Category: naphthyridine

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 16710-11-5, is researched, SMILESS is CSC1=NC(O)=NC(C)=C1, Molecular C6H8N2OSJournal, Russian Journal of General Chemistry called 4-arylamino-2-(2-acetoxyethyl)amino-6-methylpyrimidines: Synthesis, deacetylation, and biological activity, Author is Erkin, A. V.; Krutikov, V. I., the main research direction is ethanolamine acetate arylaminopyrimidinyl tuberculostatic preparation; pyrimidinediamine acetoxyethyl aryl tuberculostatic preparation; deacetylation acetoxyethylaminopyrimidine.Application In Synthesis of 4-Methyl-6-(methylthio)pyrimidin-2-ol.

The reaction of 2-(2-acetoxyethyl)amino-4-chloro-6-methylpyrimidine with aromatic amines leads to a series of 4-arylamino-2-(2-acetoxyethyl)amino-6-methylpyrimidines. Deacetylation of these compounds proceeds in both acidic and basic media. Most of the (arylamino)pyrimidines obtained exhibit a pronounced antituberculous effect.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Organic Letters called Palladium-Catalyzed Arylation of Cyclopropanes via Directing Group-Mediated C(sp3)-H Bond Activation To Construct Quaternary Carbon Centers: Synthesis of cis- and trans-1,1,2-Trisubstituted Chiral Cyclopropanes, Author is Hoshiya, Naoyuki; Kobayashi, Takaaki; Arisawa, Mitsuhiro; Shuto, Satoshi, which mentions a compound: 2689-65-8, SMILESS is IC1=CC=C(O1)C=O, Molecular C5H3IO2, Formula: C5H3IO2.

Pd(II)-catalyzed tertiary C(sp3)-H arylation of cyclopropanes via directing group-mediated C-H activation for the construction of a chiral quaternary carbon center on cyclopropanes using aryl iodides as a coupling partner is reported. The arylation had a wide substrate scope and good functional group tolerance, including heteroaryl iodides, to provide various chiral arylcyclopropanes with the cis- and trans-1,1,2-trisubstituted structures.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Recommanded Product: 5-Iodo-2-furaldehyde. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-Iodo-2-furaldehyde, is researched, Molecular C5H3IO2, CAS is 2689-65-8, about Palladium-Catalyzed Cross-Coupling of Indium Homoenolate with Aryl Halide with Wide Functional Group Compatibility. Author is Shen, Zhi-Liang; Lai, Yin-Chang; Wong, Colin Hong An; Goh, Kelvin Kau Kiat; Yang, Yong-Sheng; Cheong, Hao-Lun; Loh, Teck-Peng.

An efficient palladium-catalyzed cross-coupling of indium homoenolate with aryl halide is described. The reactions proceeded efficiently in DMA at 100 °C to afford the desired products of β-aryl ketones in moderate to good yields. Various important functional groups including ketone, ester, aldehyde, nitrile, hydroxide, and nitro groups can be well tolerated in the protocol.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Naphthyridine chemistry. V. One-step synthesis of 1,8-naphthyridines》. Authors are Paudler, William W.; Kress, Thomas J..The article about the compound:4-Methyl-1,8-naphthyridinecas:1569-17-1,SMILESS:CC1=C2C=CC=NC2=NC=C1).Safety of 4-Methyl-1,8-naphthyridine. Through the article, more information about this compound (cas:1569-17-1) is conveyed.

cf. CA 66, 6881q; 65, 16955a; 64, 5057c. 2-Aminopyridine treated with Utermohlen’s “”sulfo-mix”” (CA 38, 9735) and glycerol gave 30% 1,8-naphthyridine. Similarly were prepared 2-methyl-, 4-methyl-, and 2,4-dimethyl-1,8-naphthyridines (I,II, and III). N.M.R. spectra data are given for the compounds

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Tlekhusezh, M. A.; Badovskaya, L. A.; Tyukhteneva, Z. I. published an article about the compound: 5-Iodo-2-furaldehyde( cas:2689-65-8,SMILESS:IC1=CC=C(O1)C=O ).SDS of cas: 2689-65-8. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:2689-65-8) through the article.

The reactions of HOCH2CH(NHR)CH2CONHR (R = benzyl, heptyl) with 5-iodofurfural, Cl3CCOOEt, SOCl2, and di-Et oxalate were examined The products included oxazolidines I and II (R = benzyl, heptyl), oxathiazolidine oxide III, and morpholinediones IV (same R). I and III showed antibacterial and antifungal activity.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2689-65-8, is researched, Molecular C5H3IO2, about Study of copper, nickel, and zinc electroplating in the presence of some furaldehydes, the main research direction is copper electroplating furaldehyde structure; zinc electroplating furaldehyde structure; nickel electroplating furaldehyde structure; substituent constant furaldehyde electroplating.Recommanded Product: 5-Iodo-2-furaldehyde.

On the basis of the linearity principle of free energies, a quant. evaluation was made of the effect of the structure of furfural derivatives (I; R = H, Cl, I, Br, CHO, Ph, Me, OMe, Et2N, Me2N) on the kinetics of electroplating of Cu, Ni, and Zn. A correlation was established between electrochem., adsorption,and spectral characteristics of the studied furaldehydes and the substituent constants of their mols.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

COA of Formula: C5H3IO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Iodo-2-furaldehyde, is researched, Molecular C5H3IO2, CAS is 2689-65-8, about A new approach to furan-containing macrolactones. Author is Schmidt, Christoph Q.; Messmer, Ruth; Bracher, Franz; Krauss, Juergen.

Furan and THF heterocycles are part of many natural products, like the Galerucella pheromone, furano epothilones, bipinnatin, and amphidinolides. This paper describes a short and efficient synthetic approach to furan-containing macrolactones in 4 steps, including as key steps a Sonogashira reaction and an olefin metathesis. The resulting compounds were tested at the National Cancer Institute for their cytotoxicity, but did not exhibit significant cytotoxicity in the human tumor cell line screen.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Halogen-substituted products of furfural, published in 1933, which mentions a compound: 2689-65-8, Name is 5-Iodo-2-furaldehyde, Molecular C5H3IO2, Synthetic Route of C5H3IO2.

Furfural diacetate (I) and Br in CHCl3 give 10% of sym-bromofurfural (2-bromo-5-formylfuran), b16 112°, m. 85°; PhNH2 in 50% AcOH gives a characteristic orange-red color; oxime, m. 101°; semicarbazone, m. 215° (corrected, decomposition); phenylhydrazone, m. 80-5°. The di-Et acetal and diacetate could not be prepared Concentrated EtOH-KOH gives bromopyromucic acid. Improved directions are given for the preparation of tetraiodofuran (67% yield). I in AcOH and Hg(OAc)2 give 82% of a trimercuriacetate compound, containing free Hg(OAc)2 which cannot be removed without decomposition of the Hg compound With 0.35% EtOH-HCl there results 86% of the trimercurichloride, which reacts with I in Et2O to give, among other products, sym-iodofurfural, m. 110°.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Infrared spectroscopic study of the condensation reaction of halofurfural with ketones》. Authors are Usmanov, Z.; Tadzhieva, M. A..The article about the compound:5-Iodo-2-furaldehydecas:2689-65-8,SMILESS:IC1=CC=C(O1)C=O).COA of Formula: C5H3IO2. Through the article, more information about this compound (cas:2689-65-8) is conveyed.

The reactions of furfuryl iodide (I) and bromide (II) with ketones were investigated. NaOH (3-5 ml., 5%), 0.05 mole halofurfural, and 0.8-3 ml. ketone were added to 20 ml. solvent. The reaction lasted 1-2 hrs. The product was precipitated with 30-50 ml. H2O and dried. The light-yellow oily products were investigated in C2H4Cl2 solutions, the crystalline products in pressed KBr disks. The compositions of the condensation products of I with methyl nonyl ketone, methyl naphthyl ketone, and acetophenone were C16H23O2I, C17H11O2I, and C13H9O2I, resp. The condensations of II with methyl alkyl ketones, where the alkyl group was Et, Pr, Bu, amyl, hexyl, isopropyl, and isobutyl, and with acetophenone and acetylacetone, led to C9H9O2Br, C10H11O2Br, C11H13O2Br, C12H15O2Br, C13H17O2Br, C10H11O2Br, C11H13O2Br, C13H9O2Br, and C10H9O3Br, resp. The ir spectra indicate the functional groups present in the various products.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Iodo-2-furaldehyde( cas:2689-65-8 ) is researched.Application of 2689-65-8.Chen, Yi-Hung; Knochel, Paul published the article 《Preparation of Aryl and heteroaryl indium(III) reagents by the direct insertion of indium in the presence of LiCl》 about this compound( cas:2689-65-8 ) in Angewandte Chemie, International Edition. Keywords: functionalized aryl heteroaryl indium halide preparation cross coupling iodoarene. Let’s learn more about this compound (cas:2689-65-8).

Sensitive functional groups, including ketone, aldehyde, and ester groups, may be present in aryl In reagents prepared in good to excellent yields by the treatment of aryl and heteroaryl iodides with In powder in the presence of LiCl. These functionalized organoindium(III) reagents readily undergo Pd-catalyzed cross-coupling with functionalized aryl iodides, including those containing NH or OH groups.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem