Category: 88847-89-6

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 88847-89-6, Name is 2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione, formurla is C10H13N5O5. In a document, author is Naik, T. R. Ravikumar, introducing its new discovery. Computed Properties of C10H13N5O5.

Synthesis, DNA Binding, Docking and Photoclevage Studies of Novel Benzo[b][1,8]naphthyridines

The synthesis and docking studies of novel benzo[b][1,8] naphthyridines are described. The docking studies show that the derivatives prefer to bind the AT-rich region of double stranded DNA (ds-DNA). The maximum binding energy -7.16 (kcal/mol) was observed for benzo[b][1,8]naphthyridine-5-thiol 5a and it is a better candidate as an enantioselective binder to ds-DNA than the other derivatives of benzo[b][1,8] naphthyridines. When photoirradiated at 365 nm, benzo[1,8]-naphthyridines have been found to promote the photocleavage of plasmid pUC19 DNA.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 88847-89-6 help many people in the next few years. Computed Properties of C10H13N5O5.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Synthetic Route of 88847-89-6, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 88847-89-6, Name is 2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione, SMILES is O=C1N=C(N)NC2=C1NC(N2[C@@H]3O[C@H](CO)[C@@H](O)C3)=O, belongs to naphthyridines compound. In a article, author is Mohamed, S. F., introduce new discover of the category.

Synthesis and Antitumor Activity against HepG-2, PC-3, and HCT-116 Cells of Some Naphthyridine and Pyranopyridinecarbonitrile Derivatives

A series of substituted and fused heterocyclic derivatives 2-17 were synthesized using 3,5-bis(4-methoxybenzylidene)-1-propylpiperidin-4-one (1) as starting material. Treatment of 1 with malononitrile or semicarbazide afforded compounds 2 and 3, respectively. Condensation of 1 with ethyl cyanoacetate afforded naphthyridine-3-carbonitrile derivative 4, which reacted with phosphorus pentachloride and phosphoryl chloride to give chloro derivative 5. Treatment of 5 with thiosemicarbazide afforded compound 6. The reaction of 1 with malononitrile gave cyano aminopyrane derivative 7 which was condensed with pyromellitic dianhydride, phthalic anhydride, succinic anhydride, or morpholine in glacial acetic acid to obtain imide derivatives 8-11. Additionally, the reaction of 7 with aromatic aldehydes gave derivatives 12a-12c. Acetylation of 7 with acetic anhydride in boiling acetic acid gave N-acetyl derivative 13 which was cyclized to pyridine derivative 14 by refluxing in dioxane in the presence of triethylamine. Treatment of 7 with hydrazine hydrate gave pyrazolo derivative 15. Finally, the reaction of 7 with triethyl orthoformate in the presence of acetic anhydride gave formimidate 16 which was treated with hydrazine hydrate to form N-amino derivative 17. Some of the synthesized compounds were examined in vitro for their antitumor activity against HepG-2, PC-3, and HCT-116 human carcinoma cell lines using MTT assay.

Synthetic Route of 88847-89-6, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 88847-89-6 is helpful to your research.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 88847-89-6, Name is 2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione, molecular formula is C10H13N5O5. In an article, author is Yao, Denghui,once mentioned of 88847-89-6, Recommanded Product: 88847-89-6.

A new fluorescent enhancement chemosensor for Al3+ and Fe3+ based on naphthyridine and benzothiazole groups

A novel and easily synthesized compound, N-(2-(2-benzothiazol-2-yl)vinyl-4-methyl-1,8-naphthyrine-7-yl)acetamide (1) based on naphthyridine and benzothiazole group, has been developed as a turn-on fluorescent chemosensor for Al3+ and Fe3+ simultaneously. The absorbance and fluorescent intensities of 1 increased linearly in aqueous solution upon the interaction of 1 with Al3+ or Fe3+. The other co-existing metal ions have no obvious effect on the detection. The Job’s plot and the ESI mass spectra indicated the formation of 1:1 complex between 1 and Al3+ or Fe3+. The sensing mechanism was proposed according to the Job’s plot, ESI mass spectra, H-1 NMR spectra, and density functional theory (DFT) calculation. The properties of the model compound N-(2-((2-methylbenzothiazol-6-ylimino)methyl)-4-methyl-1,8-naphthyridin-7-yflacetamide (2), which was designed and synthesized in order to prove the sensing mechanism, also verified the proposed sensing mechanism. (C) 2017 Elsevier B.V. All rights reserved.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 88847-89-6, Name is 2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione, formurla is C10H13N5O5. In a document, author is Dong, Fang, introducing its new discovery. Name: 2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione.

Synthesis of Benzo[4,5]imidazo[1,2-a]naphthyridine and Benzo[4,5]imidazo[2,1-a]isoquinoline Derivatives Catalyzed by CuI/L-Proline

The benzo[4,5]imidazo[1,2-a]naphthyridines and benzo[4,5]imidazo[2,1-a]isoq-uino lines were obtained via a one-pot domino reaction of 2-(2-bromophenyl)-1H-benzo[d]imidazoles and cyclic 1,3-dicarbonyl compounds in good yields. This copper-catalyzed procedure provided an efficient method for the synthesis of fused pentacyclic heterocycles containing a alpha-arylation of carbonyl reaction.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 88847-89-6 help many people in the next few years. Name: 2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Synthetic Route of 88847-89-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 88847-89-6, Name is 2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione, SMILES is O=C1N=C(N)NC2=C1NC(N2[C@@H]3O[C@H](CO)[C@@H](O)C3)=O, belongs to naphthyridines compound. In a article, author is Bhambi, Dinesh, introduce new discover of the category.

Synthesis and antimicrobial evaluation of some alkoxyphthalimide derivatives of naphthyridine

5-(4-Substitutedphenyl)-8,8-dimethyl-5,8,9,10-tetrahydrobenzo[b][1,8]naphthyridin-7H-one 1a-e have been converted to their N-substituted alkoxyphthalamide derivatives using two alternative pathways. In route one, 1a-e are treated with formalin (37%) to yield 5-(4-substitutedphenyl)-10-(hydroxymethyl)-8,8-dimethyl-5,8,9,10-tetrahydrobenzo[b][1,8]naphthyriding-6-7H-one 2a-e, which is further changed to corresponding chloro derivatives 3a-e by the treatment with thionyl chloride. Condensation of 3a-e with N-hydroxyphthalimide furnished the final compounds 2-{[5-(4-substitutedphenyl)-8,8-dimethyl-6-oxo-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridin-10-5H-yl]mehtoxy}phthalimide 4a-e. In another route, 1a-e is directly condensed with omega-bromoalkoxyphthalimide to yield Higher homologues of 4a-e i.e. 2-{2-[5-(4-substituted phenyl)-8,8-dimethyl-6-oxo-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyriding-10-5H-yl]ehtody} phthalimide derivatives 5a-e. Structures of all the synthesized compounds have been established on the basis of elemental analysis and spectral studies. All the synthesized compounds have been screened for antibacterial and antifungal activities.

Synthetic Route of 88847-89-6, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 88847-89-6.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, Application In Synthesis of 2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione, begins with the direct observation of nature¡ª in this case, of matter.88847-89-6, Name is 2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione, SMILES is O=C1N=C(N)NC2=C1NC(N2[C@@H]3O[C@H](CO)[C@@H](O)C3)=O, belongs to naphthyridines compound. In a document, author is Wazzan, Nuha, introduce the new discover.

DFT calculations of the tautomerization and NW properties of 5-amino-7-(pyrrolidin-1-y1)-2,4,4-trimethy1-1,4-dihydro-1,6-naphthyridine-8-carbonitrile (APNC)

Amine-imine tautomerization in 5-amino-7-(pyrrolidin-1-y1)-2,4,4-trimethy1-1,4-dihydro-1,6-naphthyridine-8-carbonitrile (APNC) has been studied using the B3LYP, CAM-B3LYP and wB97XD with 6-311++G(d,p) basis set. Optimum molecular geometries, electronic properties, energetics and electronic densities of these systems have been discussed and compared with the available experimental data. Investigation reveals that one tautomer (the amine tautomer) dominates the gas phase. The photochromic properties of APNC and its two imine tautomers have been studied at the elected DFT-functionals and basis set. The interconversion Al to 12/13 is predicted to occur photochemically. The NLO properties were also evaluated and discussed. (C) 2017 Elsevier B.V. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 88847-89-6. Application In Synthesis of 2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Electric Literature of 88847-89-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 88847-89-6, Name is 2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione, SMILES is O=C1N=C(N)NC2=C1NC(N2[C@@H]3O[C@H](CO)[C@@H](O)C3)=O, belongs to naphthyridines compound. In a article, author is Takahashi, Nobuaki, introduce new discover of the category.

Development of an anti-hepatitis B virus (HBV) agent through the structure-activity relationship of the interferon-like small compound CDM-3008

Hepatitis B, a viral infectious disease caused by hepatitis B virus (HBV), is a life-threatening disease that leads liver cirrhosis and liver cancer. Because the current treatments for HBV, such as an interferon (IFN) formulation or nucleoside/nucleotide analogues, are not sufficient, the development of a more effective agent for HBV is urgent required. CDM-3008 (1, 2-(2,4-bis(trifluoromethyl)imidazo[1,2-alpha][1,8]naphthyridin-8-yl)-1,3,4-oxadiazole) (RO8191)) is a small molecule with an imidazo[1,2-alpha][1,8] naphthyridine scaffold that shows anti-HCV activity with an IFN-like effect. Here, we report that 1 was also effective for HBV, although the solubility and metabolic stability were insufficient for clinical use. Through the structure-activity relationship (SAR), we discovered that CDM-3032 (11, N-(piperidine-4-yl)-2,4-bis(trifluoromethyl)imidazo[1,2-alpha][1,8]naphthyridine-8-carboxamide hydrochloride) was more soluble than 1 (> 30 mg/mL for 11 versus 0.92 mg/mL for 1). In addition, the half-life period of 11 was dramatically improved in both mouse and human hepatic microsomes (T1/2,> 120 min versus 58.2 min in mouse, and > 120 min versus 34.1 min in human, for 11 and 1, respectively).

Electric Literature of 88847-89-6, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 88847-89-6 is helpful to your research.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Related Products of 88847-89-6, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 88847-89-6, Name is 2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione, SMILES is O=C1N=C(N)NC2=C1NC(N2[C@@H]3O[C@H](CO)[C@@H](O)C3)=O, belongs to naphthyridines compound. In a article, author is Wall, Richard J., introduce new discover of the category.

Antitrypanosomal 8-Hydroxy-Naphthyridnes Are Chelators of Divalent Transition Metals

The lack of information regarding the mechanisms of action (MoA) or specific molecular targets of phenotypically active compounds can prove a barrier to their development as chemotherapeutic agents. Here, we report the results of our orthogonal genetic, molecular, and biochemical studies to determine the MoA of a novel 7-substituted 8-hydroxy-1,6-naphthyridine (8-HNT) series that displays promising activity against Trypanosoma brucei and Leishmania donovani. High-throughput loss-of-function genetic screens in T. brucei highlighted two probable zinc transporters associated with resistance to these compounds. These transporters localized to the parasite Golgi apparatus. Directed by these findings, the role of zinc and other divalent cations in the MoA of these compounds was investigated. 8-HNT compounds were found to directly deplete intracellular levels of Zn2+ while the addition of exogenous Zn2+ and Fe2+ reduced the potency of compounds from this series. Detailed biochemical analyses confirmed that 8-HNT compounds bind directly to a number of divalent cations, predominantly Zn2+ , Fe2+ and Cu2+ forming 2:1 complexes with one of these cations. Collectively, our studies demonstrate transition metal depletion, due to chelation, as the MoA of the 8-HNT series of compounds. Strategies to improve the selectivity of 8-HNT compounds are discussed.

Related Products of 88847-89-6, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 88847-89-6 is helpful to your research.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem