Category: naphthyridine

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Marchalin, Stefan; Mamani, Lucy Nieves Hinojosa; Ilavsky, Dusan; Pronayova, Nada; Lesko, Jan researched the compound: 5-Iodo-2-furaldehyde( cas:2689-65-8 ).Formula: C5H3IO2.They published the article 《Synthesis and spectral properties of 2-(5-R-2-furylmethylene)-3-oxobutanenitriles》 about this compound( cas:2689-65-8 ) in Collection of Czechoslovak Chemical Communications. Keywords: furylmethyleneoxobutanenitrile; butanenitrile furylmethylene; condensation furaldehyde aminobutenenitrile; substituent effect conjugation furylethylene system; LFER furylmethyleneoxobutanenitrile; structure property furylmethyleneoxobutanenitrile. We’ll tell you more about this compound (cas:2689-65-8).

Substituted 2-(5-R-2-furylmethylene)-3-oxobutanenitriles I (R = H, halo, Ph, etc.) were obtained by condensation of the corresponding 5-R-2-furaldehydes II with 3-amino-2-butenenitrile in acid medium. Relation between the structure and spectral properties (NMR, IR, UV, MS) is presented and the influence of substituents in position 5 of the furan ring on the conjugated 2-furylethylene system is discussed.

In addition to the literature in the link below, there is a lot of literature about this compound(5-Iodo-2-furaldehyde)Formula: C5H3IO2, illustrating the importance and wide applicability of this compound(2689-65-8).

Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Recommanded Product: 847818-64-8. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (1-Isobutyl-1H-pyrazol-5-yl)boronic acid, is researched, Molecular C7H13BN2O2, CAS is 847818-64-8, about Synthesis of pinacol esters of 1-alkyl-1H-pyrazol-5-yl- and 1-alkyl-1H-pyrazol-4-ylboronic acids. Author is Ivachtchenko, Alexandre V.; Kravchenko, Dmitry V.; Zheludeva, Valentina I.; Pershin, Dmitry G..

1-Substituted pyrazolylboronic acids and their pinacol esters were prepared by lithiation-borylation reaction sequence starting from bromopyrazoles. Alkylation of 4-bromo-1H-pyrazole gave 1-alkyl-4-bromo-1H-pyrazoles, which were lithiated at -80° and borylated with B(OMe)3 to give 1-R-1H-pyrazole-4-boronic acids [4a-g, R = Me, Et, Pr, (CH2)2CHMe2, (CH2)2OMe, (CH2)3NMe2, (CH2)2CH(OEt)2]. Lithiation of 4-bromo-1-(2-dimethylaminoethyl)-1H-pyrazole (2h) gave 5-lithio-derivative, which on borylation afforded 1-R1-4-Br-1H-pyrazole-5-boronic acid (8). Boronic acids 4a-g are unstable and were deborylated slowly due to hydrolysis by traces of water; the stability of boryl derivatives can be greatly enhanced by converting to corresponding pinacol boronates (10a-g). Direct lithiation of 1-R2-1H-pyrazoles by BuLi at -20° afforded 5-lithio-derivatives, which were converted to corresponding 1-R2-1H-pyrazole-5-boronic acids [17a-e; R2 = Me, iBu, Pr, (CH2)2CHMe2, (CH2)2CH(OEt)2] and their pinacol boronates (18a-e, same R2). The key step in the described methodol. is the regioselective lithiation of the pyrazole ring. The synthesized pinacolates are stable under prolonged storage and can be used as convenient reagents in organic synthesis.

In addition to the literature in the link below, there is a lot of literature about this compound((1-Isobutyl-1H-pyrazol-5-yl)boronic acid)Recommanded Product: 847818-64-8, illustrating the importance and wide applicability of this compound(847818-64-8).

Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Iodo-2-furaldehyde(SMILESS: IC1=CC=C(O1)C=O,cas:2689-65-8) is researched.Recommanded Product: 847818-64-8. The article 《Furan derivatives. LXXXII. Kinetics of the condensation of 5-nitro-2-furfuryl dichloromethyl sulfone with aldehydes》 in relation to this compound, is published in Collection of Czechoslovak Chemical Communications. Let’s take a look at the latest research on this compound (cas:2689-65-8).

The kinetics of condensation of I with II (R = H, Me, Cl, Br, iodo, CO2Me, NO2) and III (R1 = H, 4-Me, 4-Cl, 3,4-Cl2, 4-Br, 4-CO2Et, 2-NO2, 3-NO2, 4-NO2), resp., were correlated with substituent constants

In addition to the literature in the link below, there is a lot of literature about this compound(5-Iodo-2-furaldehyde)COA of Formula: C5H3IO2, illustrating the importance and wide applicability of this compound(2689-65-8).

Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Yakugaku Zasshi called Catalytic dehalogenation reaction, Author is Miyaki, Takaaki; Kataoka, Eisei, which mentions a compound: 1569-17-1, SMILESS is CC1=C2C=CC=NC2=NC=C1, Molecular C9H8N2, Formula: C9H8N2.

Catalytic dehalogenation of 2,7-dichloro-4-methyl-1,8-naphthyridine with Pd-CaCO3 gave 4-methylnaphthyridine and chloro-4-methylnaphthyridine (the details to be reported later). Catalytic dehalogenation of 2,4-dichloro-6-methylpyrimidine gave a compound whose picrate (m. 130-1°) did not depress the m. p. of 6-methylpyrimidine picrate. In like manner the following compounds were studied with the reaction indicated: 4-phenyl-2,6-dichloropyrimidine → C10H8N2, m. 66-7°; 1-bromo-β-naphthol → β-naphthol; 1-bromo-β-naphthol Me ether → β-naphthol Me ether; bromopiperonal → piperonal; o-BrC6H4NO2 → aniline + o-bromoaniline + 2,2′-dibromoazoxybenzene.

In addition to the literature in the link below, there is a lot of literature about this compound(4-Methyl-1,8-naphthyridine)Formula: C9H8N2, illustrating the importance and wide applicability of this compound(1569-17-1).

Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Action of Methyl Iodide and of Benzyl Chloride upon 2-Oxy-4-methyl-6-methylmercaptopyrimidine》. Authors are Wheeler, Henry L.; Mcfarland, David F..The article about the compound:4-Methyl-6-(methylthio)pyrimidin-2-olcas:16710-11-5,SMILESS:CSC1=NC(O)=NC(C)=C1).Name: 4-Methyl-6-(methylthio)pyrimidin-2-ol. Through the article, more information about this compound (cas:16710-11-5) is conveyed.

2-Methylmercapto-4-methyl-6-chloropyrimidine, C6H7N2ClS, was made from the oxypyrimidine and PCl5, b32-5 147°, m. 39-40°. This with KSH gave 2-methylmercapto-4-methyl-6-thiopyrimidine, C6H8N2S2, m. 214°, heating at 215-23° gave 2,6-dithio-4-methyluracil. Boiling the mercapto compound with HCl formed 6-thio-4-methyluracil, C6H6ON2S, prisms decompose above 250°, which with NaOH and MeI gives 2-oxy-4-methyl-6-methylmercaptopyrimidine, C6H8ON2S, needles, m. 174-5°. The mercaptopyrimidine with NaOH and PhCH2Cl yielded after treatment with HCl a mixture of 1-benzyl and 3-benzyluracil. The methylation of 2-oxy-4-methyl-6-methylmercaptopyrimidine gave 2-oxy-3,4-dimethyl-6-methylmercaptopyrimidine, C7H10ON2S, m. 170-1° and probably the 1,4-dimethyl product not isolated. 2-Oxy-4-methyl-6-o-nitrobenzylmercaptopyrimidine, m. 205°. 2-Oxy-4-methyl-6-m-dinitrophenylmercaptopyrimidine, m. 208°.

In addition to the literature in the link below, there is a lot of literature about this compound(4-Methyl-6-(methylthio)pyrimidin-2-ol)Name: 4-Methyl-6-(methylthio)pyrimidin-2-ol, illustrating the importance and wide applicability of this compound(16710-11-5).

Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Hrdina, M.; Jurasek, A.; Knoppova, V. published an article about the compound: 5-Iodo-2-furaldehyde( cas:2689-65-8,SMILESS:IC1=CC=C(O1)C=O ).Recommanded Product: 5-Iodo-2-furaldehyde. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:2689-65-8) through the article.

The kinetics of condensation of I with II (R = H, Me, Cl, Br, iodo, CO2Me, NO2) and III (R1 = H, 4-Me, 4-Cl, 3,4-Cl2, 4-Br, 4-CO2Et, 2-NO2, 3-NO2, 4-NO2), resp., were correlated with substituent constants

This literature about this compound(2689-65-8)Recommanded Product: 5-Iodo-2-furaldehydehas given us a lot of inspiration, and I hope that the research on this compound(5-Iodo-2-furaldehyde) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-Methyl-1,8-naphthyridine(SMILESS: CC1=C2C=CC=NC2=NC=C1,cas:1569-17-1) is researched.Recommanded Product: 5-Iodo-2-furaldehyde. The article 《The ultraviolet absorption spectra of monosubstituted 1,8-naphthyridines [1]》 in relation to this compound, is published in Zeszyty Naukowe Uniwersytetu Jagiellonskiego, Prace Chemiczne. Let’s take a look at the latest research on this compound (cas:1569-17-1).

UV absorption spectra of 1,8-naphthyridines were measured in MeOH. The effects of the substituent and its location in the naphthyridine ring on the spectral bands were analyzed. The spectral anal. revealed that 4-hydroxy-, 2-, and 4- mercapto-1,8-naphthyriolines had in MeOH the structures of 1,8-naphthyriolin-4-(1H)-one, 1,8-naphthyridin-2(1H)-thione, and -4(1H)-thione resp.

This literature about this compound(1569-17-1)Quality Control of 4-Methyl-1,8-naphthyridinehas given us a lot of inspiration, and I hope that the research on this compound(4-Methyl-1,8-naphthyridine) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Recommanded Product: 2689-65-8. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-Iodo-2-furaldehyde, is researched, Molecular C5H3IO2, CAS is 2689-65-8, about Palladium-Catalyzed Arylation of Cyclopropanes via Directing Group-Mediated C(sp3)-H Bond Activation To Construct Quaternary Carbon Centers: Synthesis of cis- and trans-1,1,2-Trisubstituted Chiral Cyclopropanes.

Pd(II)-catalyzed tertiary C(sp3)-H arylation of cyclopropanes via directing group-mediated C-H activation for the construction of a chiral quaternary carbon center on cyclopropanes using aryl iodides as a coupling partner is reported. The arylation had a wide substrate scope and good functional group tolerance, including heteroaryl iodides, to provide various chiral arylcyclopropanes with the cis- and trans-1,1,2-trisubstituted structures.

This literature about this compound(2689-65-8)Recommanded Product: 2689-65-8has given us a lot of inspiration, and I hope that the research on this compound(5-Iodo-2-furaldehyde) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 4-Methyl-1,8-naphthyridine, is researched, Molecular C9H8N2, CAS is 1569-17-1, about Identification of 1,5-Naphthyridine Derivatives as a Novel Series of Potent and Selective TGF-β Type I Receptor Inhibitors.Recommanded Product: 1569-17-1.

Optimization of the screening hit I led to the identification of novel 1,5-naphthyridine aminothiazole and pyrazole derivatives, which are potent and selective inhibitors of the transforming growth factor-β type I receptor, ALK5. Compounds II and III, which inhibited ALK5 autophosphorylation with IC50 = 6 and 4 nM, resp., showed potent activities in both binding and cellular assays and exhibited selectivity over p38 mitogen-activated protein kinase. The X-ray crystal structure of III in complex with human ALK5 is described, confirming the binding mode proposed from docking studies.

This literature about this compound(1569-17-1)Recommanded Product: 1569-17-1has given us a lot of inspiration, and I hope that the research on this compound(4-Methyl-1,8-naphthyridine) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Dipole moments of some furfural derivatives》. Authors are Kova-lenko, K. N.; Minkin, V. I.; Nazarova, Z. N.; Kazachenko, D. V..The article about the compound:5-Iodo-2-furaldehydecas:2689-65-8,SMILESS:IC1=CC=C(O1)C=O).Formula: C5H3IO2. Through the article, more information about this compound (cas:2689-65-8) is conveyed.

The following values of dipole moments (in D.) were determined from the dielec. data in C6H6 at 25°: furfural 3.56; 5-bromofurfural 3.37; 5-iodofurfural 3.29; 5-chiorofurfural 3.37; 5-nitrofurfural 3.46; 5-nitrofurfurylidene diacetate 4.26; the following values were found in dioxane: furfural 3.6, 5-iodofurrural 3.39. The results indicate that free rotation of the CHO group in furfural and its 5-halo derivatives is restricted and the mols. exist mainly in a conformation with the CHO-oxygen atom disposed toward the ring O atom.

This literature about this compound(2689-65-8)Formula: C5H3IO2has given us a lot of inspiration, and I hope that the research on this compound(5-Iodo-2-furaldehyde) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem