Category: naphthyridine

Weissenfels, Manfred published the artcilePhotocatalytic systems. VIII. Preparation of 1,8-naphthyridine aldehydes, Formula: C10H10N2, the publication is Zeitschrift fuer Chemie (1978), 18(1), 20-1, database is CAplus.

Oxidation of methylnaphthyridines I (R = Me, R¹ = H, Me) with SeO₂ gave the corresponding aldehydes I (R = CHO, R¹ = H, CHO), characterized as the oximes, semicarbazones, etc. Benzoin reaction of I (R = CHO, R¹ = H) gave II, which was oxidized by air to III.

Zeitschrift fuer Chemie published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C5H10N2OS, Formula: C10H10N2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Vintu, M. published the artcileIndolo[3,2-b]carbazole-based poly(arylene ethynylene)s through Sonogashira coupling for optoelectronic and sensing applications, Formula: C18H10, the publication is Journal of Applied Polymer Science (2019), 136(2), n/a, database is CAplus.

Two indolo[3,2-b]carbazole (ICZ)-based polymers were designed and synthesized using Sonogashira cross-coupling based on dibromoindolo[3,2-b]carbazoles and 2,7-diethynylfluorene or 9,10-diethynylanthracene. The 2, 8 positions of the ICZ moiety was used for the bridging of arylene ethynylene structure to form the polymer backbone. The characterization was done by FTIR, ¹H NMR, UV-visible and (UV-visible) fluorescence spectroscopic methods. The polymers, moderately soluble in aprotic and chlorinated solvents, possess thermal stability >300°. The band gap examinations, executed through cyclic voltammetry and complemented by UV-visible studies, indicated their semiconducting nature and the possibility for their use for the fabrication of polymer solar cells and for optical switching applications. The new diethynylindolocarbazole systems act as Broensted acid sensors as well as a Hg²⁺ receptors. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46940.

Journal of Applied Polymer Science published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C8H13BN2O4, Formula: C18H10.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Duncan, Kristal published the artcileNSAIDs induce apoptosis in nonproliferating ovarian cancer cells and inhibit tumor growth in vivo, COA of Formula: C20H17FO4S, the publication is IUBMB Life (2012), 64(7), 636-643, database is CAplus and MEDLINE.

Ovarian cancer (OC) is one of the most lethal gynaecol. cancers, which usually has a poor prognosis due to late diagnosis. A large percentage of the OC cell population is in a nonproliferating and quiescent stage, which poses a barrier to success when using most chemotherapeutic agents. Recent studies have shown that several nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in the treatment of OC. Furthermore, we have previously described the mol. mechanisms of NSAIDs’ induction of cancer apoptosis. In this report, we evaluated various structurally distinct NSAIDs for their efficacies in inducing apoptosis in nonproliferating OC cells. Although several NSAIDs-induced apoptosis, Flufenamic Acid, Flurbiprofen, Finasteride, Celocoxib, and Ibuprofen were the most potent NSAIDs inducing apoptosis. A combination of these agents resulted in an enhanced effect. Furthermore, we demonstrate that the combination of Flurbiprofen, which targets nonproliferative cells, and Sulindac Sulfide, that affects proliferative cells, strongly reduced tumor growth when compared with a single agent treatment. Our data strongly support the hypothesis that drug treatment regimens that target nonproliferating and proliferating cells may have significant efficacy against OC. These results also provide a rationale for employing compounds or even chem. modified NSAIDs, which selectively and efficiently induce apoptosis in cells during different stages of the cell cycle, to design more potent anticancer drugs. © 2012 IUBMB IUBMB Life, 2012.

IUBMB Life published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, COA of Formula: C20H17FO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Behlen, Michael J. published the artcileC₂-Symmetric dinickel catalysts for enantioselective [4 + 1]-cycloadditions, Safety of 2,7-Dimethyl-1,8-naphthyridine, the publication is Journal of the American Chemical Society (2020), 142(41), 17294-17300, database is CAplus and MEDLINE.

Dinickel naphthyridine-bis(oxazoline) catalysts promote enantioselective intermol. [4 + 1]-cycloadditions of vinylidene equivalent and 1,3-dienes. The products of this reaction are methylenecyclopentenes, and the exocyclic alkene is generally obtained with high Z selectivity. E- and Z-dienes react in a stereoconvergent fashion, providing cycloadducts with the same sense of absolute stereochem. and nearly identical ee values. This feature allows dienes that are com. available as E/Z mixtures to be used as substrates for the cycloaddition A DFT model for the origin of asym. induction is provided.

Journal of the American Chemical Society published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Safety of 2,7-Dimethyl-1,8-naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Dahal, Gopal P. published the artcileA Fragment Library Screening Approach to Identify Selective Inhibitors against an Essential Fungal Enzyme, Product Details of C10H9NO4S, the publication is SLAS Discovery (2018), 23(6), 520-531, database is CAplus and MEDLINE.

Pathogenic fungi represent a growing threat to human health, with an increase in the frequency of drug-resistant fungal infections. Identifying targets from among the selected metabolic pathways that are unique to microbial species presents an opportunity to develop new antifungal agents against new and untested targets to combat this growth threat. Aspartate semialdehyde dehydrogenase (ASADH) catalyzes a key step in a uniquely microbial amino acid biosynthetic pathway and is essential for microbial viability. This enzyme, purified from four pathogenic fungal organisms (Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans, and Blastomyces dermatitidis), has been screened against fragment libraries to identify initial enzyme inhibitors. The binding of structural analogs of the most promising lead compounds was measured against these fungal ASADHs to establish important structure-activity relationships among these different inhibitor classes. The most potent of these inhibitors have been docked into structures of this fungal enzyme target to identify important structural elements that serve as critical binding determinants. Several inhibitors with low micromolar inhibition constants have been identified that showed selectivity against these related enzymes from different fungal species. Subsequent screening against a library of drugs and drug candidates identified some addnl. inhibitors containing a consistent set of functional groups required for fungal ASADH inhibition. Addnl. elaboration of these core structures will likely lead to more potent and selective inhibitors.

SLAS Discovery published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Product Details of C10H9NO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Pinxterhuis, Erik B. published the artcileFast, Efficient and Low E-Factor One-Pot Palladium-Catalyzed Cross-Coupling of (Hetero)Arenes, SDS of cas: 2960-93-2, the publication is Angewandte Chemie, International Edition (2018), 57(30), 9452-9455, database is CAplus and MEDLINE.

The homocoupling of aryl halides and the heterocoupling of aryl halides with either aryl bromides or arenes bearing an ortho-lithiation directing group are presented. The use of a Pd catalyst, in combination with t-BuLi, allows for the rapid and efficient formation of a wide range of polyaromatic compounds in a one pot procedure bypassing the need for the sep. preformation of an organometallic coupling partner. These polyaromatic structures were obtained in high yields, in 10 min at room temperature, with minimal waste generation (E-factors as low as 1.5) and without the need for strict inert conditions, making this process highly efficient and practical in comparison to classical methods. As illustration, several key intermediates of widely used BINOL-derived structures are readily prepared including the highly desired precursor to the chiral TRIP phosphoric acid.

Angewandte Chemie, International Edition published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, SDS of cas: 2960-93-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Jones, Richard A. Y. published the artcileKinetics of quaternization of some naphthyridines and methylnaphthyridines, Related Products of naphthyridine, the publication is Chemical Communications (London) (1969), 56-7, database is CAplus.

The 2nd order rate constants for the reaction of MeI with some naphthyridines and methylnaphthridines in MeCN were determined by a conductimetric method. The following results were obtained at 24.8° (compound, and rate constant × 10-4 l./mole/sec. given): quinoline, 0.517; isoquinoline, 4.23; 1,5-naphthyridine, 0.232; 1,6-naphthyridine, 1.66; 1,8-naphthyridine, 4.25; 2-methyl-1,8-naphthyridine, 3.61; 3-methyl-1,8-naphthyridine, 5.74; 4-methyl-1,8-naphthyridine, 7.26; and 2,7-dimethyl-1,8-naphthyridine, 1.85. The rate constants are used to deduce the quaternization kinetics of the reactions.

Chemical Communications (London) published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Related Products of naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Hellinghausen, Garrett published the artcileImproving peak capacities over 100 in less than 60 seconds: operating above normal peak capacity limits with signal processing, Application In Synthesis of 2960-93-2, the publication is Analytical and Bioanalytical Chemistry (2020), 412(8), 1925-1932, database is CAplus and MEDLINE.

A primary focus in liquid chromatog. anal. of complex samples is high peak capacity separations Using advanced instrumentation and optimal small, high-efficiency columns, complex multicomponent mixtures can now be analyzed in relatively short times. Despite these advances, chromatog. peak overlap is still observed Recently, attention has shifted from improvements in chromatog. efficiency and selectivity to enhancing data processing after collection. Curve fitting methods can be used to trace underlying peaks, but do not directly enhance chromatog. resolution Methods based on the properties of derivatives and power transform were recently shown to enhance chromatog. peak resolution while maintaining critical peak information (peak areas and retention times). These protocols have been extensively investigated for their fundamental properties, advantages, and limitations, but they have not been evaluated with complex chromatograms. Herein, we evaluate the use of deconvolution via Fourier transform (FT), even-derivative peak sharpening, and power law with the fast separation (< 60 s) of a 101-component mixture using ultra-high-pressure liquid chromatog. High noise and peak overlap are present in this gradient separation, which is representative of fast chromatog. Chromatog. resolution enhancement is demonstrated and described. Further, accurate quantitation is maintained and shown with representative examples. Enhancements in peak capacity and peak-to-peak resolutions are discussed. Finally, the statistical theory of overlap is used for 101 peaks and predictions are made for the number of singlet, doublet, and multiplets analyte peaks. The effect of increasing peak capacity by FT even derivative sharpening and power laws leads to a decrease in the number of peak overlaps and an increase in total peak number

Analytical and Bioanalytical Chemistry published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, Application In Synthesis of 2960-93-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Goudappagouda published the artcileCascade energy transfer and tunable emission from nanosheet hybrids: locating acceptor molecules through chiral doping, Application of 9,10-Diethynylanthracene, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(52), 7072-7075, database is CAplus and MEDLINE.

Light harvesting donor-acceptor assemblies are indispensable to efficiently tap photons. In an attempt to improve the light harvesting efficiency of an acceptor doped assembly, the authors design and synthesize a donor-acceptor-donor triad which exhibits an exceptional intramol. energy transfer with excellent efficiency. Also, a facile cascade energy transfer (energy funneling) is observed in the presence of 2nd acceptors (63-91% efficiency) with tunable emission colors. Self-assembled nanosheets formed by the triad in the presence of acceptors exhibit cascade energy transfer assisted tunable emission. Use of chiral acceptors induces chirality to the triad and gave chiral nanosheets along with cascade energy transfer. Here chiral induction, nanosheet formation and cascade energy transfer in the presence of chiral acceptors are used as tools to probe the intercalation of acceptor mols. in the donor scaffold.

Chemical Communications (Cambridge, United Kingdom) published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Application of 9,10-Diethynylanthracene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Vu, Choua published the artcileElaboration of 1,8-naphthyridine-2,7-dicarboxaldehyde into novel 2,7-dimethylimine derivatives, Name: 2,7-Dimethyl-1,8-naphthyridine, the publication is Journal of Heterocyclic Chemistry (2002), 39(4), 829-832, database is CAplus.

The condensation of 1,8-naphthyridine-2,7-dicarboxaldehyde, available by SeO₂ oxidation of 2,7-dimethyl-1,8-naphthyridine, with various primary amines RNH₂ (R = Me₃C, PhCH₂, EtSCH₂CH₂, cyclohexyl, 1-adamantyl) in MeOH afforded diimines I in reasonable to excellent yields (56-84%) after recrystallization Naphthyridines I typically displayed the NMR spectra consistent with a mirror plane perpendicular to the naphthyridine plane and syn,syn relationships of the naphthyridine moiety with each imine nitrogen lone pair.

Journal of Heterocyclic Chemistry published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C11H10O, Name: 2,7-Dimethyl-1,8-naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem