2689-65-8 | Page 24 of 35 | Heterocyclic Building Blocks-Naphthyridine

Brief introduction of 2689-65-8

Compound(2689-65-8)HPLC of Formula: 2689-65-8 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(5-Iodo-2-furaldehyde), if you are interested, you can check out my other related articles.

HPLC of Formula: 2689-65-8. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-Iodo-2-furaldehyde, is researched, Molecular C5H3IO2, CAS is 2689-65-8, about Potential antimicrobial furans.

Furan derivatives bearing isosteric and isoelec. functional groups in place of a 2-nitro group lacked antibacterial activity, confirming the essential role of the nitro group in activity. Functional groups employed were sulfo, sulfamoyl, carboxyl, methoxycarbonyl, carbamoyl, and cyano. For example, 5-iodo-2-furaldehyde [2689-65-8] reacted with Cu2(CN)2 in DMF to form 5-formyl-2-furonitrile [42061-89-2], which was condensed with semicarbazide [57-56-7], 3-amino-2-oxazolidinone, or 1-aminohydantoin to yield 5-cyano-2-furancarboxaldehyde semicarbazone [42061-90-5], 3-[[(5-cyano-2-furanyl)methylene]amino]-2-oxazolidinone [42978-22-3], and 1-[[(5-cyano-2-furanyl)methylene]amino]-2,4-imidazolidinedione (I) [42061-92-7], resp.

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The origin of a common compound about 2689-65-8

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Infrared spectroscopic study of the condensation reaction of halofurfural with ketones, published in 1965, which mentions a compound: 2689-65-8, Name is 5-Iodo-2-furaldehyde, Molecular C5H3IO2, Application of 2689-65-8.

The reactions of furfuryl iodide (I) and bromide (II) with ketones were investigated. NaOH (3-5 ml., 5%), 0.05 mole halofurfural, and 0.8-3 ml. ketone were added to 20 ml. solvent. The reaction lasted 1-2 hrs. The product was precipitated with 30-50 ml. H2O and dried. The light-yellow oily products were investigated in C2H4Cl2 solutions, the crystalline products in pressed KBr disks. The compositions of the condensation products of I with methyl nonyl ketone, methyl naphthyl ketone, and acetophenone were C16H23O2I, C17H11O2I, and C13H9O2I, resp. The condensations of II with methyl alkyl ketones, where the alkyl group was Et, Pr, Bu, amyl, hexyl, isopropyl, and isobutyl, and with acetophenone and acetylacetone, led to C9H9O2Br, C10H11O2Br, C11H13O2Br, C12H15O2Br, C13H17O2Br, C10H11O2Br, C11H13O2Br, C13H9O2Br, and C10H9O3Br, resp. The ir spectra indicate the functional groups present in the various products.

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Extracurricular laboratory: Synthetic route of 2689-65-8

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Iodo-2-furaldehyde, is researched, Molecular C5H3IO2, CAS is 2689-65-8, about Practical Intermolecular Hydroarylation of Diverse Alkenes via Reductive Heck Coupling, the main research direction is alkene aryl iodide reductive Heck hydroarylation palladium; alkylarene regioselective preparation; palladium reductive Heck hydroarylation catalyst; Heck reaction; alkenes; hydroarylation; palladium; regioselectivity.Recommanded Product: 2689-65-8.

The hydroarylation of alkenes is an attractive approach to construct carbon-carbon (C-C) bonds from abundant and structurally diverse starting materials. A palladium-catalyzed reductive Heck hydroarylation of aliphatic and heteroatom-substituted terminal alkenes and select internal alkenes with an array of (hetero)aryl iodides, is reported. The reaction is anti-Markovnikov selective with terminal alkenes and tolerates a wide variety of functional groups on both the alkene and (hetero)aryl coupling partners. Addnl., applications of this method to complex mol. diversifications are demonstrated. Mechanistic experiments are consistent with a mechanism in which the key alkylpalladium(II) intermediate is intercepted with formate and undergoes a decarboxylation/C-H reductive elimination cascade to afford the saturated product and turn over the cycle.

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Machine Learning in Chemistry about 2689-65-8

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of iodo derivatives of the furan series. 5-Iodofurfural》. Authors are Nazarova, Z. N..The article about the compound:5-Iodo-2-furaldehydecas:2689-65-8,SMILESS:IC1=CC=C(O1)C=O).Recommanded Product: 2689-65-8. Through the article, more information about this compound (cas:2689-65-8) is conveyed.

All 5-bromo or -iodo derivatives of furan lose halogen quant. on standing 48 h. in the dark in HNO3 (d. 1.4) in the presence of AgNO3, followed by heating to 50-60° until N oxide vapor appear; the method can be used for anal. of these compounds Refluxing 35 g. 5-bromofurfural with 3.5 g. KI and 180 mL. AcOH 1 h., followed by dilution with H2O gave 96% crude product, m. 124-6°, which gave 80% pure 5-iodofurfural, m. 127.5-8° (from EtOH); with HNO3 it gives vapor of iodine; oxime, decompose 167-8°; semicarbazone, decompose 199-200°. The aldehyde in 30% NaOH treated with a few drops H2O2 and kept 4 days, then acidified, gave 58.8% 5-iodofurancarboxylic acid, decompose 197-8° (from H2O). The aldehyde heated with Ac2O-AcOK at 145-50°, then boiled with a little H2O 15 min. gave 82.2% 5-iodo-2-furylacrylic acid, decompose 159-60° (from dilute dioxane). The aldehyde condensed with MeNO2 (cf. C.A. 49, 9606b) gave 86% 1-(5-iodo-2-furyl)-2-nitroethylene (I), yellow-orange, m. 112-13° (from EtOH); if the intermediately formed Na salt is filtered directly from the mixture and is carefully decomposed with AcOH after washing with Et2O and MeOH, there is formed the unstable nitro alc., orange-red oil, which after steam distillation gave 80% I, m. 112-13°. The Br analog heated with KI and NaI in AcOH 2 h. on a steam bath gave 82.6% I. Heating 2-(5-bromo-2-furyl)-1-chloro-1-nitroethylene (cf. loc. cit.) with NaI in AcOH 2 h. gave 48.2% 5-iode analog, C6H3BrCINO3, m. 109-9.5° (from EtOH), an irritant which loses iodine on heating with HNO3.

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Let`s talk about compounds: 2689-65-8

When you point to this article, it is believed that you are also very interested in this compound(2689-65-8)Application In Synthesis of 5-Iodo-2-furaldehyde and due to space limitations, I can only present the most important information.

Application In Synthesis of 5-Iodo-2-furaldehyde. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-Iodo-2-furaldehyde, is researched, Molecular C5H3IO2, CAS is 2689-65-8, about Furan derivatives. LV. Kinetics of condensation of 5-nitrofurfuryl sulfones with aldehydes. Author is Knoppova, V.; Jurasek, A.; Kovac, J.; Guttmann, M..

The kinetics of the condensation of I with II (R = H, Me, iodo, Cl, Br, CO2Me NO2) or III (R = H, NO2, Cl, Br, CO2H, CO2Et, Me, MeO, NHAc) [to give, resp., the corresponding (E)-IV or (E)-V, examined in NH4OAc-piperidine at 118° or MeOH-piperidine at 40°, were 2nd order. The log k was linearly related with σp+. The pKa of I and of 5-nitrofurfuryl Me sulfone (VI) were determined and the rates of the condensation of I or VI with III (R = NO2) indicated that steric factors were more important in the condensation than was the sulfone acidity.

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New learning discoveries about 2689-65-8

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Iodo-2-furaldehyde(SMILESS: IC1=CC=C(O1)C=O,cas:2689-65-8) is researched.Related Products of 97739-46-3. The article 《Topoisomerase IIα poisoning and DNA double-strand breaking by chiral ruthenium(II) complexes containing 2-furanyl-imidazo[4,5-f][1,10]phenanthroline derivatives》 in relation to this compound, is published in Dalton Transactions. Let’s take a look at the latest research on this compound (cas:2689-65-8).

Four chiral Ru(II) complexes bearing furan ligands, Δ/Λ-[Ru(bpy)2(pocl)]2+ (Δ/Λ-1) and Δ/Λ-[Ru(bpy)2(poi)]2+ (Δ/Λ-2) (bpy = 2,2′-bipyridine, pocl = 2-(5-chlorofuran-2-yl)imidazo[4,5-f][1,10]phenanthroline, poi = 2-(5-5-iodofuran-2-yl)imidazo[4,5-f][1,10]phenanthroline), were synthesized and characterized. These Ru(II) complexes showed antitumor activities against HeLa, A549, HepG2, HL-60 and K562 tumor cell lines, especially the HL-60 tumor cell line. Moreover, Δ-2 was more active than other complexes accounting for the different cellular uptakes. In addition, Δ-2 could accumulate in the nucleus of HL-60 cells, suggesting that nucleic acids were the cellular target of Δ-2. Topoisomerase inhibition tests in vitro and in living cells confirmed that the four complexes acted as efficient topoisomerase IIα poisons, DNA double-strand breaks had also been observed from neutral single cell gel electrophoresis (comet assay). Δ-2 inhibited the growth of HL-60 cells through the induction of apoptotic cell death, as evidenced by the Alexa Fluor 488 annexin V staining assays. The results demonstrated that Δ-2 acted as a topoisomerase IIα poison and caused DNA double-strand damage that could lead to apoptosis.

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Properties and Exciting Facts About 2689-65-8

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-Iodo-2-furaldehyde, is researched, Molecular C5H3IO2, CAS is 2689-65-8, about Synthesis of Alkyl Indium Reagents by Using Unactivated Alkyl Chlorides and Their Applications in Palladium-Catalyzed Cross-Coupling Reactions with Aryl Halides.HPLC of Formula: 2689-65-8.

An efficient method for the preparation of alkyl indium reagents by using unactivated and cheap alkyl chlorides as substrates in the presence of indium and LiI was developed. The thus-formed alkyl indium species effectively underwent palladium-catalyzed cross-coupling reactions with aryl halides with wide functional group tolerance.

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The effect of the change of synthetic route on the product 2689-65-8

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Iodo-2-furaldehyde, is researched, Molecular C5H3IO2, CAS is 2689-65-8, about Synthesis and spectral properties of 2-(5-R-2-furylmethylene)-3-oxobutanenitriles, the main research direction is furylmethyleneoxobutanenitrile; butanenitrile furylmethylene; condensation furaldehyde aminobutenenitrile; substituent effect conjugation furylethylene system; LFER furylmethyleneoxobutanenitrile; structure property furylmethyleneoxobutanenitrile.Safety of 5-Iodo-2-furaldehyde.

Substituted 2-(5-R-2-furylmethylene)-3-oxobutanenitriles I (R = H, halo, Ph, etc.) were obtained by condensation of the corresponding 5-R-2-furaldehydes II with 3-amino-2-butenenitrile in acid medium. Relation between the structure and spectral properties (NMR, IR, UV, MS) is presented and the influence of substituents in position 5 of the furan ring on the conjugated 2-furylethylene system is discussed.

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You Should Know Something about 2689-65-8

Kalinin, V. N.; Pashchenko, D. N.; Phan Minh She published the article 《Palladium-catalyzed synthesis of 4-heteroaryl and 4-alkynyl-substituted sydnones. 5-Oxido-3-phenyl-1,2,3-oxadiazol-3-ium-4-ylzinc chloride》. Keywords: palladium catalyzed coupling oxidophenyloxadiazoliumylcopper heteroaryl iodide; alkynyl bromide palladium catalyzed coupling oxidophenyloxadiazoliumylcopper; oxidophenyloxadiazoliumylzinc chloride preparation reactivity; sydnone heteroaryl alkynyl.They researched the compound: 5-Iodo-2-furaldehyde( cas:2689-65-8 ).Safety of 5-Iodo-2-furaldehyde. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2689-65-8) here.

A general method is suggested for the synthesis of 4-heteroaryl- and 4-alkynyl-3-Ph sydnones by palladium(0)-catalyzed cross-coupling of 5-oxido-3-phenyl-1,2,3-oxadiazol-3-ium-4-ylcopper (I, R = Cu) with heteroaryl iodides and alkynyl bromides. Thus, I (R = H) was treated sequentially with BuLi, CuBr, and then 2-iodopyridine and Pd(PPh3)4 in THF-C6H6 to give 85% I (R = 2-pyridyl). 5-Oxido-3-phenyl-1,2,3-oxadiazol-3-ium-4-ylzinc chloride (I, R = ZnCl) was synthesized and found to be significantly less reactive than I (R = Cu) and was successfully coupled only with p-iodonitrobenzene and β-bromostyrene.

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Chen, Bing-Zhi; Zhi, Man-Ling; Wang, Chuang-Xin; Chu, Xue-Qiang; Shen, Zhi-Liang; Loh, Teck-Peng published the article 《Synthesis of Alkyl Indium Reagents by Using Unactivated Alkyl Chlorides and Their Applications in Palladium-Catalyzed Cross-Coupling Reactions with Aryl Halides》. Keywords: alkyl chloride substrate alkylindium reagent; palladium catalyzed cross coupling aryl halide alkylindium.They researched the compound: 5-Iodo-2-furaldehyde( cas:2689-65-8 ).Application of 2689-65-8. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2689-65-8) here.

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