. Furthermore, the method was simple, rapid and repeatable for the detection of G-G mismatched DNA. The selective detection of target dsDNA was achieved by a relative current ratio of the target and control DNA. These results demonstrated that this strategy could provide great promise for the rapid and specific detection of other sequence-specific DNA.

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1,302-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N296 – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: 254-60-4, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 254-60-4, name is 1,8-Diazanaphthalene. In an article£¬Which mentioned a new discovery about 254-60-4

Based on the ligand (2,7-bis(alpha-pyrimidylamino)-1,8-naphthyridine (H2bpmany)), a linear pentachromium complex [Cr5(mu5-bpmany)4Cl2]PF6 (1, mu5-bpmany = 2,7-bis(a-pyrimidyla-mino)-1,8-naphthyridine) was synthesized. The crystal structure of compound 1 has been characterized by X-ray crystallography. Interestingly, one metal atom in the center is missing in this linear chain, leading to the defective pentachromium metal string structure which is similar with the reported complex [Cr5(mu5-dpznda)4Cl2] (2, dpznda = N2,N7-di(pyrazin-2-yl)-1,8-naphthyridine-2,7-diamine). The central Cr(?) ion of 1 is eight-coordinated and is also rare in the chromium complex. The reaction of carbon dioxide with propylene oxide that generates propylene carbonate (PC) when catalyzed by [Cr5(mu5-bpmany)4Cl2]PF6 was investigated. Different reaction conditions including temperature and pressure were studied to optimize the reaction conditions.

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1,276-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N270 – PubChem

Reference of 254-60-4, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 254-60-4, molcular formula is C8H6N2, introducing its new discovery.

Single-chromophore single-molecule photocatalysts for the conversion and storage of solar energy into chemical bonds are rare, inefficient and do not use significant portions of the visible spectrum. Here we show a new, air-stable bimetallic scaffold that acts as a single-chromophore photocatalyst for hydrogen-gas generation and operates with irradiation wavelengths that span the ultraviolet to the red/near-infrared. Irradiation in acidic solutions that contain an electron donor results in the catalytic production of hydrogen with 170 ¡À 5 turnovers in 24 hours and an initial rate of 28 turnovers per hour. The catalysis proceeds through two stepwise excited-state redox events?atypical of the currently known homogeneous photocatalysis?and features the storage of multiple redox equivalents on a dirhodium catalyst enabled by low-energy light.

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1,281-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N275 – PubChem

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A large number of experimental and computational gas-phase basicity data for monocyclic and polycyclic aromatic azines, including values taken from the recent literature, were examined to explore how internal (structural) effects influence gas-phase basicity (GB) and/or proton affinity (PA) of aza nitrogen. Substituent electron withdrawing effects on the pyridine ring may induce a decrease in PA as large as 200?kJ?mol?1. Polarizability of alkyl and aryl groups increases experimental PA by up to 100?kJ?mol?1, as in the case of 1- and 2-aza[6]helicene. The many computational studies involving azines, often performed in search of ?superbasicity?, were reviewed. Calculations at the DFT level, carried out on chelating azine systems bearing strong electron donor substituents, yielded PAs much higher than the current upper limit of the experimental scale. The structural variety of aromatic azines, from hexaazabenzene to the phosphazeno derivative of azacalix[3](2,6)pyridine, generates aza-nitrogen PAs ranging from ca. 650 up to 1300?kJ?mol?1.

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1,235-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N229 – PubChem

Synthetic Route of 254-60-4, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 254-60-4, 1,8-Diazanaphthalene, introducing its new discovery.

Due to their availability, price and biological relevance, the use of catalysts based on 3d transition metals is of substantial importance for the synthesis of industrial chemicals, but also for organic synthesis in general. Hence in recent years, especially in homogeneous catalysis, the use of such Earth-abundant, biocompatible metals has become a major area of interest. However, to achieve reactivity comparable to that of noble-metal catalysts, generally sophisticated ligands?typically expensive phosphorus derivatives?have to be used. Here, we report the chemoselective reduction of quinolines and related N-heterocycles by molecular hydrogen, using a simple Mn(i) complex [Mn(CO)5Br]. Under very mild reaction conditions this catalytic system is able to reduce a wide range of quinolines, affording high yields of the corresponding tetrahydroquinolines, a scaffold present in many bioactive compounds, including marketed pharmaceuticals. Mechanistic studies reveal the formation of the active catalyst and also show the important role of a concomitantly formed Mn(ii) species and HBr for the hydrogenation of the heterocyclic substrates.

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1,216-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N210 – PubChem

Synthetic Route of 254-60-4, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.254-60-4, Name is 1,8-Diazanaphthalene, molecular formula is C8H6N2. In a article£¬once mentioned of 254-60-4

In many repeat diseases, such as Huntington?s disease (HD), ongoing repeat expansions in affected tissues contribute to disease onset, progression and severity. Inducing contractions of expanded repeats by exogenous agents is not yet possible. Traditional approaches would target proteins driving repeat mutations. Here we report a compound, naphthyridine-azaquinolone (NA), that specifically binds slipped-CAG DNA intermediates of expansion mutations, a previously unsuspected target. NA efficiently induces repeat contractions in HD patient cells as well as en masse contractions in medium spiny neurons of HD mouse striatum. Contractions are specific for the expanded allele, independently of DNA replication, require transcription across the coding CTG strand and arise by blocking repair of CAG slip-outs. NA-induced contractions depend on active expansions driven by MutSbeta. NA injections in HD mouse striatum reduce mutant HTT protein aggregates, a biomarker of HD pathogenesis and severity. Repeat-structure-specific DNA ligands are a novel avenue to contract expanded repeats.

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1,206-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N200 – PubChem

Reference of 254-60-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.254-60-4, Name is 1,8-Diazanaphthalene, molecular formula is C8H6N2. In a Article£¬once mentioned of 254-60-4

A general catalytic hydrogen transfer-mediated alpha-functionalization of 1,8-naphthyridines is reported for the first time that benefits from a hydrogen transfer-mediated activation mode for non-activated pyridyl cores. The pyridyl alpha-site selectively couples with the C8-site of various tetrahydroquinolines (THQs) to afford novel alpha-functionalized tetrahydro 1,8-naphthyridines, a class of synthetically useful building blocks and potential candidates for the discovery of therapeutic and bio-active products. The utilization of THQs as inactive hydrogen donors (HDs) appears to be a key strategy to overcome the over-hydrogenation barrier and address the chemoselectivity issue. The developed chemistry features operational simplicity, readily available catalyst and good functional group tolerance, and offers a significant basis for further development of new protocols to directly transform or functionalize inert N-heterocycles.

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1,87-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N81 – PubChem

Reference of 254-60-4, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 254-60-4, 1,8-Diazanaphthalene, introducing its new discovery.

In the amination of 1,X-naphthyridines with potassium amide in liquid ammonia at about -35 to -40 deg C the initial adduct formation is charge controlled.Thus, at these temperatures the site with the lowest electron density is most susceptible for amide attack (C-2 in 1,5-naphthyridine, C-2 in 1,6-naphthyridine, C-2 and C-8 in 1,7-naphthyridine, and C-2 in 1,8-naphthyridine), as proven by NMR spectroscopy.When the temperature was raised to about 10 deg C, the site of addition has been found to change for 1,5- and 1,7-naphthyridine (NMR spectroscopy): from C-2 to C-4 in 1,5-naphthyridine and from C-2 and C-8 to C-8 only in 1,7-naphthyridine.In case of 1,6- and 1,8-naphthyridines no change was observed.Thus, the amination at about 10 deg C is a process which is thermodynamically controlled.The several factors which contribute to the stability of these addition products have been discussed.It has been found that the anionic ? adducts 2(4,8)-aminodihydro-1,X-naphthyridinides can be easily oxidized with potassium permanganate into their corresponding 2(4,8)-amino-1,X-naphthyridines.

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1,131-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N125 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. HPLC of Formula: C8H6N2. Introducing a new discovery about 254-60-4, Name is 1,8-Diazanaphthalene

By reaction of [NBu4]2[Pt2(muC6F 5)2(C6F5)4] with 1,8-naphthyridine (napy), [NBu4][Pt(C6F5)3(napy)] (1) is obtained. This compound reacts with cis-[Pt(C6F5)2(THF)2] to give the dinuclear derivative [NBu4][Pt2(mu-napy)(mu-C6F 2)-(C6F5)4] (2). The reaction of several HX species with 2 results in the substitution of the bridging C6F5 by other ligands (X) such as OH (3), Cl (4), Br (5), I (6), and SPh (7), maintaining in all cases the naphthyridine bridging ligand. The structure of 3 was determined by single-crystal X-ray diffraction. The compound crystallizes in the monoclinic system, space group P21 /n, with a = 12.022(2) A, b = 16.677(3) A, c = 27.154(5) A, beta= 98.58(3), V = 5383.2(16) A3, and Z = 4. The structure was refined to residuals of R = 0.0488 and Rw = 0.0547. The complex consists of two square-planar platinum(II) fragments sharing a naphthyridine and OH bridging ligands, which are in cis positions. The short Pt-Pt distance [3.008(1) A] seems to be a consequence of the bridging ligands.

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1,49-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N43 – PubChem