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Ever since it was discovered and used widely in the synthesis of different organic compounds, quinoline became an interesting framework among chemists and pharmacists due to its unique properties. There are many familiar named reactions developed for the synthesis of quinoline based structures, among which the Friedlaender reaction plays an important role. This method involves the condensation between 2-aminobenzaldehydes and a ketone. By developing the Friedlaender synthesis, different types of heterocycles have been prepared in addition to the quinolines. In this chapter, the focus is on the applicability of the Friedlaender reaction to the synthesis of various types of heterocyclic compounds.

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1,119-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N113 – PubChem

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Wuyi University; Chen Xiuwen; Zhang Min; Li Yibiao

The invention discloses a 2 – (tetrahydroquinoline – 6 – yl) – tetrahydro – 1, 8 – naphthyridine class compound and its preparation method and application, the compounds of the formula I shown molecule formula: Wherein R states the type I in1 Is phenyl, nitrophenyl or halogenated phenyl; R2 Is hydrogen or methyl; R3 Is hydrogen or methyl; R4 Is hydrogen or methyl. The preparation method comprises the following steps: S1, in the reaction container, adding tetrahydroquinoline compound and 1, 8 naphthyridine class compounds, added to the tetrahydroquinoline compound quality of 1 – 5% of the metal catalyst, adding acid and a solvent, in the 80 C -160 C stirring for 5 – 24 hours; S2, after the reaction cooled to room temperature, filtered, and steaming and removing the solvent under reduced pressure to get the crude product can be, of the crude product by column chromatography purification. (by machine translation)

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Edges of carbon materials have been known to work as active sites for various applications such as catalysts, adsorbent, and electrodes, but selecting precursors for carbon materials with controlled edges in the absence of metallic substrate is challenging. This work developed a method to select the superior precursors instantaneously using molecular dynamic simulation. This simulation predicted that hydrogen in precursors gasified and the hydrogen attacked the active sites in precursors upon carbonization, causing the decrement of active sites. Thus, it is essential to reduce the concentration of hydrogen in precursors and it is also necessary to introduce reactive functional groups near the active site to protect the active sites. We indeed synthesized the selected precursors such as diethynyl anthracene, diethynyl chrysene, divinyl naphthyridine, and divinyl phenanthroline and proved that edges in those precursors were maintained even after carbonization at 773 K using diffuse reflectance infrared Fourier transform and X-ray photoelectron spectroscopy with the aid of spectra simulated by density functional theory calculation. Especially, ca. 100% of edge structures of zigzag edges and armchair edges in diethynyl anthracene and diethynyl chrysene was maintained even after carbonization at 773 K.

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Supramolecular polymers are polymeric arrays of monomeric units that are connected together via highly directional and reversible noncovalent interactions, resulting in polymeric properties in solution and the bulk. Because of the dynamic nature of the noncovalent interactions, supramolecular polymers show distinct properties such as reversibility, self-healing, stimuli-responsiveness and good processability. Here, we provide an overview of the fabrication of supramolecular polymers. We introduce the driving forces for supramolecular polymerization, summarize the topological structures of supramolecular polymers, and highlight the methods and strategies for the fabrication of supramolecular polymers in a controllable manner. It is evident that supramolecular polymers based on noncovalent interactions are complementary to traditional polymer science and represent a new growth point by marrying supramolecular science with polymer science.

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2-Methyl-7-amino-1,8-naphthyridin-4-ol (1) reacts with different aldehydes to form 7-aminosubstituted-2-methyl- 1,8-naphthyridin-4-ol derivatives (2a-j). These naphthyridines2a-j are cyclised to azetidinones (3a-j) by microwave irradiation of 2a-j with chloroacetylchloride and a mild base to give 4-substituted-chloro-1-(4-hydroxy-2-methyl- 1,8-naphthyridin-7-yl)azetidin-2-ones.

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L form bacteria do not have a cell wall and are thought to require medium of high osmolality for survival and growth. In this study we tested whether L forms can adapt to growth in lower osmolality medium. We first tested the Escherichia coli L form NC-7, generated in 1987 by Onoda following heavy mutagenesis. We started with growth in osmoprotective medium (~ 764 mOsm kg?1) and diluted it stepwise into medium of lower osmolality. At each step the cells were given up to 10 days to adapt and begin growing, during which they apparently acquired multiple new mutations. We eventually obtained a strain that could grow in LB containing only 34 mM NaCl, 137 mOsm kg?1 total. NC-7 showed a variety of morphologies including spherical, angular and cylindrical cells. Some cells extruded a bud that appeared to be the outer membrane enclosing an enlarged peri-plasm. Additional evidence for an outer membrane was sensitivity of the cells to the compound CHIR-090, which blocks the LPS pathway, and to EDTA which chelates Mg that may stabilize and rigidify the LPS in the outer membrane. We suggest that the mechanical rigidity of the outer membrane enables the angular shapes and provides some resistance to turgor in the low-osmolality media. Interestingly, cells that had an elongated shape underwent division shortly after addition of EDTA, suggesting that reducing the rigidity of the outer membrane under some turgor pressure induces division before lysis occurs. We then tested a well-characterized L form from Bacillus subtilis. L form strain LR-2L grew well with sucrose at 1246 and 791 mOsm kg?1. It survived when diluted directly into 440 mOsm kg?1 but grew poorly, achieving only 1/10 to 1/5 the density. The B. subtilis L form apparently adapted to this direct dilution by rapidly reducing cytoplasmic osmolality.

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A novel fluorescent probe 1 has been synthesized by a microwave reaction, and its ion-binding and fluorescence-sensing properties have been investigated under different solvent conditions. The analysis results indicated that probe 1 can act as a multiple analysis probe by simply tuning the solvent. Probe 1 exhibited high selectively toward Hg2+ through fluorescence quenching in H2O/DMF. In H2O/1,4-dioxane solution, probe 1 selectively recognized and discriminated between Ag+ and Hg2+ displaying ratiometric behaviour. Moreover, probe 1 readily recognized the anion F? via the ratiometric fluorescent mode in CH3CN. Furthermore, distinct colour changes were observed under UV light, which can be seen by the naked eye and thus used for distinguishing Hg2+, Ag+ and F? from the other ions screened herein using probe 1. Interestingly, almost pure white light emission was evident by simply tuning the F? anion-concentration, which makes this system a potential candidate for smart and tunable luminescent materials.

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1,286-Naphthyridine – Wikipedia,
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Reaction of dichlorocarbene with diazines in the presence of dimethyl maleate and dimethyl acetylenedicaroxylate involves intermediate formation of ylides, namely cycloimmoniodichloromethanides, followed by 1,3-dipolar cycloaddition of the latter to dipolarophiles. This carbene-ylide sequence was used to synthesize chloro-substituted pyrrolo[1,2-6]pyridazines, pyrrolo[1,2-c]- and pyrrolo[1,2-a]pyrimidines, pyrrolo[1,2-a]phthalazine, pyrrolo[1,2-a]-, pyrrolo[1,2-c]-, and pyrrolo[2,1-b]quinazolines, pyrrolo[1,2-a]-quinoxalines, and pyrrolo[1,2-a]naphthiridines. The cycloaddition is stereo- and regioselective, which suggests a concerted reaction mechanism. The regioselectivity of the cycloaddition is correctly predicted in terms of the PMO theory on the basis of MNDO electronic parameters of halogenated cycloimmonium ylides.

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1,158-Naphthyridine – Wikipedia,
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C16H14N2, orthorhombic, P212121, a = 6.449(8) A, b = 10.548(14) A, c = 17.84(2) A, V = 1213(3) A3, Z = 4, Rgt(F) = 0.0406, wRref(F2) = 0.0933, T = 296(2) K.

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1,148-Naphthyridine – Wikipedia,
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Nitrogen bases containing one or more pushing amino-group(s) directly linked to a pulling cyano, imino, or phosphoimino group, as well as those in which the pushing and pulling moieties are separated by a conjugated spacer (C=X)n, where X is CH or N, display an exceptionally strong basicity. The n- conjugation between the pushing and pulling groups in such systems lowers the basicity of the pushing amino-group(s) and increases the basicity of the pulling cyano, imino, or phosphoimino group. In the gas phase, most of the so-called push-pull nitrogen bases exhibit a very high basicity. This paper presents an analysis of the exceptional gas-phase basicity, mostly in terms of experimental data, in relation with structure and conjugation of various subfamilies of push-pull nitrogen bases: nitriles, azoles, azines, amidines, guanidines, vinamidines, biguanides, and phosphazenes. The strong basicity of biomolecules containing a push-pull nitrogen substructure, such as bioamines, amino acids, and peptides containing push-pull side chains, nucleobases, and their nucleosides and nucleotides, is also analyzed. Progress and perspectives of experimental determinations of GBs and PAs of highly basic compounds, termed as “superbases”, are presented and benchmarked on the basis of theoretical calculations on existing or hypothetical molecules.

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1,236-Naphthyridine – Wikipedia,
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