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A series of novel phthalazinone-based copolymers with intrinsic microporosity (PHPIMs) was successfully prepared by an aromatic double nucleophilic polycondensation reaction of a designed and synthesized, new rigid and twisty monomer,tetrahydroxyl-phthalazinone (TPHPZ), with 5,5?,6,6?-tetrahydroxy-3,3,3?,3?-tetramethyl-1,10-spirobisindane (TTSBI) and 2,3,5,6-tetrafluoroterephthalonitrile (TFTPN). These copolymers showed excellent solubility in common organic solvents, and were employed to prepared membranes. The gas transportation properties of the resultant membranes were also investigated. The thermal analysis, GPC characterization and 77?K nitrogen adsorption results indicated that all the copolymers exhibited excellent thermal stability, high molecular weight, and high BET surface areas ranging from 693 to 812?m2/g. The gas separation performance of the polymer membranes demonstrated that the ideal selectivity (alpha) of H2/N2, O2/N2, CO2/N2 and CO2/CH4 gas pairs of the obtained PHPIMs exhibited an effective improvement, surpassing the 2008 Robeson plot for the gas pair CO2/CH4 and approaching the 2008 Robeson upper bound for gas pairs of H2/N2 and O2/N2, while accompanying with the decrease of the permeability for the increase of the polymer chain stiffness and the physical aging behaviors.

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1,294-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N288 – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. category: naphthyridine, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 254-60-4, name is 1,8-Diazanaphthalene. In an article£¬Which mentioned a new discovery about 254-60-4

Abstract The electronic structures and photophysical properties of six isomeric Ir(III) complexes with different N-heterocyclic naphthyridine ligands were investigated by density functional theory (DFT) and time dependent DFT (TD-DFT) approach. The radiative transition rates (kr) were determined through calculated the spin-orbital coupling (SOC) matrix elements TmHSOCSn and the energy levels (ESn and ETm). The non-radiative transition rates (knr) were estimated through analysis of the structural distortions, the d-orbital splittings and the energy differences between the S0 and T1 states DeltaE(T1 – S0). As the results, the ESn, the ETm and the energy splittings DeltaES1-Tm and DeltaETm-Tm-1 can be regulated by the position of two nitrogen atoms in naphthyridine ring for studied complexes. Moreover, Ir(III) complex inclusive of quinoxaline heterocyclic ring presents large kr and knr, so its phosphorescence quantum efficiency is difficult up to be 100%. While two Ir(III) complexes bound to quinazoline heterocyclic ring show weakly emissive because of large knr. Notably, the presence of the cinnoline heterocyclic ring in the Ir(III) complex makes singlet-triplet intersystem (ISC) rate and kr fast but knr slow, then leads to its high phosphorescence quantum efficiency.

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1,187-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N181 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of 1,8-Diazanaphthalene, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 254-60-4, Name is 1,8-Diazanaphthalene, molecular formula is C8H6N2

Human telomeric G-quadruplex DNA stabilization has emerged as an exciting novel approach for anticancer drug development. In the present study, we have designed and synthesized three C2-symmetric bisubstituted bisbenzimidazole naphthalenediimide (NDI) ligands, ALI-C3, BBZ-ARO, and BBZ-AROCH2, which stabilize human telomeric G-quadruplex DNA with high affinity. Herein, we have studied the binding affinities and thermodynamic contributions of each of these molecules with G-quadruplex DNA and compared the same to those of the parent NDI analogue, BMSG-SH-3. Results of fluorescence resonance energy transfer and surface plasmon resonance demonstrate that these ligands have a higher affinity for G4-DNA over duplex DNA and induce the formation of a G-quadruplex. The binding equilibrium constants obtained from the microcalorimetry studies of BBZ-ARO, ALI-C3, and BBZ-AROCH2 were 8.47, 6.35, and 3.41 muM, respectively, with h-telo 22-mer quadruplex. These showed 10 and 100 times lower binding affinity with h-telo 12-mer and duplex DNA quadruplexes, respectively. Analysis of the thermodynamic parameters obtained from the microcalorimetry study suggests that interactions were most favorable for BBZ-ARO among all of the synthesized compounds. The DeltaGfree obtained from molecular mechanics Poisson-Boltzmann surface area calculations of molecular dynamics (MD) simulation studies suggest that BBZ-ARO interacted strongly with G4-DNA. MD simulation results showed the highest hydrogen bond occupancy and van der Waals interactions were between the side chains of BBZ-ARO and the DNA grooves. A significant inhibition of telomerase activity (IC50 = 4.56 muM) and induced apoptosis in cancer cell lines by BBZ-ARO suggest that this molecule has the potential to be developed as an anticancer agent.

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1,262-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N256 – PubChem

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The self-assembly into supramolecular polymers is a process driven by reversible non-covalent interactions between monomers, and gives access to materials applications incorporating mechanical, biological, optical or electronic functionalities. Compared to the achievements in precision polymer synthesis via living and controlled covalent polymerization processes, supramolecular chemists have only just learned how to developed strategies that allow similar control over polymer length, (co)monomer sequence and morphology (random, alternating or blocked ordering). This highlight article discusses the unique opportunities that arise when coassembling multicomponent supramolecular polymers, and focusses on four strategies in order to control the polymer architecture, size, stability and its stimuli-responsive properties: (1) end-capping of supramolecular polymers, (2) biomimetic templated polymerization, (3) controlled selectivity and reactivity in supramolecular copolymerization, and (4) living supramolecular polymerization. In contrast to the traditional focus on equilibrium systems, our emphasis is also on the manipulation of self-assembly kinetics of synthetic supramolecular systems.

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1,61-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N55 – PubChem

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The FTIR (4000-400cm-1) and the FT-Raman spectra (4000-50cm-1) of 4-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid are recorded and investigated. The spectra are interpreted using anharmonic frequency computations by VPT2, VSCF and PT2-VSCF methods within DFT/6-311G(d,p) framework. The root mean square (RMS) values indicate that VSCF computed frequencies are in close agreement with the observed frequencies. The combination and overtone bands are also identified in the FTIR spectrum. The intermolecular O-H?O hydrogen bonding interactions are discussed in the dimer structure of the molecule. The magnitudes of the coupling between pair of modes are also computed. The electronic spectra in water and ethanol solvents are analyzed using TD-B3LYP/6-311++G(d,p) level of theory. Molecular electrostatic potential (MEP) and HOMO-LUMO analysis are also performed.

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1,62-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N56 – PubChem

Reference of 254-60-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.254-60-4, Name is 1,8-Diazanaphthalene, molecular formula is C8H6N2. In a Article£¬once mentioned of 254-60-4

The X-ray crystal structure of N-(7-([2-(dimethylamino)ethyl]amino)-1-methyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3- yl)-3,4,5-trimethoxybenzamide, a potential anticancer agent targeting Hsp90, was established. It crystallizes in the triclinic space group P-1 with cell parameters a = 9.3554(4)A, b = 11.4450(5)A, c = 11.5629(4)A, alpha = 87.140(2), beta = 78.8070(19), gamma = 69.2119(19), V = 1135.21(8)A3 and Z = 2. The crystal structure was refined to final values of R1 = 0.0492 and wR2 = 0.1386. An X-ray crystal structure analysis revealed that each molecule features intermolecular N-H¡¤¡¤¡¤N hydrogen bonds to form dimers.

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1,125-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N119 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Application In Synthesis of 1,8-Diazanaphthalene, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 254-60-4

It is an urgent subject to create renewable energy resources such as artificial photosynthetic system and fuel cell free of an environmental pollution, since global warming is closely related to tremendous consumption of fossil fuels to emit carbon dioxide. In this review, we focus on reduction catalyses indispensable for creating new energy systems, especially in the aspects of molecular catalyst. Recent examples of the molecular catalyses for O2, CO2, and H+ reductions are reviewed compared with the characteristics of noble metal catalysts. Molecular aggregates composed of a simple metal complex and a functional polymer can be easily prepared without employing complicated materials such as supra-molecular and hybrid complexes. When using molecular aggregates as a catalyst, the efficient catalysis via an multi-electron transfer reduction by the complex often takes place coupled with the intrinsic characteristics of the polymer employed; moreover, they show unique and active catalysis that cannot be achieved by the corresponding neat complex in a solution or in an electrode-coated state. Typical effects of polymer affecting the efficient molecular catalysis are shown to propose approaches for designing and developing catalysts in molecular level.

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1,37-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N31 – PubChem

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The ruthenium complexes bearing 1,8-naphthyridine (napy) and terpyridine analogous (N,C,N)-tridentate ligands were synthesized and characterized. The reaction of [RuCl2(napy-kappa2,N,N?)(dmso) 2] with 2 equiv of AgPF6 and subsequent addition of LH and CO gave [RuL(napy-kappa2N,N?)(CO)](PF6) n (6a: L = N-methyl-3,5-di(2-pyridyl)-4-pyridyl, n = 2; 6b: L = 2,6-di(2-pyridyl)phenyl, n = 1) via [RuL(napy-kappa2N,N? )(dmso) (PF6)n (5a: L = N-methyl-3,5-di(2-pyridyl)-4-pyridyl, n = 2; 5b: L = 2,6-di(2-pyridyl)phenyl, n = 1). The crystal structures of 5a and 6a show distorted octahedral coordination with the tridentate (N,C,N)-ligand as mer-fashion, two nitrogens of bidentate napy and the sulfur of DMSO (5a) or the carbon of the CO ligand (6a). Detailed experiments for irradiation and variable-temperature 1H NMR studies reveal a fluxional process of the chelated napy ligand in solution.

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1,161-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N155 – PubChem

254-60-4, Name is 1,8-Diazanaphthalene, belongs to naphthyridine compound, is a common compound. Application In Synthesis of 1,8-DiazanaphthaleneIn an article, once mentioned the new application about 254-60-4.

A series of nalidixic acid-based hydrazones and their Au III, PtIV metal complexes have been synthesized and evaluated for their in vitro antimicrobial activity based on dimension of the diameter of inhibition zone formed round the well against a panel of reference strains of microorganisms, including Gram-positive bacteria, Gram-negative bacteria, and fungi Candida albicans and Candida tropicalis. Nalidixic acid hydrazone derivatives were obtained by condensation reaction of nalidixic acid hydrazide with substituted aromatic aldehydes and acetophenone. The complexes of Au III, Pt IV metals with nalidixic acid hydrazone derivatives were synthesized. All compounds have been characterized by elemental analysis, FT-IR,1H NMR and13C NMR spectra. The antimicrobial activity indicated that all ligands and metal complexes showed significant activity of anti-bacterial, antifungal activity comparable to that of parent and standard.

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1,43-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N37 – PubChem

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Protein kinase B (PKB, also known as Akt) plays a critical role in the multiple cellular processes including glucose metabolism, cell growth, survival, apoptosis, transcription, and cell migration. Unregulated activation of protein kinase B is common in a significant fraction of human cancer, making enzyme an exciting new target for cancer therapy. A series of inhibitors with different mechanisms have been found, which is bound to be a positive impact on drug screening and cancer treatment. However, the development of inhibitors targeting PKB has been hampered by lacking of PKB-specific and isoform-specific inhibitors. This article describes the structure and functions of PKB as well as the recent advances in the development and biological evaluation of PKB’s inhibitors. It was focused on the developments of selective small-molecule inhibitors with a well-defined, direct molecular interaction with protein kinase B, expecting to give information to design new inhibitors with high selectivity, bioavailability, and potency

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1,254-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N248 – PubChem