Category: naphthyridine

In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system. 16415-12-6, Name is Hexadecyltrimethoxysilane, SMILES is CO[Si](OC)(CCCCCCCCCCCCCCCC)OC, belongs to naphthyridine compound. In a document, author is Di Braccio, Mario, introduce the new discover, Formula: https://www.ambeed.com/products/16415-12-6.html.

On the basis of the good anti-inflammatory properties shown by the 9-alkyl-N,N-dialkyl-5-(alkylamino)[1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamides 1, a series of analogues of such compounds, in which the 9-alkyl substituent was replaced by an ester or amide group (compounds 3a-i), was prepared and tested (inhibition of carrageenan-induced paw edema in the rat). Also two 5-(N-alkylN-acylamino) derivatives (compounds 4a,b) were synthesized and evaluated for the same purpose. Even though the general trend for these new [1,2,4]triazolo[4,3-a][1,8]naphthyridine derivatives was a decrease in activity compared with compounds 1, some of the new synthesized compounds exhibited still good anti-inflammatory properties. (c) 2007 Elsevier Masson SAS. All rights reserved.

Future efforts will undeniably focus on the diversification of the new catalytic transformations. In my other articles, you can also check out more blogs about 16415-12-6. Formula: https://www.ambeed.com/products/16415-12-6.html.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

You could be based in a university, combining chemical research with teaching; in a pharmaceutical company, working on developing and trialing new drugs; helping to ensure national healthcare provision keeps pace with new discoveries. , Synthetic Route of 88847-89-6, 88847-89-6, Name is 2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione, molecular formula is C10H13N5O5, belongs to naphthyridine compound. In a document, author is Wall, Richard J., introduce the new discover.

The lack of information regarding the mechanisms of action (MoA) or specific molecular targets of phenotypically active compounds can prove a barrier to their development as chemotherapeutic agents. Here, we report the results of our orthogonal genetic, molecular, and biochemical studies to determine the MoA of a novel 7-substituted 8-hydroxy-1,6-naphthyridine (8-HNT) series that displays promising activity against Trypanosoma brucei and Leishmania donovani. High-throughput loss-of-function genetic screens in T. brucei highlighted two probable zinc transporters associated with resistance to these compounds. These transporters localized to the parasite Golgi apparatus. Directed by these findings, the role of zinc and other divalent cations in the MoA of these compounds was investigated. 8-HNT compounds were found to directly deplete intracellular levels of Zn2+ while the addition of exogenous Zn2+ and Fe2+ reduced the potency of compounds from this series. Detailed biochemical analyses confirmed that 8-HNT compounds bind directly to a number of divalent cations, predominantly Zn2+ , Fe2+ and Cu2+ forming 2:1 complexes with one of these cations. Collectively, our studies demonstrate transition metal depletion, due to chelation, as the MoA of the 8-HNT series of compounds. Strategies to improve the selectivity of 8-HNT compounds are discussed.

Synthetic Route of 88847-89-6, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 88847-89-6 is helpful to your research.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is Han, Zheng-Guo, once mentioned the application of 39156-41-7, Name is 4-Methoxybenzene-1,3-diamine sulfate. Now introduce a scientific discovery about this category, HPLC of Formula: https://www.ambeed.com/products/39156-41-7.html.

A series of new heterocyclic compounds, involving pyrimido[4,5-b][1,6]-, benzo[b][1,6]-, pyrazolo[3,4-b][1,6]naphthyridine, and aza-benzo[b]fluorene skeletons were successfully synthesized via the reaction of structurally diverse 3,5-dibenzylidenepiperidin-4-one with various enamine-likes (2,6-diaminopyrimidin-4(3H)-one, 3-amino-5,5-dimethylcyclohex-2-enone, 3-methyl-1-phenyl-1H-pyrazol-5-amine and 1H-benzo-[d]imidazol-2-amine) in glycol under microwave irradiation. This method has the advantages of short synthetic route, operational simplicity, and increased safety for small-scale fast synthesis for biomedical screening.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. Welcome to check out more blogs about 39156-41-7, in my other articles. HPLC of Formula: https://www.ambeed.com/products/39156-41-7.html.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Chemical research careers are more diverse than they might first appear, as there are many different reasons to conduct research and many possible environments. , Computed Properties of https://www.ambeed.com/products/96-49-1.html, 96-49-1, Name is Ethylene carbonate, molecular formula is C3H4O3, belongs to naphthyridine compound. In a document, author is Anwer, Kurls E., introduce the new discover.

THE NEWLY synthesized compounds based on 2-amino-6-(2,4-dimethoxyphenyl)-4-(4-methoxyphenyl)nicotinonitrile 1. The reactivity of pyridine derivative 1 was studied towards different reagents by its reaction with malononitrile, 2-(4-chlorobenzylidene) malononitrile, ethyl cyanoacetate, cyano acetic acid, m-nitro benzaldehyde, sodium azide, formamide, acetic anhydride and/or acetic anhydride/H2SO4 to give compounds 2-5,7, 10-13, respectively. The reaction of 5 with acetyl acetone gave the bipyridine derivative 6, while reaction of compound 7 with chloroacetyl chloride and phenacyl bromide gave the azetidinone derivatives 8 and 9. The formimidate 14 were obtained via reaction of compound 1 with triethylorthoformate, while reaction of 14 with phenylene diamine and/or acetamide gave the formimidamide and pyridopyrimidine derivatives 15 and 16 respectively. Compound 1 was also allowed to react with urea, thiourea, phthalic anhydride, succinic anhydride, benzoyl chloride, chloroacetonitrile, chloroacetyl chloride, p-toluenesulfonylchloride and ethyl bromoacetate to give compounds 17a,b – 24. Reaction of compound 1 with dichloro reagents in 1:1 ratio gave the bicyclic derivatives 25a-c, while its reaction with oxalyl chloride, dichloro and tetrachlorobenzoquinone derivatives, and/or dichloronaphthoquinone gave the imidazopyridine derivatives 26-29. Reaction of compound 29 with o-phenylenediamine in 1:2 ratio afforded the di-condenesed product 30 while, reaction of compound 1 with dichlororeagents in 1:2 ratio gave the polyalkyl derivatives 31a-b. The newly synthesized compounds were characterized by IR, H-1-NMR, C-13-NMR and mass spectra. On the other hand the antimicrobial and anticancer activities of some of the newly synthesized compounds were studied and evaluated.

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.Welcome to check out more blogs about 96-49-1, in my other articles. Computed Properties of https://www.ambeed.com/products/96-49-1.html.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Chemical research careers are more diverse than they might first appear, as there are many different reasons to conduct research and many possible environments. , COA of Formula: https://www.ambeed.com/products/136-95-8.html, 136-95-8, Name is Benzo[d]thiazol-2-amine, molecular formula is C7H6N2S, belongs to naphthyridine compound. In a document, author is Judit Toth, introduce the new discover.

A convenient six-step route to the previously unknown 1H-pyrrolo[2,3-f]benzo[b][1,8]naphthyridine ring system using an intramolecular 1,3-dipolar cycloaddition of nonstabilized azomethine ylides has been described.

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.Welcome to check out more blogs about 136-95-8, in my other articles. COA of Formula: https://www.ambeed.com/products/136-95-8.html.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment. 92-70-6, Name is 3-Hydroxy-2-naphthoic acid, SMILES is C1=C2C(=CC(=C1C(O)=O)O)C=CC=C2, belongs to naphthyridine compound. In a document, author is Wang Wen-Zhen, introduce the new discover, Application of 92-70-6.

Based on the ligand (2,7-bis(alpha-pyrimidylamino)-1,8-naphthyridine (H(2)bpmany)), a linear pentachromium complex [Cr-5(mu(5)-bpmany)(4)Cl-2]PF6(1, mu(5)-bpmany = 2,7-bis(a-pyrimidylamino)-1,8-naphthyridine) was synthesized. The crystal structure of compound 1 has been characterized by X-ray crystallography. Interestingly, one metal atom in the center is missing in this linear chain, leading to the defective pentachromium metal string structure which is similar with the reported complex [Cr-5(mu(5)-dpznda)(4)Cl-2] (2, dpznda = N-2,N-7-di(pyrazin-2-yl)-1,8-naphthyridine-2,7-diamine). The central Cr(III) ion of 1 is eight-coordinated and is also rare in the chromium complex. The reaction of carbon dioxide with propylene oxide that generates propylene carbonate (PC) when catalyzed by [Cr-5(mu(5)-bpmany)(4)Cl-2]PF6 was investigated. Different reaction conditions including temperature and pressure were studied to optimize the reaction conditions.

Application of 92-70-6, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 92-70-6.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 5089-22-5, Name is 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene, molecular formula is C24H14N2O2, Electric Literature of 5089-22-5, belongs to naphthyridine compound, is a common compound. In a patnet, author is Javier Perez-Areales, Francisco, once mentioned the new application about 5089-22-5.

Aim: Simultaneous modulation of several key targets of the pathological network of Alzheimer’s disease (AD) is being increasingly pursued as a promising option to fill the critical gap of efficacious drugs against this condition. Materials & methods: A short series of compounds purported to hit multiple targets of relevance in AD has been designed, on the basis of their distinct basicities estimated from high-level quantum mechanical computations, synthesized, and subjected to assays of inhibition of cholinesterases, BACE-1, and A beta 42 and tau aggregation, of antioxidant activity, and of brain permeation. Results: Using, as a template, a lead rhein-huprine hybrid with an interesting multitarget profile, we have developed second-generation compounds, designed by the modification of the huprine aromatic ring. Replacement by [1,8]-naphthyridine or thieno[3,2-e] pyridine systems resulted in decreased, although still potent, acetylcholinesterase or BACE-1 inhibitory activities, which are more balanced relative to their A beta 42 and tau antiaggregating and antioxidant activities. Conclusion: Second-generation naphthyridine-and thienopyridine-based rhein-huprine hybrids emerge as interesting brain permeable compounds that hit several crucial pathogenic factors of AD.

Electric Literature of 5089-22-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 5089-22-5.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

You could be based in a university, combining chemical research with teaching; in a pharmaceutical company, working on developing and trialing new drugs; helping to ensure national healthcare provision keeps pace with new discoveries. , Product Details of 573-17-1, 573-17-1, Name is 9-Bromophenanthrene, molecular formula is C14H9Br, belongs to naphthyridine compound. In a document, author is Behlen, Michael J., introduce the new discover.

Dinickel naphthyridine-bis(oxazoline) catalysts promote enantioselective intermolecular [4 + 1]-cycloadditions of vinylidene equivalents and 1,3-dienes. The products of this reaction are methylenecyclopentenes, and the exocyclic alkene is generally obtained with high Z selectivity. E- and Z-dienes react in a stereoconvergent fashion, providing cycloadducts with the same sense of absolute stereochemistry and nearly identical ee values. This feature allows dienes that are commercially available as E/Z mixtures to be used as substrates for the cycloaddition. A DFT model for the origin of asymmetric induction is provided.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. Welcome to check out more blogs about 573-17-1, in my other articles. Product Details of 573-17-1.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, spectroscopic, and theoretical assessments of solvent structures and their interactions with reaction intermediates. 1588-83-6, Name is 4-Amino-3-nitrobenzoic acid, SMILES is C1=C([N+]([O-])=O)C(=CC=C1C(=O)O)N, belongs to naphthyridine compound. In a document, author is Asahrara, Haruyasu, introduce the new discover, Formula: https://www.ambeed.com/products/1588-83-6.html.

A practical, convenient, and safe cyano(nitro)methylation method was developed, in which cyano-aci-nitroacetate served as a synthetic equivalent of anionic nitroacetonitrile. A control of the single/double Michael additions was achieved, which enabled the synthesis of unsymmetrical double Michael adducts. Moreover, the Michael adducts can be used as precursors of pyridine and naphthyridine frameworks. (C) 2014 Elsevier Ltd. All rights reserved.

Future efforts will undeniably focus on the diversification of the new catalytic transformations. In my other articles, you can also check out more blogs about 1588-83-6. Formula: https://www.ambeed.com/products/1588-83-6.html.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Some examples of the diverse research done by chemistry experts include discovery of new medicines and vaccines, improving understanding of environmental issues, and development of new chemical products and materials. 179324-87-9, Name is (R)-BoroLeu-(+)-Pinanediol trifluoroacetate, molecular formula is C17H29BF3NO4, Related Products of 179324-87-9, belongs to naphthyridine compound, is a common compound. In a patnet, author is Manera, C, once mentioned the new application about 179324-87-9.

A series of 1,8-naphthyridine derivatives bearing various substituents in position 3, 4, and 7 of the heterocyclic nucleus have been synthesized and evaluated for their affinity at the bovine and human adenosine receptors. The new compounds were found to lack the affinity toward A(1)AR, whereas many of them are able to acquire an interesting affinity and selectivity for the A(2A)AR. (c) 2005 Elsevier Ltd. All rights reserved.

Related Products of 179324-87-9, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 179324-87-9.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem