Category: 254-60-4

254-60-4, Name is 1,8-Diazanaphthalene, belongs to naphthyridine compound, is a common compound. Application In Synthesis of 1,8-DiazanaphthaleneIn an article, once mentioned the new application about 254-60-4.

The title compound, C17H13Br2N3O¡¤C4H5NO2, is a co-crystal of N-(7-dibromomethyl-5-methyl-1,8-naphthyridin-2-yl)benzamide and pyrrolidine-2,5-dione (succinimide). The benzamide molecule exhibits pseudo-mirror symmetry, with an r.m.s. deviation of the non-H atoms of 0.09 A (except for the two Br atoms). The angle between the least-squares planes of the two molecules is 26.2 (2). In the crystal, the two molecules are mutually linked by N – H?O and N – H?N hydrogen bonds. The packing is consolidated by C – H?(O,N) hydrogen bonds and pi-pi stacking interactions.

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1,272-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N266 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. name: 1,8-Diazanaphthalene. Introducing a new discovery about 254-60-4, Name is 1,8-Diazanaphthalene

The inhibition effect of three naphthyridine derivatives namely 2-amino-4-(4-methoxyphenyl)-1,8-naphthyridine-3-carbonitrile (ANC-1), 2-amino-4-(4-methylphenyl)-1,8-naphthyridine-3-carbonitrile (ANC-2) and 2-amino-4-(3-nitrophenyl)-1,8-naphthyridine-3-carbonitrile (ANC-3) as corrosion inhibitors for N80 steel in 15% HCl by using gravimetric, electrochemical techniques (EIS and potentiodynamic polarization), SEM, EDX and quantum chemical calculation. The order of inhibition efficiency is ANC-1>ANC-2>ANC-3. Potentiodynamic polarization reveals that these inhibitors are mixed type with predominant cathodic control. Studied inhibitors obey the Langmuir adsorption isotherm. The quantum calculation is in good agreement with experimental results.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.name: 1,8-Diazanaphthalene, you can also check out more blogs about254-60-4

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1,48-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N42 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: 1,8-Diazanaphthalene, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 254-60-4, Name is 1,8-Diazanaphthalene, molecular formula is C8H6N2

This Minireview covers reports on the enantioselective synthesis of alkyl azaarenes since 2014. It deals with the latest achievements on the reactivity of alkyl azaarenes aiming at the preparation of more complex azaarenes containing chiral centers. They rely on the activating properties of the nitrogen atom when opportunely coordinated with a metal complex or Br¡ãnsted acid and possibly containing chiral ligands. In addition, conveniently located electron-withdrawing activating functional groups help increase the reactivity of the azaarenes. The same concepts operate in the case of vinyl azaarenes.

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1,194-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N188 – PubChem

Electric Literature of 254-60-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.254-60-4, Name is 1,8-Diazanaphthalene, molecular formula is C8H6N2. In a Article£¬once mentioned of 254-60-4

Molecular structure of a naphthyridine and pyrazine amine ligand, N2,N7-di (pyrazin-2-yl)-1,8-naphthyri-dine-2,7-diamine (H2dpznda 1) was studied, and a three-dimensional supramolecular network with a double helix chain structure through intermolecular hydrogen bonds and pi-pi interactions between the naphthyridine and pyrazine rings was depicted. Through ligand 1, [Co2 (mu 2-dpznda) 2 (mu 2-CH3OH) 2] (2) was obtained and two ligands coordinate to two Co2+ as tetradentate bridging ligands. Single crystal and magnetism study on 2 revealed that the complex exhibited weak yet significant metal-metal interaction.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 254-60-4

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1,256-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N250 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, COA of Formula: C8H6N2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 254-60-4, Name is 1,8-Diazanaphthalene, molecular formula is C8H6N2

Despite the rapid development of modern methods of cancer treatments, chemotherapy is still one of the most important, and sometimes, the only one method of therapy. The development of cancer treatment methods indicates that search of the new, more effective and safer medicines are necessary. Treatment using common anticancer drugs is associated with their interaction with DNA. Further research on the binding of metal ions and their complexes to DNA resulted from their potential applications as new therapeutic and diagnostic agents. It is well known that mutations in DNA play a significant role in the formation of tumors, however not all of these processes are known. The recognition of binding lanthanide(III) ions or lanthanide(III) complexes to DNA and cleavage DNA via lanthanide(III) complexes are important to understand unknown mutations that lead to cancer and treatment of this disease. The scientists have been undertaking various attempts to interfere the human DNA in order to overcome genetic diseases. Gene therapy could be considered as a kind of scissors that allow to cleavage the DNA in the proper place and insert the corrective gene. Lanthanide(III) ions and their complexes, due to their unique properties, could be widely used as luminescent probes for bioassays and as reagents in optical and magnetic resonance imaging. The luminescence properties of these compounds also have been adopted in medicinal diagnosis. This review will summarize the role of lanthanide(III) ions and their compounds in recent studies on the use of lanthanide(III) complexes to bind, cleavage of DNA also in diagnosis, and monitoring the treatment of cancer disease.

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1,146-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N140 – PubChem

254-60-4, Name is 1,8-Diazanaphthalene, belongs to naphthyridine compound, is a common compound. Quality Control of 1,8-DiazanaphthaleneIn an article, once mentioned the new application about 254-60-4.

Keeping in view the ever growing demand and application of the organic small molecules based sensitive and selective fluorescence detection strategies for the trace metallic ions in the ecosystem, fluids and inside intracellular media, the present literature survey was focused on the recent development on the organic skeleton based fluorescence sensor for the zinc ion as Zn2+ is the second most abundant transition metal after iron in human body. The prominent organic based skeletons introduced during the past three years for zinc detection including azine, ((Z)-N¡ä-(quinolin-2-ylmethylene)furan-2-carbohydrazide), nicotinohydrazide, hydrazone, phenolic cage, 4-methyl-2,6-bis[(E)-(2-(4-phenylthiazol-2-yl)hydrazono)methyl]phenol, bipyridine, N-(quinoline-8-yl)pyridine-2-carboxamide, anthracene, Schiff base, salen, helicene, Carbon Quantum Dots (CDs) func-tionalized with Calix[4]arene, coumarin, diaminomaleonitrile, peptide, hydroxypyrazole, salicylhydrazide were discussed in detail with particular focus on ligand-zinc complexation mechanism, UV-visible and fluorescence investigation, spectral variation, isosbestic emergence, limit of detection, ligand-zinc binding stoichiometry, association/binding constant and applications for intracellular tracing of metallic contamination via confocal fluorescence microscopic studies. Among the several discussed optical probes, rhodamine and fluorescein based material offer appreciable sensitivity, exhibiting drawback of pH sensitivity. Probes based on these ligands triggered ?turn-on? signal even in the absence of metals upon fluctuation in pH e.g., acidic in former case and basic in the latter case. Hydroxypyrazole-based ligands also showed detection signal variation by switching the pH of the solution. Schiff base and bipyridyl scaffold were found to possess good ligation toward the several transition metals. Azole, oxazole, thiazole, thiadiazole, hydrazine carboxamide and hydrazine car-bothiomide are the bioactive molecules exhibiting good cell viability and probes designed by using these central nucleus might be better to invest for intracellular imaging. Symmetrical heterocyclic cage like probe showed better chelation toward several transition metals and it is a good choice for the design and development of sensor for simultaneous detection of several transition metals.

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1,135-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N129 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: 1,8-Diazanaphthalene, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 254-60-4, Name is 1,8-Diazanaphthalene, molecular formula is C8H6N2

A triplex-forming oligonucleotide (TFO) can recognize the homopurine-homopyrimidine sequence in DNA duplexes and inhibit the transcription of targeted mRNAs. Recently, we reported that N-acetyl-2,7-diamino-1,8-naphthyridine (DANac), incorporated into a TFO, has high binding ability and base recognition selectivity for the pyrimidine bases in the purine-rich chain of the DNA duplex at pH 7.4. However, it was found in this study that the difference in the Tm values between the pyrimidine bases and purine bases decreased by more than 4 C at pH 6.0?7.0. To improve the low base recognition selectivity of the TFO, we designed a new artificial base, DAQac, with a quinoline skeleton. The Tm values of the triplexes containing DAQac:T-A or DAQac:C-G were more than 13 C higher than those of the triplexes containing DAQac:A-T or DAQac:G-C at pH 7.4. We also observed that under more acidic conditions (pH 6.0?7.0), the base recognition selectivity of DAQac in a triplex was higher than that of DANac, although the binding ability of DAQac in a triplex was similar to that of DANac. Additionally, we found that DAQac, incorporated into the TFO, could accurately recognize the MeC-G base pair in the hairpin DNA, similar to the C-G base pair.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. name: 1,8-Diazanaphthalene, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 254-60-4, in my other articles.

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1,211-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N205 – PubChem

254-60-4, Name is 1,8-Diazanaphthalene, belongs to naphthyridine compound, is a common compound. Safety of 1,8-DiazanaphthaleneIn an article, once mentioned the new application about 254-60-4.

Human telomeric DNA (hTelo), present at the ends of chromosomes to protect their integrity during cell division, comprises tandem repeats of the sequence d(TTAGGG) which is known to form a G-quadruplex secondary structure. This unique structural formation of DNA is distinct from the well-known helical structure that most genomic DNA is thought to adopt, and has recently gained prominence as a molecular target for new types of anticancer agents. In particular, compounds that can stabilize the intramolecular G-quadruplex formed within the human telomeric DNA sequence can inhibit the activity of the enzyme telomerase which is known to be upregulated in tumor cells and is a major contributor to their immortality. This provides the basis for the discovery and development of small molecules with the potential for selective toxicity toward tumor cells. This review summarizes the various families of small molecules reported in the literature that have telomeric quadruplex stabilizing properties, and assesses the potential for compounds of this type to be developed as novel anticancer therapies. A future perspective is also presented, emphasizing the need for researchers to adopt approaches that will allow the discovery of molecules with more drug-like properties in order to improve the chances of lead molecules reaching the clinic in the next decade.

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1,143-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N137 – PubChem

Application of 254-60-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.254-60-4, Name is 1,8-Diazanaphthalene, molecular formula is C8H6N2. In a Article£¬once mentioned of 254-60-4

The organic crystal 4-aminopyridinium 4-hydroxy benzoate hydrate was grown using slow evaporation method. Various characterization techniques such as single crystal X-ray diffraction, powder X-ray diffraction, FTIR, UV-visible-NIR spectroscopy and thermal analysis (TG-DSC) were employed to assay the structure and properties of the grown crystal. The antimicrobial evaluation of 4-aminopyridinium 4-hydroxy benzoate hydrate crystal was also performed against some bacteria and fungi. The minimum inhibitory concentration (MIC) values of 4-aminopyridinium 4-hydroxy benzoate hydrate were determined for bacterial and fungal strains. The assessment of optimized structure of the molecule and vibrational frequencies were done using DFT/B3LYP method with 6-31 G (d, p) basis set. The stability of the molecule, hyperconjugative interactions, delocalization of charges and intermolecular hydrogen bond were studied by applying natural bond orbital (NBO) analysis. TD-DFT method employing polarizable continuum model (PCM) was used to examine the electronic absorption spectrum. Evaluation of molecular electrostatic potential (MEP), Mulliken population charges and nonlinear optical (NLO) properties were also carried out. In addition, from the optimized geometry, frontier molecular orbitals analysis was executed.

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1,155-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N149 – PubChem

Reference of 254-60-4, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 254-60-4, Name is 1,8-Diazanaphthalene,introducing its new discovery.

Nanometer-range distances are important for restraining the three-dimensional structure and oligomeric assembly of proteins and other biological molecules. Solid-state NMR determination of protein structures typically utilizes 13C-13C and 13C-15N distance restraints, which can only be measured up to ?7 A because of the low gyromagnetic ratios of these nuclear spins. To extend the distance reach of NMR, one can harvest the power of 19F, whose large gyromagnetic ratio in principle allows distances up to 2 nm to be measured. However, 19F possesses large chemical shift anisotropies (CSAs) as well as large isotropic chemical shift dispersions, which pose challenges to dipolar coupling measurements. Here, we demonstrate 19F-19F distance measurements at high magnetic fields under fast magic-angle spinning (MAS) using radiofrequency-driven dipolar recoupling (RFDR). We show that 19F-19F cross-peaks for distances up to 1 nm can be readily observed in two-dimensional 19F-19F correlation spectra using less than 5 ms of RFDR mixing. This efficient 19F-19F dipolar recoupling is achieved using practically accessible MAS frequencies of 15-55 kHz, moderate 19F radio frequency field strengths, and no 1H decoupling. Experiments and simulations show that the fastest polarization transfer for aromatic fluorines with the highest distance accuracy is achieved using either fast MAS (e.g., 60 kHz) with large pulse duty cycles (>50%) or slow MAS with strong 19F pulses. Fast MAS considerably reduces relaxation losses during the RFDR pi-pulse train, making finite-pulse RFDR under fast-MAS the method of choice. Under intermediate MAS frequencies (25-40 kHz) and intermediate pulse duty cycles (15-30%), the 19F CSA tensor orientation has a quantifiable effect on the polarization transfer rate; thus, the RFDR buildup curves encode both distance and orientation information. At fast MAS, the impact of CSA orientation is minimized, allowing pure distance restraints to be extracted. We further investigate how relayed transfer and dipolar truncation in multifluorine environments affect polarization transfer. This fast-MAS 19F RFDR approach is complementary to 19F spin diffusion for distance measurements and will be the method of choice under high-field fast-MAS conditions that are increasingly important for protein structure determination by solid-state NMR.

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1,242-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N236 – PubChem