Category: 5089-22-5

Synthetic Route of 5089-22-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 5089-22-5, Name is 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene, SMILES is C1(C2=NC3=CC=CC=C3O2)=C4C=CC=CC4=C(C5=NC6=CC=CC=C6O5)C=C1, belongs to naphthyridines compound. In a article, author is Cheng, Yu, introduce new discover of the category.

Structure-based optimization and derivatization of 2-substituted quinolone-based non-nucleoside HCV NS5B inhibitors with submicromolar cellular replicon potency

HCV NS5B polymerase is an attractive and validated target for anti-HCV therapy. Starting from our previously identified 2-aryl quinolones as novel non-nucleoside NS5B polymerase inhibitors, structure-based optimization furnished 2-alkyl-N-benzyl quinolones with improved antiviral potency by employing privileged fragment hybridization strategy. The N-(4-chlorobenzyl)-2-(methoxymethyl) quinolone derivative 5f proved to be the best compound of this series, exhibiting a selective sub-micromolar antiviral effect (EC50 = 0.4 mu M, SI = 10.8) in Huh7.5.1 cells carrying a HCV genotype 2a. Considering the undesirable pharmacokinetic property of the highly substituted quinolones, a novel chemotype of 1,6-naphthyridine-4,5-diones were evolved via scaffold hopping, affording brand new structure HCV inhibitors with compound 6h (EC50 (gt2a) = 2.5 mu M, SI = 7.2) as a promising hit. Molecular modeling studies suggest that both of 2-alkyl quinolones and 1,6-naphthyridine-4,5-diones function as HCV NS5B thumb pocket II inhibitors. (C) 2016 Elsevier Ltd. All rights reserved.

Synthetic Route of 5089-22-5, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 5089-22-5.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 5089-22-5, Name is 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene, molecular formula is C24H14N2O2. In an article, author is Dey, Swapan,once mentioned of 5089-22-5, Product Details of 5089-22-5.

Naphthyridine based fluorescent receptors for the recognition of uric acid

Naphthyridine based fluorogenic receptors (R1, R2, R3 and R4) have been synthesised for the recognition of uric acid (UA). The receptors are very useful for potential applications arising from complexation reactions as demonstrated by H-1 NMR, UV-vis and fluorescence studies. The association constants (K-a) between the receptors and UA have been reported using UV and fluorescence techniques. The minimisation energy calculations and molecular modelling studies for the host-guest assemblies have been discussed in this context.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 5089-22-5, Name is 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene, SMILES is C1(C2=NC3=CC=CC=C3O2)=C4C=CC=CC4=C(C5=NC6=CC=CC=C6O5)C=C1, in an article , author is Abu-Melha, Sraa, once mentioned of 5089-22-5, Safety of 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene.

Synthesis and Biological Evaluation of Some Novel 1,8-Naphthyridine Derivatives

A series of substituted 1,8-naphthyridine derivatives was synthesized to be used as cytotoxic and antioxidant agents by applying 1,4-dihydro-4-oxo-1,8-naphthyridine-3-carbohydrazide (1) as the starting material. Compound 1 was reacted with different reagents to afford the corresponding 3-heterarylcarbonyl-1,8-naphthyridine derivatives 3-19 which were tested for their in vitro cytotoxicity against Ehrlich Ascites Carcinoma, and antioxidant activity. Compound 15 showed the best cytotoxicity and antioxidant activity.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Synthetic Route of 5089-22-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 5089-22-5, Name is 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene, SMILES is C1(C2=NC3=CC=CC=C3O2)=C4C=CC=CC4=C(C5=NC6=CC=CC=C6O5)C=C1, belongs to naphthyridines compound. In a article, author is Javier Perez-Areales, Francisco, introduce new discover of the category.

Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids

Aim: Simultaneous modulation of several key targets of the pathological network of Alzheimer’s disease (AD) is being increasingly pursued as a promising option to fill the critical gap of efficacious drugs against this condition. Materials & methods: A short series of compounds purported to hit multiple targets of relevance in AD has been designed, on the basis of their distinct basicities estimated from high-level quantum mechanical computations, synthesized, and subjected to assays of inhibition of cholinesterases, BACE-1, and A beta 42 and tau aggregation, of antioxidant activity, and of brain permeation. Results: Using, as a template, a lead rhein-huprine hybrid with an interesting multitarget profile, we have developed second-generation compounds, designed by the modification of the huprine aromatic ring. Replacement by [1,8]-naphthyridine or thieno[3,2-e] pyridine systems resulted in decreased, although still potent, acetylcholinesterase or BACE-1 inhibitory activities, which are more balanced relative to their A beta 42 and tau antiaggregating and antioxidant activities. Conclusion: Second-generation naphthyridine-and thienopyridine-based rhein-huprine hybrids emerge as interesting brain permeable compounds that hit several crucial pathogenic factors of AD.

Synthetic Route of 5089-22-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 5089-22-5.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

5089-22-5, Name is 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene, molecular formula is C24H14N2O2, Product Details of 5089-22-5, belongs to naphthyridines compound, is a common compound. In a patnet, author is Tarasov, Andrii V., once mentioned the new application about 5089-22-5.

10-Methoxybenzo[g]imidazo[1,2-a][1,8]naphthyridine-4-carbonitrile

In the title compound, C16H10N4O, both the methoxy and nitrile substituents lie in the plane defined by the benzo[g]imidazo[1,2-a]-1,8-naphthyridine ring system, resulting in a nearly planar geometry for the entire molecule (r.m.s. deviation of the non-H atoms from the mean plane is 0.044 angstrom). In the solid-state, the molecules form a three-dimensional polymer through intermolecular C-H center dot center dot center dot N and C-H center dot center dot center dot O hydrogen bonds. In addition, the packing mode results in stabilizing pi-pi stacking interactions between the asymmetric units.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 5089-22-5 help many people in the next few years. Product Details of 5089-22-5.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

5089-22-5, Name is 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene, molecular formula is C24H14N2O2, Recommanded Product: 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene, belongs to naphthyridines compound, is a common compound. In a patnet, author is Defaux, Julien, once mentioned the new application about 5089-22-5.

Discovery of 7-Aryl-Substituted(1,5-Naphthyridin-4-yl) ureas as Aurora Kinase Inhibitors

As part of our research projects to identify new chemical entities of biological interest, we developed a synthetic approach and the biological evaluation of (7-aryl-1,5-naphthyridin-4-yl)ureas as a novel class of Aurora kinase inhibitors for the treatment of malignant diseases based on pathological cell proliferation. 1,5-Naphthyridine derivatives showed excellent inhibitory activities toward Aurora kinases A and B, and the most active compound, 1-cyclopropyl-3-[7-(1-methyl-1H-pyrazol-4-yl)-1,5-naphthyridin-4-yl]urea (49), displayed IC50 values of 13 and 107nM against Aurora kinases A and B, respectively. In addition, the selectivity toward a panel of seven cancer-related protein kinases was highlighted. In vitro ADME properties were also determined in order to rationalize the difficulties in correlating antiproliferative activity with Aurora kinase inhibition. Finally, the good safety profile of these compounds imparts promising potential for their further development as anticancer agents.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 5089-22-5 help many people in the next few years. Recommanded Product: 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Reference of 5089-22-5, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 5089-22-5, Name is 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene, SMILES is C1(C2=NC3=CC=CC=C3O2)=C4C=CC=CC4=C(C5=NC6=CC=CC=C6O5)C=C1, belongs to naphthyridines compound. In a article, author is Oyama, Dai, introduce new discover of the category.

Reversible Intramolecular Cyclization in Ruthenium Complexes Induced by Ligand-centered One-electron Transfer on Bidentate Naphthyridine: An Important Intermediate for Both Metal- and Organo-Hydride Species

Two types of dicarbonykuthenium(II) complexes bearing the unsymmetrical bidentate ligand 2-(2-pyridy1)-1,8-naphthyridine were prepared. The complexes undergo irreversible ligand-localized one-electron reduction to form redox-induced metal-lacyclization between the bidentate naphthyridyl ligand and the terminal CO ligand located nearby. Chemical reductions using NaBH4 were also performed to isolate the reaction products; the formation of both a metal hydride (Ru-H) and an organo hydride (C-H) species was confirmed.

Reference of 5089-22-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 5089-22-5 is helpful to your research.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 5089-22-5, Name is 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene, SMILES is C1(C2=NC3=CC=CC=C3O2)=C4C=CC=CC4=C(C5=NC6=CC=CC=C6O5)C=C1, belongs to naphthyridines compound. In a document, author is Manera, Clementina, introduce the new discover, Safety of 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene.

New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity

Several recent studies suggest that selective CB2 receptor agonists may represent a valid pharmacological approach in the treatment of various diseases due to the absence of relevant psychoactive side effect. In this study, we synthesized and tested a series of new quinoline-2( 1H)-one- and 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine derivatives characterized by a 4-methylcyclohexylamido substituent in position 3 of the heterocyclic nucleus with high CB2 receptor affinity and selectivity. Two compounds showing the best binding and selectivity profile behaved as a full agonist and a partial agonist at the CB2 receptor and induced a concentration-dependent decrease of cell viability on LNCaP, a prostatic cancer cell line expressing CB2 receptor. Moreover considering that the CB2 receptor is mainly expressed in cells and organs of the immune system, the same compounds were studied for their potential immune-modulatory and anti-inflammatory effects in activated lymphocytes isolated from healthy controls and multiple sclerosis (MS) patients. (C) 2015 Published by Elsevier Masson SAS.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 5089-22-5 is helpful to your research. Safety of 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Let¡¯s face it, organic chemistry can seem difficult to learn, Category: naphthyridines, Especially from a beginner¡¯s point of view. Like 5089-22-5, Name is 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene, molecular formula is naphthyridines, belongs to naphthyridines compound. In a document, author is Kandepedu, Nishanth, introducing its new discovery.

Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria

A novel 2,8-disubstituted-1,5-naphthyridine hit compound stemming from the open access Medicines for Malaria Venture Pathogen Box formed a basis for a hit-to-lead medicinal chemistry program. Structure-activity relationship investigations resulted in compounds with potent antiplasmodial activity against both chloroquine sensitive (NF54) and multidrug resistant (K1) strains of the human malaria parasite Plasmodium falciparum. In the humanized P. falciparum mouse efficacy model, one of the frontrunner compounds showed in vivo efficacy at an oral dose of 4 X 50 mg.g(-1). In vitro mode-of-action studies revealed Plasmodium falciparum phosphatidylinositol-4-kinase as the target.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem