Category: naphthyridine

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 91523-50-1, is researched, Molecular C10H11NO3, about Bioactive constituents of Zanthoxylum rhetsa bark and its cytotoxic potential against B16-F10 melanoma cancer and normal human dermal fibroblast (HDF) cell lines, the main research direction is Zanthoxylum bark cytotoxic potential melanoma cancer HDF bioactive cell; GC-MS; NMR spectroscopy; Zanthoxylum rhetsa; alkaloids; cytotoxicity; lignans; triterpenes.Electric Literature of C10H11NO3.

Zanthoxylum rhetsa is an aromatic tree, known vernacularly as “”Indian Prickly Ash””. It has been predominantly used by Indian tribes for the treatment of many infirmities like diabetes, inflammation, rheumatism, toothache and diarrhea. In this study, we identified major volatile constituents present in different solvent fractions of Z. rhetsa bark using GC-MS anal. and isolated two THF lignans (yangambin and kobusin), a berberine alkaloid (columbamine) and a triterpenoid (lupeol) from the bioactive chloroform fraction. The solvent fractions and purified compounds were tested for their cytotoxic potential against human dermal fibroblasts (HDF) and mouse melanoma (B16-F10) cells, using the MTT assay. All the solvent fractions and purified compounds were found to be non-cytotoxic to HDF cells. However, the chloroform fraction and kobusin exhibited cytotoxic effect against B16-F10 melanoma cells. The presence of bioactive lignans and alkaloids were suggested to be responsible for the cytotoxic property of Z. rhetsa bark against B16-F10 cells.

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1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Iodo-2-furaldehyde(SMILESS: IC1=CC=C(O1)C=O,cas:2689-65-8) is researched.Electric Literature of C10H11NO3. The article 《Knoevenagel condensation of some 5-substituted furan-2-carboxaldehyde with creatinine and their antimicrobial screening》 in relation to this compound, is published in International Journal of ChemTech Research. Let’s take a look at the latest research on this compound (cas:2689-65-8).

A series of heterocyclic compounds of 5-(5-R-furfurylidene)-creatinine were prepared and screened for their antimicrobial activity, these compounds were identified by their m.ps., IR, Ultraviolate and NMR spectra.

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1,8-Naphthyridine – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-Iodo-2-furaldehyde, is researched, Molecular C5H3IO2, CAS is 2689-65-8, about Formation of α-chiral centers by asymmetric β-C(sp3)-H arylation, alkenylation, and alkynylation.Recommanded Product: 5-Iodo-2-furaldehyde.

The enzymic β-C-H hydroxylation of the feedstock chem. isobutyric acid has enabled the asym. synthesis of a wide variety of polyketides. The analogous transition metal-catalyzed enantioselective β-C-H functionalization of isobutyric acid-derived substrates should provide a versatile method for constructing useful building blocks with enantioenriched α-chiral centers from this abundant C-4 skeleton. However, the desymmetrization of ubiquitous iso-Pr moieties by organometallic catalysts has remained an unanswered challenge. Herein, the authors report the design of chiral mono-protected aminomethyl oxazoline ligands that enable desymmetrization of iso-Pr groups via palladium insertion into the C(sp3)-H bonds of one of the prochiral Me groups. We detail the enantioselective β-arylation, -alkenylation, and -alkynylation of isobutyric acid/2-aminoisobutyric acid derivatives, which may serve as a platform for the construction of α-chiral centers.

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1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Angewandte Chemie, International Edition called Direct Synthesis of Water-Tolerant Alkyl Indium Reagents and Their Application in Palladium-Catalyzed Couplings with Aryl Halides, Author is Shen, Zhi-Liang; Goh, Kelvin Kau Kiat; Yang, Yong-Sheng; Lai, Yin-Chang; Wong, Colin Hong An; Cheong, Hao-Lun; Loh, Teck-Peng, which mentions a compound: 2689-65-8, SMILESS is IC1=CC=C(O1)C=O, Molecular C5H3IO2, COA of Formula: C5H3IO2.

A mild, efficient and straightforward method for the synthesis of water-tolerant alkyl indium reagent through CuCl-mediated direct insertion of indium into alkyl halide in THF at room temperature is described.

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1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1569-17-1, is researched, SMILESS is CC1=C2C=CC=NC2=NC=C1, Molecular C9H8N2Journal, Zeszyty Naukowe Uniwersytetu Jagiellonskiego, Prace Chemiczne called The ultraviolet absorption spectra of monosubstituted 1,8-naphthyridines [1], Author is Wozniak, Marian; Tomula, Maria, the main research direction is optical absorption naphthyridine substituent effect; UV naphthyridine substituent effect.Recommanded Product: 1569-17-1.

UV absorption spectra of 1,8-naphthyridines were measured in MeOH. The effects of the substituent and its location in the naphthyridine ring on the spectral bands were analyzed. The spectral anal. revealed that 4-hydroxy-, 2-, and 4- mercapto-1,8-naphthyriolines had in MeOH the structures of 1,8-naphthyriolin-4-(1H)-one, 1,8-naphthyridin-2(1H)-thione, and -4(1H)-thione resp.

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1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Thiocyanopyrrole, thiopyrroles and pyrrole disulfides》. Authors are Pratesi, P..The article about the compound:5-Iodo-2-furaldehydecas:2689-65-8,SMILESS:IC1=CC=C(O1)C=O).Product Details of 2689-65-8. Through the article, more information about this compound (cas:2689-65-8) is conveyed.

Thiocyanopyrroles have been prepared by addition of Br2 to pyrrole and NH4SCN in glacial AcOH, theoretical quantities being used according to the scheme RH + 2NH4SCN + Br2 → RSCN + 2NH4Br + HSCN. With ordinary pyrrole, the reaction mix is cooled with ice and salt. The yields are 90-5%. 2,4-Dimethyl-3-carbethoxy-5-thiocyanopyrrole (I), m. 169.5°. The 5-carbethoxy-3-thiocyano derivative (II), m. 198-9°. A dithiocyanopyrrole, C4H3N(SCN)2, m. 114°, was the only product obtained in an attempt to produce the tetrathiocyanate. Thiocyanopyrroles are very stable compounds, indifferent toward alkalies. They crystallize very readily, usually in needle form, and are readily purified and recrystallized from H2O or EtOH. With Zn and AcOH the corresponding thiopyrrole is formed. Thus, 2,4-dimethyl-5-carbethoxy-3-thiopyrrole (III), m. 140°, is formed by the reduction of II; yield, 50%. These compounds resemble the thiophenols, being soluble in alkali and insoluble in alk. bicarbonates. They react readily with Hg salts, giving compounds of the types: RSHgX, and (RS)2Hg [X = halogen]. The thiopyrroles oxidize readily in air, forming the disulfides. Oxidation of III by boiling in the presence of bone black gave bis[2,4-dimethyl-5-carbethoxy-3-pyrryl disulfide. On cooling the disulfide seps. quantitatively, as a white powder, m. 234°, insoluble in alkali, slightly soluble in EtOH. IV was also obtained directly from the NCS derivative by reduction with Na and EtOH.

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1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.D’Auria, Maurizio researched the compound: 5-Iodo-2-furaldehyde( cas:2689-65-8 ).Category: naphthyridine.They published the article 《Photochemical reactivity of halofuran and halothiophene derivatives with benzimidazole》 about this compound( cas:2689-65-8 ) in Heterocycles. Keywords: iodofuran benzimidazole photochem coupling; iodothiophene benzimidazole photochem coupling; benzimidazolylthiophene; benzimidazolylfuran; thiophene benzimidazolyl; furan benzimidazolyl. We’ll tell you more about this compound (cas:2689-65-8).

A photochem. approach to the synthesis of 5-(4-benzimidazolyl)-2-thiophenes, e.g., I (X = S, R = H, Me) and 5-(4-benzimidazolyl)-2-furan I (X = O, R = H) by the irradiation of benzimidazole with iodothiophenes II (X = S, R = H, Me) and iodofuran II (X = O, R = H) in MeCN is described.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 91523-50-1, is researched, Molecular C10H11NO3, about Bioactive constituents of Zanthoxylum rhetsa bark and its cytotoxic potential against B16-F10 melanoma cancer and normal human dermal fibroblast (HDF) cell lines, the main research direction is Zanthoxylum bark cytotoxic potential melanoma cancer HDF bioactive cell; GC-MS; NMR spectroscopy; Zanthoxylum rhetsa; alkaloids; cytotoxicity; lignans; triterpenes.COA of Formula: C10H11NO3.

Zanthoxylum rhetsa is an aromatic tree, known vernacularly as “”Indian Prickly Ash””. It has been predominantly used by Indian tribes for the treatment of many infirmities like diabetes, inflammation, rheumatism, toothache and diarrhea. In this study, we identified major volatile constituents present in different solvent fractions of Z. rhetsa bark using GC-MS anal. and isolated two THF lignans (yangambin and kobusin), a berberine alkaloid (columbamine) and a triterpenoid (lupeol) from the bioactive chloroform fraction. The solvent fractions and purified compounds were tested for their cytotoxic potential against human dermal fibroblasts (HDF) and mouse melanoma (B16-F10) cells, using the MTT assay. All the solvent fractions and purified compounds were found to be non-cytotoxic to HDF cells. However, the chloroform fraction and kobusin exhibited cytotoxic effect against B16-F10 melanoma cells. The presence of bioactive lignans and alkaloids were suggested to be responsible for the cytotoxic property of Z. rhetsa bark against B16-F10 cells.

I hope my short article helps more people learn about this compound(6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid)COA of Formula: C10H11NO3. Apart from the compound(91523-50-1), you can read my other articles to know other related compounds.

Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 16710-11-5, is researched, SMILESS is CSC1=NC(O)=NC(C)=C1, Molecular C6H8N2OSJournal, Article, Journal of Organic Chemistry called Pyrimidine nucleosides. I. Synthesis of 6-methylcytidine, 6-methyluridine, and related 6-methylpyrimidine nucleosides, Author is Winkley, Michael W.; Robins, Roland K., the main research direction is pyrimidine nucleosides; nucleosides pyrimidine; cytosines; cytidines; uridines; uracils; ribofuranosyls; methylpyrimidine nucleosides.Safety of 4-Methyl-6-(methylthio)pyrimidin-2-ol.

Synthesis of 6-methylprimidine nucleosides was realized. 6-Methylcytidine (I) and 6-methyl-2′-deoxycytidine were prepared by direct utilization of 6-methylcytosine (II) via silylation and subsequent treatment with the appropriate per-O-acetylglycosyl halide in MeCN. Conversion of I into 6-methyluridine was achieved in 65% yield. This direct glycosylation procedure applied to 6-methyluracil gave 6-methyl-3-(β-D-ribofuranosyl)uracil as the major product. Utilization of this general method resulted in preparation of 5,6-dimethyluridine. A new route to the synthesis of II is reported. 31 references.

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1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Infrared spectroscopic study of the condensation reaction of halofurfural with ketones》. Authors are Usmanov, Z.; Tadzhieva, M. A..The article about the compound:5-Iodo-2-furaldehydecas:2689-65-8,SMILESS:IC1=CC=C(O1)C=O).Application of 2689-65-8. Through the article, more information about this compound (cas:2689-65-8) is conveyed.

The reactions of furfuryl iodide (I) and bromide (II) with ketones were investigated. NaOH (3-5 ml., 5%), 0.05 mole halofurfural, and 0.8-3 ml. ketone were added to 20 ml. solvent. The reaction lasted 1-2 hrs. The product was precipitated with 30-50 ml. H2O and dried. The light-yellow oily products were investigated in C2H4Cl2 solutions, the crystalline products in pressed KBr disks. The compositions of the condensation products of I with methyl nonyl ketone, methyl naphthyl ketone, and acetophenone were C16H23O2I, C17H11O2I, and C13H9O2I, resp. The condensations of II with methyl alkyl ketones, where the alkyl group was Et, Pr, Bu, amyl, hexyl, isopropyl, and isobutyl, and with acetophenone and acetylacetone, led to C9H9O2Br, C10H11O2Br, C11H13O2Br, C12H15O2Br, C13H17O2Br, C10H11O2Br, C11H13O2Br, C13H9O2Br, and C10H9O3Br, resp. The ir spectra indicate the functional groups present in the various products.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem